DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and HUWE1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_016884680.1	Gene:	HUWE1 / 10075	HGNCID:	30892	Length:	4501	Species:	Homo sapiens

Alignment Length:	989	Identity:	236/989 - (23%)
Similarity:	376/989 - (38%)	Gaps:	259/989 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 LIRGTVREELSVKPVTLV-----AIITLCLRPLIDGNFSR-------------NLLAKFLSE--- 261
            |:..|....:.|...|.|     |..|:.:.|...|:.|.             .:::..|:|
Human  3644 LVAATAISTIVVAASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQL 3708

  Fly   262 ILSVPALIYHLQQSVPQCLEQFSSMGLLKKA---LSIS-GDVQWFEEFGTSMPGTKSLAFLGNIV 322
            .|||..|..|      .|.|:    ||...|   |.:| ||           .||:.     .::
Human  3709 QLSVEVLTSH------SCSEE----GLEDAANVLLQLSRGD-----------SGTRD-----TVL 3747

  Fly   323 NLFNIDGQGESKELAYPLLTETTTSLLEL------------------------IPNTVTTKGVFT 363
            .|. ::|   ::.|.|.|..:..|.|.||                        .|.|...||...
Human  3748 KLL-LNG---ARHLGYTLCKQIGTLLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQ 3808

  Fly   364 QWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSP----- 423
            ...::.            :||.::..|          |..||..           |.|.|
Human  3809 SRFDMA------------ENVVIVASQ----------KRPLGGR-----------ELQLPSMSML 3840

  Fly   424 -QQPSISNLLRRALE-----RSSTRGVNL------------MGVASSKQSKQQWRKLDSAEVVQV 470
             .:.|......|.|:     |..||..|.            :|.|||.|:..:..:.::..::|:
Human  3841 TSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQM 3905

  Fly   471 ----SRICGMYYAALNTLSQMKLDILTGICYSDNVLYDI---------WLLITSLGPNCGMKE-- 520
                .|......||.:..||.:..:     ..:....|:         ...|.|.|...|.||
Human  3906 VREGQRARRQQQAATSESSQSEASV-----RREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKE 3965

  Fly   521 ----YLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNIL 581
                .|.||..:.:|.:    :..:..:|:.......|:|.:...|...:       .:||.:..
Human  3966 ERPPELPLLSEQLSLDE----LWDMLGECLKELEESHDQHAVLVLQPAVE-------AFFLVHAT 4019

  Fly   582 YK----LINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTP----------PKHWLIPEV 632
            .:    .:.|...:...:|...|..||...|          .|.||          |....|...
Human  4020 ERESKPPVRDTRESQLAHIKDEPPPLSPAPL----------TPATPSSLDPFFSREPSSMHISSS 4074

  Fly   633 KP----------STFINDLEKAKRNAMLLLAKMP--------HIIPHEDRVKLFRKFVQNEKAVM 679
            .|          .|....|.:..|.:...||..|        .::..:.:.|.||:  :.|:...
Human  4075 LPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQ--ELERLDE 4137

  Fly   680 GLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKE 744
            ||.:...|      :.:.||.:.||.||:|..:..:.:|..:.:.|   :|  |.|.|..|:.:|
Human  4138 GLRKEDMA------VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVF---EG--EEGQDAGGLLRE 4191

  Fly   745 FLEETIKKVFDPSLNLFKTTSDQRL-YP-SPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFA 807
            :.....:::|:|...||:|:...|: |. :|.|:...|||..|:||||::.||||:..:::..|.
Human  4192 WYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFT 4256

  Fly   808 SFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDL--NLTFSVDQDVMGKIVTL 870
            ..|...:||::.:  |:.|:   |.|...|:.|.::  .:.|||.|  :||||.:....|.....
Human  4257 RSFYKHILGKSVR--YTDME---SEDYHFYQGLVYL--LENDVSTLGYDLTFSTEVQEFGVCEVR 4314

  Fly   871 ALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLIS 935
            .|.|.|...:|.:.||..|:|.:....|...||:|..||..||..|:....:|:|:..||:.|||
Human  4315 DLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLIS 4379

  Fly   936 GDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHL 1000
            | ...:|:.||:.:|.|:....::.|:. |.|..| :.|.:.:|..||:|||..||.||.|||.|
Human  4380 G-LPTIDIDDLKSNTEYHKYQSNSIQIQ-WFWRAL-RSFDQADRAKFLQFVTGTSKVPLQGFAAL 4441

  Fly  1001 EPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKL 1065
            |....|:..::..|:.:.|                   |||::.||||.|.||.|:....||..|
Human  4442 EGMNGIQKFQIHRDDRSTD-------------------RLPSAHTCFNQLDLPAYESFEKLRHML 4487

  Fly  1066 RYAVSS-NTGFELS 1078
            ..|:.. :.||.|:
Human  4488 LLAIQECSEGFGLA 4501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	124/386 (32%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	116/361 (32%)
HUWE1	XP_016884680.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810