Protein Alignment CG5087 and Ube3b

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_473434.2
• Gene: Ube3b / 117146
• MGIID: 1891295
• Length: 1070
• Species: Mus musculus
• Alignment Length: 1100
• Identity: 523/1100 - (47%)
• Similarity: 709/1100 - (64%)
• Gaps: 52/1100 - (4%)

  Fly     1 MF--AQNQKASFLEQTKAAREERALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENH 63
            ||  :|..:|.|:::.:.|||||.::|.||::|:.:|:.::.:..||:..:.|..:.|..|:.
Mouse     1 MFTVSQTSRAWFIDRARQAREERLVQKERERSAVTIQALVRSFLCRRRLHRDIRKEIDEFFSA-- 63

  Fly    64 DDKDAELELVASNVYPVLRRYLTQIRLDKSDVRARERLERICRYIIKAMESEN-TKLSYAALCLF 127
             |:....:..|..::.:.||.|...:..:..    ||||::||.|:.:|::|| .|:.|.:|.|.
Mouse    64 -DESGSSKRSALCIFKIARRLLFICKTTEDS----ERLEKLCRSILNSMDAENEPKVWYVSLALS 123

  Fly   128 KERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQP 192
            |:.:|.||..||.:|.:|..||.:||||...||..:.|:|..||.||...:|.||| .:.|.|:|
Mouse   124 KDLTLLWIKQIKSILWHCCELLGQLKPEILQDSRLITLYLTMLVTFTDTSTWKILR-GKGESLRP 187

  Fly   193 AMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAK 257
            |:..||.||.|||.|...|.:::::|.||..|....:....|.|..:|.|||::...||.||:..
Mouse   188 ALNHICANIMGHLNQRGLYSVLQVLLTRGLARPRPCLSKGMLTAAFSLALRPVVAAQFSDNLMRP 252

  Fly   258 FLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEEFGTSMPGTKSLAFLGNIV 322
            |:..::|||||:.||....|:.|....|..:|:|.:....|.....:...|:.|..:|..:||::
Mouse   253 FIIHVMSVPALVAHLSTVAPERLGVLESHDMLRKFIVFLRDRDRCRDACESLEGCHTLCLMGNLL 317

  Fly   323 NLFNIDGQGESKELAYPLLTETTTSLLELIPN--------TVTTKGVFTQWHELLGWHTPGPEPA 379
            :|         ..|:..||.|.....:..:..        ....|...|.||.:|||.:...:..
Mouse   318 HL---------GSLSLRLLEEEMDGFVSALTQMLCYCQKYVAQKKSNLTHWHPVLGWFSQPVDYG 373

  Fly   380 QNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPS---------ISNLLRRA 435
            .|.::.||.||...||....|::|..|:|.:..|.:..   .:|.||.         :.:||:||
Mouse   374 LNDSMYLITKQLQFLWAVPLIRILFSDILSRKLLEHAE---PAPVQPQPSSPQTVLPVKSLLKRA 435

  Fly   436 LERS-STRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSD 499
            .::| |.|.: |..|..        |::|||||.:|..||.:|..:|.||:|::|.||||:.|.|
Mouse   436 FQKSASVRNI-LRPVGG--------RRVDSAEVRKVCNICVLYQTSLTTLTQIRLQILTGLTYLD 491

  Fly   500 NVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNP 564
            ::|..:|..|..|||:.|:|.:||.|.::|...|...|||||||||..|.:||||:.|:|.||..
Mouse   492 DLLPKLWAFICELGPHGGLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQIS 556

  Fly   565 FKLNDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLI 629
            |||.:.|.::.|||:.::|:|.|.::..||..... :|.|:|..::.||.|||||.|.|..|||.
Mouse   557 FKLEELVTISSFLNSFVFKMIWDGIVENAKGETLE-LFQSVHGWLMVLYERDCRRRFAPEDHWLR 620

  Fly   630 PEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALI 694
            .::||.....:|:|.:|.|.|:|..:||::||::||.|||..|..||..:||.|::.|||....|
Mouse   621 RDLKPGVLFQELDKDRRRAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHI 685

  Fly   695 VIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLN 759
            .|.|.|::||||.||......|:||||||:|:|..|:.||||||||||||||||.||:||||:||
Mouse   686 TIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALN 750

  Fly   760 LFKTTS-DQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALY 823
            |||||| |:||||||.||:.:|:|:||||||:|||||||||||||||||||||||:||......|
Mouse   751 LFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFY 815

  Fly   824 SCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLV 888
            |.:|||||||:|.|::||.||.|..|::||.||.|.|:||||::|...|.||||...|.|.||:.
Mouse   816 SSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKIS 880

  Fly   889 YIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYY 953
            |||.||.|.|:|||:.||.|...|||||:.|||:.:||.||||||||||.:.:||:||:|||.||
Mouse   881 YIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYY 945

  Fly   954 GGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTG 1018
            ||||.:|:|:.|||||||.|||.|||.:|||||||||:|||||||:|:|||||||||||||:|||
Mouse   946 GGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTG 1010

  Fly  1019 DTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
            ||:|||:||||.|||::|..|||||||||||||||||.|||.||:|||||:|.|||||||
Mouse  1011 DTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745	9/29 (31%)
		HECTc	694..1076	CDD:238033	267/382 (70%)
Ube3b	NP_473434.2	HECTc	684..1068	CDD:238033	267/383 (70%)