Protein Alignment CG5087 and smurf1

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: XP_002931540.1
• Gene: smurf1 / 100491582
• XenbaseID: XB-GENE-479046
• Length: 731
• Species: Xenopus tropicalis
• Alignment Length: 836
• Identity: 193/836 - (23%)
• Similarity: 317/836 - (37%)
• Gaps: 236/836 - (28%)

  Fly   327 IDGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQF 391
            :||.|:...      |:|       :.||:                    :|..||:..|...:.
 Frog    42 VDGSGQCHS------TDT-------VKNTL--------------------DPKWNQHYDLYVGKM 73

  Fly   392 H----MLWDHR------------CIKLLLGDLLKQINLNYERIEFQSPQQPSISNLLRRALERS- 439
            .    .:|:|:            |::||...:.:..:..|:|::. ....|:.|:.:|..:..|
 Frog    74 DSITISIWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDL-CKLNPADSDAVRGQIVVSL 137

  Fly   440 STRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYD 504
            .||  :.:|...|              ||.    |                  .|:..:|..||:
 Frog   138 QTR--DRIGTVGS--------------VVD----C------------------RGLLDNDGALYE 164

  Fly   505 IWLLITSLGP----NCGMKE---YLE-----------LLKSETNLQKPQTAMLMLFCDCMTHYVT 551
                  ..||    :|.|.|   |.:           |::|....|:.| |..:...:...|..|
 Frog   165 ------DAGPGRPLSCFMDEPAPYTDGPGAAGGGPCRLVESPGQEQRLQ-AQRLRGPEVREHVQT 222

  Fly   552 ILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLAG--AKNIVQHPVFLSLHTLMLCLYR 614
            .|:....|..|                         :|..|  .:..||..|:. |||.......
 Frog   223 PLNRSHGYQSQ-------------------------DLPEGYEQRTTVQGQVYF-LHTQTGVSTW 261

  Fly   615 RDCRRP----------FTP-PKHWLIPEVKP--STFINDLEKAKRNAMLLLAKMPHIIPHEDRVK 666
            .|.|.|          ..| |..|   ||:.  |..|..::...|.......::.|||.|:.::|
 Frog   262 HDPRIPRDLNSVNCDDLGPLPTGW---EVRTTVSGRIYFVDHNNRTTQFTDPRLHHIINHQSQLK 323

  Fly   667 ------------------------LFRKFVQNEKAVMGLTESACASPRS--ALIVIHRDRIVEDG 705
                                    ..|..||..|.:.  .|.:...|::  ..:.:.|:.|.|:.
 Frog   324 EPNNAIPVQSDGSLEEGDEFPTQRYERDLVQKLKVLR--HELSLLQPQAGHCRVEVSREEIFEES 386

  Fly   706 YRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQ--R 768
            |||:.....:.||..:.|:|..::||     |..||.:|:|.....::.:|...||:.::|.  .
 Frog   387 YRQIMKMRPKDLKKRLMVKFRGEEGL-----DYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYT 446

  Fly   769 LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLD 833
            |..:|.|.:..:||..|.||||::|.||:.|..::..|...|..||||:..|     :.:|.|:|
 Frog   447 LQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQ-----LSDLESVD 506

  Fly   834 NELYRSLTFIKHYKQDV-SDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFH 897
            .||::||.:|  .:.|: |.|:.||.|:.:..|:::...|.|.||...|.:.||..|:.....:.
 Frog   507 PELHKSLVWI--LENDITSVLDHTFCVEHNAFGRLLQHELKPNGKNLQVTEENKKEYVRLYVNWR 569

  Fly   898 MNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQV 962
            ....|..|.:|..:||..::....|..|...||: ||.|....:|:.|.:.:|.......::: :
 Frog   570 FMRGIEAQFLALQKGFNELIPQHLLKPFEQKELE-LIIGGLDKIDISDWKANTRLKHCLANSN-I 632

  Fly   963 VCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPP--------FSIRCVEVSDDEDTGD 1019
            |.|.|..: :.|.||.|...|:|||..::.||.||..|:..        |:|..::.:.|
 Frog   633 VQWFWQAV-ESFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTD----- 691

  Fly  1020 TIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
                               .||.:.||||.:.:|.|:....|.:||..||...:||
 Frog   692 -------------------NLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETSGF 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	114/393 (29%)
smurf1	XP_002931540.1	C2_Smurf-like	14..138	CDD:176028	22/129 (17%)
		WW	234..266	CDD:197736	9/32 (28%)
		WW	280..312	CDD:197736	8/34 (24%)
		HECTc	373..728	CDD:238033	112/393 (28%)