DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Magi1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_006505643.1	Gene:	Magi1 / 14924	MGIID:	1203522	Length:	1484	Species:	Mus musculus

Alignment Length:	840	Identity:	168/840 - (20%)
Similarity:	265/840 - (31%)	Gaps:	270/840 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 GDLLKQIN--LNYERIEFQSP----QQPSISNLLRRAL---ERSSTRGVNLMGVASSKQSKQQWR 460
            |.|.|.:.  || :|.:..||    ||....||.|.|:   .||...| .:.||..|..:.:::.
Mouse   106 GRLNKDLRHFLN-QRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREG-EVPGVDYSFLTVKEFL 168

  Fly   461 KLD-SAEVVQVSRICGMYYAALNTLSQ------MKLDIL-----------------------TGI 495
            .|: |..:::|....|.||......||      :..|.|                       .||
Mouse   169 DLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGI 233

  Fly   496 CYSDN-----------------------VLYDIWL--LITSL------GPNCGMKEYLELLKSET 529
            .:.:|                       .|.:..|  :.:|:      .|:....:||. |.:|.
Mouse   234 VHPENEEEEDVPEMNSSFTADSGDQDEHTLQEATLPPVNSSILAAPITDPSQKFPQYLP-LSAED 297

  Fly   530 NL-QKPQTAML-------MLFCDCMTHYVTILDEHEMYTEQNPF--------------------- 565
            || ..|:...:       :.|.|..|...:.||...:..:|.|.
Mouse   298 NLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEEGVHTEELDSELEL 362

  Fly   566 -----KLNDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTP-P 624
                 |:.|.|...|::::|..|...:|.:..||...|            ...::..::|..| |
Mouse   363 PAGWEKIEDPVYGVYYVDHINRKTQYENPVLEAKRKKQ------------LEQQQQQQQPQPPQP 415

  Fly   625 KHW------LIPEVKPSTFINDLEKAKRNAMLLLAKMPHII--PHEDRVKLFRKFVQNEKAVMGL 681
            :.|      ::|.|.||...::.|.|:...   |...|...  |.|.:.|.....::......|.
Mouse   416 EEWTEDHASVVPPVAPSHPPSNPEPARETP---LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGF 477

  Fly   682 TESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVR--FINQQGLHEAGIDQDGVFKE 744
            |......|...|.:   ..:|.||        ..||.|.:...  .::.......|.....|.|.
Mouse   478 TVVGGDEPDEFLQI---KSLVLDG--------PAALDGKMETGDVIVSVNDTCVLGHTHAQVVKI 531

  Fly   745 FLEETIKKVFDPSLNLFKTTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVV------D 803
            |....|....|..|        .|.||.|.. ..|.:..|...|. :|.|   |.|:|      |
Mouse   532 FQSIPIGASVDLEL--------CRGYPLPFD-PDDPNTSLVTSVA-ILDK---EPIIVNGQETYD 583

  Fly   804 VPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKH-YKQDVSDLN---------LTFS 858
            .|.:.   |...|:..    |..|..||...::..:.:   | |..|...|.         :|..
Mouse   584 SPASH---SSKTGKVS----SMKDARPSSPADVASNSS---HGYPNDTVSLASSIATQPELITVH 638

  Fly   859 VDQDVMGKIVTLALHPGG------------KARVVNDHNKLVYI---HYMAFFHMNTQIREQTIA 908
            :.:..||...|:|..|||            :.|.:.:.:.:|.:   :..|..|  .|:.:..|.
Mouse   639 IVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTH--NQVVDMLIE 701

  Fly   909 FNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQ---KHT-------HYYGGFHDTHQVV 963
            ..:|....:..:...|..|.:     |..:.||:.||.|   :|:       |.....|....:.
Mouse   702 CPKGSEVTLLVQRGGLPVPKK-----SPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHGIQVLP 761

  Fly   964 CWL-WDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRG 1027
            .:| .|..|.|.|:          :|..|.|        .||.|.....|..|:.
Mouse   762 EYLPADAPAPDQTD----------SSGQKKP--------DPFKIWAQSRSMYENR---------- 798

  Fly  1028 FFAIRKKDPLNRLPTS------------STCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
                    |::..|.|            ||.|...::|:||::..      :.....|||
Mouse   799 --------PMSPSPASGLSKGERDREINSTNFGECQIPDYQEQDI------FLWRKETGF 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	88/438 (20%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	81/412 (20%)
Magi1	XP_006505643.1	PDZ_signaling	15..100	CDD:238492
		GuKc	122..293	CDD:214504	33/172 (19%)
		WW	302..331	CDD:366073	5/28 (18%)
		WW	362..393	CDD:197736	7/30 (23%)
		PDZ	462..548	CDD:214570	18/104 (17%)
		PDZ	633..716	CDD:214570	15/84 (18%)
		MAGI_u5	715..798	CDD:374709	24/105 (23%)
		PDZ_signaling	840..915	CDD:238492	3/5 (60%)
		PDZ_signaling	989..1084	CDD:238492
		PDZ	1145..1227	CDD:214570
		PRK12678	1203..>1452	CDD:237171
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900