DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Magi2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_446073.2	Gene:	Magi2 / 113970	RGDID:	621855	Length:	1277	Species:	Rattus norvegicus

Alignment Length:	838	Identity:	151/838 - (18%)
Similarity:	263/838 - (31%)	Gaps:	308/838 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 LPELKP-----ENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQPAMQKIC-------CNI 201
            |.|:||     |:.:..:|..|.|.   |...|.:...:|:..      |:.|.|       |..
  Rat    44 LGEVKPGKVAYESGSKLVSEELLLE---VNETPVAGLTIRDVL------AVIKHCKDPLRLKCVK 99

  Fly   202 QGHLVQHDFYKIMRLVLIRGTVREELS--VKPVTLVAIITLCLRPLIDGNFSRNLLAKFLSEILS 264
            ||.:|..|....:.|...:|:|..||.  ::....:..:....||..:|               .
  Rat   100 QGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEG---------------E 149

  Fly   265 VPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEE--FGTSMPGTKSLAFLGNIVNLFNI 327
            ||.:.| :..:|...:|...|..||:     ||.   :|:  :||..|..:....|.|:.:
  Rat   150 VPGVDY-IFITVEDFMELEKSGALLE-----SGT---YEDNYYGTPKPPAEPAPLLLNVTD---- 201

  Fly   328 DGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFH 392
                                  :::|..                 ||..|..:.:|.::
  Rat   202 ----------------------QILPGA-----------------TPSAEGKRKRNKSV------ 221

  Fly   393 MLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQ 457
                                .|.|:...:.|::           |......||..||..:.:|.:
  Rat   222 --------------------TNMEKASIEPPEE-----------EEEERPVVNGNGVVITPESSE 255

  Fly   458 QWRKLDSAEVVQVSR-ICGMYYAALNTLSQMKLDILTGICYSDN----VLYDIWLLITSLGPNCG 517
            ...|...|.....|: .....|:....|.. ::|........:|    .|.|.|.:
  Rat   256 HEDKSAGASGETPSQPYPAPVYSQPEELKD-QMDDTKSTKPEENEDSDPLPDNWEM--------- 310

  Fly   518 MKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILD---------EHEMYTEQNPF---KLNDY 570
              .|.|  |.|           :.|.|..|...:.||         ..|....:.|:   |::|.
  Rat   311 --AYTE--KGE-----------VYFIDHNTKTTSWLDPRLAKKAKPAEECKENELPYGWEKIDDP 360

  Fly   571 VLLTYFLNNILYKLINDN-LLAGAKNIVQH--------------------PVF------LSLHTL 608
            :..||::::|..:...:| :|...:.:.||                    |:|      |....|
  Rat   361 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFL 425

  Fly   609 MLCLYRRDCRRPFT------PPKHWLIPEVKPS---------------TFINDLEKAKRNAMLLL 652
            ...|.:.:....||      |.:...:..|.|.               .:||:           :
  Rat   426 STTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINE-----------V 479

  Fly   653 AKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQAL 717
            ..:.|  .|.|.||||      :...:|         :|..:|:.|      || .|...|....
  Rat   480 CVLGH--THADVVKLF------QSVPIG---------QSVNLVLCR------GY-PLPFDPEDPA 520

  Fly   718 KGVIRVRFINQQ-------GLHEAGIDQDGVFKEFLEETIKKVFD----PSLNLFKTTSDQRL-- 769
            ..::....|.::       |.|..     ..:.|::..|.:.|.|    |..:|....:|.:|
  Rat   521 NSMVPPLAIMERPPPVMVNGRHNY-----ETYLEYISRTSQSVPDITDRPPHSLHSMPADGQLDG 580

  Fly   770 -YPSPISYVQDNHLELFE---FVGRMLGKAVYEG------IVVDVPFASFFLSQLLGQTQQALYS 824
             ||.|   |.|:::.:..   ....::...:.:|      .:.|.|            |.|.:..
  Rat   581 TYPPP---VHDDNVSVASSGATQAELMTLTIVKGAQGFGFTIADSP------------TGQRVKQ 630

  Fly   825 CMD--ELPSL-DNELYRSLTFIKHYKQDVSDLNLTFSVD--QDV-MGKIVTLALHPGG 876
            .:|  ..|.| :.:|     .::..:|:|.:|:.|..||  :|. :|...:|.:|.||
  Rat   631 ILDIQGCPGLCEGDL-----IVEINQQNVQNLSHTEVVDILKDCPVGSETSLIIHRGG 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	43/212 (20%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	37/188 (20%)
Magi2	NP_446073.2	PDZ_signaling	22..96	CDD:238492	14/60 (23%)
		GuKc	118..291	CDD:214504	43/277 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..308		23/157 (15%)
		Interaction with DDN. /evidence=ECO:0000250	302..381		20/102 (20%)
		WW	304..333	CDD:395320	11/52 (21%)
		WW	350..381	CDD:197736	7/30 (23%)
		PDZ	428..509	CDD:214570	19/114 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..575		4/18 (22%)
		PDZ	602..683	CDD:214570	19/97 (20%)
		MAGI_u5	687..758	CDD:406953
		PDZ	775..861	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..913
		PDZ_signaling	920..1007	CDD:238492
		PRK10263	<1007..>1135	CDD:236669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1130
		PDZ_signaling	1140..1220	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900