DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Ube3b

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_473434.2	Gene:	Ube3b / 117146	MGIID:	1891295	Length:	1070	Species:	Mus musculus

Alignment Length:	1100	Identity:	523/1100 - (47%)
Similarity:	709/1100 - (64%)	Gaps:	52/1100 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MF--AQNQKASFLEQTKAAREERALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENH 63
            ||  :|..:|.|:::.:.|||||.::|.||::|:.:|:.::.:..||:..:.|..:.|..|:.
Mouse     1 MFTVSQTSRAWFIDRARQAREERLVQKERERSAVTIQALVRSFLCRRRLHRDIRKEIDEFFSA-- 63

  Fly    64 DDKDAELELVASNVYPVLRRYLTQIRLDKSDVRARERLERICRYIIKAMESEN-TKLSYAALCLF 127
             |:....:..|..::.:.||.|...:..:..    ||||::||.|:.:|::|| .|:.|.:|.|.
Mouse    64 -DESGSSKRSALCIFKIARRLLFICKTTEDS----ERLEKLCRSILNSMDAENEPKVWYVSLALS 123

  Fly   128 KERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQP 192
            |:.:|.||..||.:|.:|..||.:||||...||..:.|:|..||.||...:|.||| .:.|.|:|
Mouse   124 KDLTLLWIKQIKSILWHCCELLGQLKPEILQDSRLITLYLTMLVTFTDTSTWKILR-GKGESLRP 187

  Fly   193 AMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAK 257
            |:..||.||.|||.|...|.:::::|.||..|....:....|.|..:|.|||::...||.||:..
Mouse   188 ALNHICANIMGHLNQRGLYSVLQVLLTRGLARPRPCLSKGMLTAAFSLALRPVVAAQFSDNLMRP 252

  Fly   258 FLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEEFGTSMPGTKSLAFLGNIV 322
            |:..::|||||:.||....|:.|....|..:|:|.:....|.....:...|:.|..:|..:||::
Mouse   253 FIIHVMSVPALVAHLSTVAPERLGVLESHDMLRKFIVFLRDRDRCRDACESLEGCHTLCLMGNLL 317

  Fly   323 NLFNIDGQGESKELAYPLLTETTTSLLELIPN--------TVTTKGVFTQWHELLGWHTPGPEPA 379
            :|         ..|:..||.|.....:..:..        ....|...|.||.:|||.:...:..
Mouse   318 HL---------GSLSLRLLEEEMDGFVSALTQMLCYCQKYVAQKKSNLTHWHPVLGWFSQPVDYG 373

  Fly   380 QNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPS---------ISNLLRRA 435
            .|.::.||.||...||....|::|..|:|.:..|.:..   .:|.||.         :.:||:||
Mouse   374 LNDSMYLITKQLQFLWAVPLIRILFSDILSRKLLEHAE---PAPVQPQPSSPQTVLPVKSLLKRA 435

  Fly   436 LERS-STRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSD 499
            .::| |.|.: |..|..        |::|||||.:|..||.:|..:|.||:|::|.||||:.|.|
Mouse   436 FQKSASVRNI-LRPVGG--------RRVDSAEVRKVCNICVLYQTSLTTLTQIRLQILTGLTYLD 491

  Fly   500 NVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNP 564
            ::|..:|..|..|||:.|:|.:||.|.::|...|...|||||||||..|.:||||:.|:|.||..
Mouse   492 DLLPKLWAFICELGPHGGLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQIS 556

  Fly   565 FKLNDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLI 629
            |||.:.|.::.|||:.::|:|.|.::..||..... :|.|:|..::.||.|||||.|.|..|||.
Mouse   557 FKLEELVTISSFLNSFVFKMIWDGIVENAKGETLE-LFQSVHGWLMVLYERDCRRRFAPEDHWLR 620

  Fly   630 PEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALI 694
            .::||.....:|:|.:|.|.|:|..:||::||::||.|||..|..||..:||.|::.|||....|
Mouse   621 RDLKPGVLFQELDKDRRRAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHI 685

  Fly   695 VIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLN 759
            .|.|.|::||||.||......|:||||||:|:|..|:.||||||||||||||||.||:||||:||
Mouse   686 TIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALN 750

  Fly   760 LFKTTS-DQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALY 823
            |||||| |:||||||.||:.:|:|:||||||:|||||||||||||||||||||||:||......|
Mouse   751 LFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFY 815

  Fly   824 SCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLV 888
            |.:|||||||:|.|::||.||.|..|::||.||.|.|:||||::|...|.||||...|.|.||:.
Mouse   816 SSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKIS 880

  Fly   889 YIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYY 953
            |||.||.|.|:|||:.||.|...|||||:.|||:.:||.||||||||||.:.:||:||:|||.||
Mouse   881 YIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYY 945

  Fly   954 GGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTG 1018
            ||||.:|:|:.|||||||.|||.|||.:|||||||||:|||||||:|:|||||||||||||:|||
Mouse   946 GGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTG 1010

  Fly  1019 DTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
            ||:|||:||||.|||::|..|||||||||||||||||.|||.||:|||||:|.|||||||
Mouse  1011 DTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	267/382 (70%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	255/357 (71%)
Ube3b	NP_473434.2	HECTc	684..1068	CDD:238033	267/383 (70%)
Ube3b	NP_473434.2	HECTc	709..1067	CDD:214523	255/357 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840827
Domainoid	1	1.000	492	1.000	Domainoid score	I367
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13775
Inparanoid	1	1.050	981	1.000	Inparanoid score	I314
Isobase	1	0.950	-	0	Normalized mean entropy	S2001
OMA	1	1.010	-	-		QHG48068
OrthoDB	1	1.010	-	-		D1163565at2759
OrthoFinder	1	1.000	-	-		FOG0006345
OrthoInspector	1	1.000	-	-		oto92030
orthoMCL	1	0.900	-	-		OOG6_100865
Panther	1	1.100	-	-	LDO	PTHR45700
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1831
SonicParanoid	1	1.000	-	-		X4619
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750