DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	402	Identity:	68/402 - (16%)
Similarity:	128/402 - (31%)	Gaps:	136/402 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   618 RRPFTPPKHWLI--PEVKPSTFIN--------------DLEKAKRNAMLLLAKMPHIIP------ 660
            |||.||.:...:  |:.:.|..|:              :.....|.:|..:..|.|.:.
Human   585 RRPHTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHG 649

  Fly   661 ---------------HEDRVKLFRKFVQNEKAVMGLTESACASPRS-----------ALIVIHRD 699
                           |:.::...|.|..::.....||...|.:..:           .|.:.:.:
Human   650 KSLEELSLLLTRLRRHQAKLASVRNFAISQLLQHQLTFPTCQADDTYLQLKKDLEYLDLKIKNNE 714

  Fly   700 RIVEDGYRQL-----AAQPTQALKG--VIRVRFINQQGLHEAGID--------QDGVFKEFLEET 749
            .::...|:.|     ..:|.:::.|  :::.|.:....:.|:..|        ||.|.:: ||:.
Human   715 PLINVLYKVLKKSARGCRPRRSMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQD-LEDK 778

  Fly   750 IKKVFDPSLNLFKTTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQL 814
            |:.:        |...||.   ..:..|....:|.:....:.|.|..|:             .:|
Human   779 IRAL--------KENKDQL---ESVLEVLHRQMEQYRDQPQHLEKIAYQ-------------QKL 819

  Fly   815 LGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKAR 879
            |   |:.|.....||.....|:..:.......:.||..|..|..
Human   820 L---QEDLVHIRAELSRESTEMENAWNEYLKLENDVEQLKQTLQ--------------------- 860

  Fly   880 VVNDHNKLVYIHYMAFFHMNTQIREQT---------IAFNR-GFR----SIVNPE--WLSLFSPP 928
              ..|.:..      ||...:||::..         ::.|: .||    |:.|||  .:.||..|
Human   861 --EQHRRAF------FFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPERKTVPLFPHP 917

  Fly   929 ELQRLISGDTSP 940
            .:..|.:.::.|
Human   918 PVPSLSTSESKP 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	49/278 (18%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	46/249 (18%)
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827
		PH_PEPP1_2_3	159..281	CDD:270068
		NESP55	<299..460	CDD:115071
		DUF1640	779..905	CDD:311647	29/181 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900