DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5087 and Ube3c

DIOPT Version :9

Sequence 1:NP_648279.1 Gene:CG5087 / 39035 FlyBaseID:FBgn0035953 Length:1078 Species:Drosophila melanogaster
Sequence 2:NP_598668.1 Gene:Ube3c / 100763 MGIID:2140998 Length:1083 Species:Mus musculus


Alignment Length:1213 Identity:322/1213 - (26%)
Similarity:536/1213 - (44%) Gaps:289/1213 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 QNQKASFLEQTKAAREERALEKRREQAAILLQSTLKGYAARRK--YQKRIILDFDAMFTENHDDK 66
            :.:|||.|.:|:..|.:|..|:||.:.|:::||.::||..|::  :.:|...|   ..|::....
Mouse    22 KEEKASLLHRTQEERRKREEERRRLKNAVIIQSFIRGYRDRKQQYFIQRSAFD---QCTDSAQPG 83

  Fly    67 DAELELVASNVYPVLRRYLTQIRLDKSDVRARERLERICRY---IIKAMESENTKLSYAALCLFK 128
            .........|:..::|:.|...:..:...|.....:.:.::   .:|.::.     |....|||:
Mouse    84 GTFCLADGPNLTLLVRQLLFFYKQSEDSKRLIWLYQNLIKHSSLFVKQLDG-----SERLTCLFQ 143

  Fly   129 ERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSW-AILRNAQFEKLQP 192
                     ||.|::.|..||.....    |||::||.:..|.|||:..:: .:|:::.:     
Mouse   144 ---------IKRLMSLCCRLLQNCSD----DSLNVALPMRMLEVFTSENTYLPVLQDSSY----- 190

  Fly   193 AMQKICCNIQGHLVQHDFYKIMRLVL---IRGTVR-EELSVKPVTLVAIITLCLRPLIDGNFS-- 251
             :..:...|..::|...:|:.:.|::   :..::. .:||..|:..: ::...|:||   :|:  
Mouse   191 -VVSVIEQILHYMVHSGYYRSLYLLINSKLPSSIEYSDLSRVPIAKI-LLENVLKPL---HFTYS 250

  Fly   252 -------RNLLAKFLSEILSVPAL--IYHL--------QQSVPQCLEQFSSMGLLKKALS---IS 296
                   ..:.:.|..|.|..|..  |:|.        |...|  .|.|.:..||.::.|   .|
Mouse   251 SCPEASRHQVFSAFTEEFLGAPFTDQIFHFVIPAFADAQTVFP--YEPFLNALLLLESQSSKRCS 313

  Fly   297 GDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLLELIPNTVTTKGV 361
            | |.|...|        .|....|.:...:.||.     |.|..:.:|   .|..:|.:.|..|.
Mouse   314 G-VPWLFYF--------VLTVGENYLGALSEDGL-----LVYLRVLQT---FLSQLPASPTGTGC 361

  Fly   362 FTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQP 426
                          |:...:..                            :.|.|..:..||:..
Mouse   362 --------------PDSTSDSE----------------------------DDNEETDQPNSPEDG 384

  Fly   427 SIS------NLLRRALERSSTRG-VNLMGVASSKQSKQQWRKLDSAEV-VQVSRICGMYYAALNT 483
            .:|      ..||:...:..|.. :||:           ||...|.|| .:::.||       :|
Mouse   385 RVSAPYITEECLRKLDTKQQTNTLLNLV-----------WRDSASEEVFTRMASIC-------HT 431

  Fly   484 LSQM------KLDILTGICYSDNVLYDIWLLITSLGPNC---GMKEYLELLKSETNLQKPQTAML 539
            |...      |:.:|..:.::...|..:|.||:|:....   .|...|:|:...:.:....::.:
Mouse   432 LMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMTTQMITGSMVPLLQLISRGSPMSFEDSSRI 496

  Fly   540 M----LFCDCMTHYVTILDEHEMY-----------TEQNPFKLNDYVLLTYFLNNI---LYKL-- 584
            :    ||....:|.:..:.::|.:           :...||.|.:.:||:..|.:.   :.||  
Mouse   497 IPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELILLSRCLRDACLGIIKLAY 561

  Fly   585 ------INDNLLAGAKNI-------------------VQHPVFLSLHTLMLCLYRRDCRRPFTPP 624
                  :.:..:...::|                   ||  :|..:..|:..|..||.||.|.||
Mouse   562 PETKPEVREEYVTAFQSIGVTTNSEMQQCIQMEQKRWVQ--LFKVITNLVKMLKSRDTRRNFCPP 624

  Fly   625 KHWL---------------IP------------EVKP--STFINDLEK-----AKRNAMLLLAKM 655
            .|||               :|            .:.|  ||....||.     ::...:.:|.::
Mouse   625 NHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLEVGLESLPLSVSEERQLAILTEL 689

  Fly   656 PHIIPHEDRVKLFRKFVQNEKAVM--------GLTESACASPRSALIVIHRDRIVEDGYRQLAAQ 712
            |.::|.|:|||:|::.:..:|..:        |:.           :.|.|:.|.||.|.:|:.:
Mouse   690 PFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGIN-----------VTIRRNYIYEDAYDKLSPE 743

  Fly   713 PTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPIS-- 775
            ....||..|||..:|..||.|||||..|:|:|||.|.:|..|:|:...||||::..|||:|.:  
Mouse   744 NEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQM 808

  Fly   776 YVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSL 840
            .|.|:....:.|:|||||||:||.::|::|||.||||:|||.:...   .:..|.|||.|:||:|
Mouse   809 LVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADV---DIHHLASLDPEVYRNL 870

  Fly   841 TFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQ 905
            .|:|.|::||.:|.|.|:|..:.:|:...:.|..|||...|...|::.|||.:|.:.:|.|||..
Mouse   871 LFLKSYEEDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNKQIRPH 935

  Fly   906 TIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDIL 970
            .:||.:|..::|:.|||.:|...|:|.||||...|:.|:||:..|:|.||:...|.|:...|.::
Mouse   936 CLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFTNYSGGYSADHPVIKIFWRVV 1000

  Fly   971 AKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKD 1035
             :.||:||::..||||||||:||||||..|.|.|   |:.....:                    
Mouse  1001 -EGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAF---CIHNGGSD-------------------- 1041

  Fly  1036 PLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
             |.||||:|||.||||||.:..::.||.||.||:....|||||
Mouse  1042 -LERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFELS 1083

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5087NP_648279.1 HECTc 694..1076 CDD:238033 160/383 (42%)
HECTc 718..1075 CDD:214523 151/358 (42%)
Ube3cNP_598668.1 Cis-determinant of acceptor ubiquitin-binding. /evidence=ECO:0000250 1..60 14/37 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 6/17 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..386 7/73 (10%)
HECTc 723..1081 CDD:238033 160/396 (40%)
HECTc 747..1080 CDD:214523 152/360 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1163565at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100865
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1831
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.750

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