DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and HECTD2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001271203.2	Gene:	HECTD2 / 143279	HGNCID:	26736	Length:	780	Species:	Homo sapiens

Alignment Length:	707	Identity:	163/707 - (23%)
Similarity:	266/707 - (37%)	Gaps:	168/707 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   447 MGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLLITS 511
            :..|..|.:...:..::.:. :....:..:|...|||...::..:|.||.   |.|...|
Human   165 LNAAFKKDATASFNTIEDSG-INAKFVNAVYDTLLNTPQDVQKTVLKGII---NSLLREW----- 220

  Fly   512 LGPNC--GMKEYLELLKSETNLQKPQ---TAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYV 571
            .||..  .::.|..|      ||.||   |:..:::...:....|:::.             |:.
Human   221 KGPRTKDDLRAYFIL------LQNPQFNNTSTYVIYAHLLRQIATLVEA-------------DHH 266

  Fly   572 LLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPK-------HWLI 629
            .|.::......:|.........:.::|   |:||...           |..|.:       .|.|
Human   267 FLVHWFKKQYSRLSQKRFKQLVERLLQ---FISLRLF-----------PAKPEEFPPITKCSWWI 317

  Fly   630 PEVKPSTFINDLEKAKRNAMLLLAK---MPHIIPHE-------DRVKLFRKF------------- 671
            |..           ||..|:|..|.   .|.:||:.       |.:.|..::
Human   318 PSA-----------AKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFS 371

  Fly   672 ----------------VQNEK-------AVMGLTESACASPRSALIV------IHRDRIVEDGYR 707
                            :|.:.       |...|.:......|..:.:      :.|..:|.|...
Human   372 FCQYPFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLD 436

  Fly   708 QLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPS 772
            :|..:... ||..::|.|:.     |||:|..|:.||:....|:::|.|...:|....|...:..
Human   437 ELTRKRAD-LKKKLKVTFVG-----EAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWF 495

  Fly   773 PISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLG----QTQQAL-----YSCMDE 828
            . |:..||:.| |..||.::|.|||..|.:|:.|......:||.    .:.|.:     ...:|:
Human   496 S-SFKCDNYSE-FRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDD 558

  Fly   829 LPSLDNELYRSLTFIKHYKQDV-SDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHY 892
            |..:..||...|:.:..::.:| .|...||.|.|:..|.|.:..|.|||....|.:.|:..|:..
Human   559 LCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQL 623

  Fly   893 MAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSP-LDLKDLQKHTHYYGGF 956
            ...|.:|..|.:|..||..||.|:.....|.|..|.|::.|:.|  || ||:..||:.|. |.|:
Human   624 YTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCG--SPDLDMHALQRSTQ-YDGY 685

  Fly   957 HDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTI 1021
            ..|...:.:.||::. .|..:.:|..|.|.|...:.|:.|.|.|.
Human   686 AKTDLTIKYFWDVVL-GFPLDLQKKLLHFTTGSDRVPVGGMADLN-------------------- 729

  Fly  1022 GSVIRGFFAIRKKD-PLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1077
                   |.|.|.: ..|.||.:.||||.|.||.|:.|..|:.||...:|::.||.|
Human   730 -------FKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	113/399 (28%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	107/368 (29%)
HECTD2	NP_001271203.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
HECTD2	NP_001271203.2	HECTc	421..778	CDD:238033	113/395 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810