DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and herc3

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_002938676.3	Gene:	herc3 / 100488790	XenbaseID:	XB-GENE-968537	Length:	1050	Species:	Xenopus tropicalis

Alignment Length:	967	Identity:	221/967 - (22%)
Similarity:	364/967 - (37%)	Gaps:	237/967 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 FLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDV-QWFEEFGTSMPGTKSL------ 315
            |||:  |.|..:..| :.:|  |.|.::.|....|||:||.| .|    |.:..|...|
Frog   175 FLSQ--SSPQRVKSL-EGIP--LAQVTAGGSHSFALSLSGAVFGW----GNNSAGQLGLNDEKVR 230

  Fly   316 ------------------------AFLGNIVNLFNIDGQGESKELAYPLLTE--TTTSLLELIPN 354
                                    |.|.....||.. |.|.|.:|.:..|..  ....:|||:.:
Frog   231 ETPCHVKPLRTHKVIYISCGEEHTAILTKAGGLFTF-GAGGSGQLGHDSLNNEINPRRVLELMGS 294

  Fly   355 TVTTKGVFTQWHELLGWHTPGPEPA------------------QNQNV---ALIK-------KQF 391
            .|:......|       ||....|:                  ...||   |::|       .|.
Frog   295 EVSQIACGRQ-------HTLAFVPSSGTLYAFGCGDLGQLGTGHKNNVKCPAVVKGKWAAHSGQI 352

  Fly   392 HMLWDHRCIKLLLGDLLKQI----NLNY---ERIEFQSP----------------QQPSISNLLR 433
            .|..|....     :::|||    |..:   .::|...|                .:.:|....:
Frog   353 SMHADRAAY-----NIVKQIFSGGNKTFVLCSKLESSQPADDFRFCSQRNHTSVINEETIDVWRQ 412

  Fly   434 RALERSSTRGVNLMGVASSKQSKQQW-----RKLDSAEVVQVSRICGMYYAALNTL--------- 484
            :.||.|:|..:|  |:..:..|...|     .|.:........:|.|:...::..|
Frog   413 KVLENSNTNSMN--GIVQTLSSLACWNGSFLEKRNDEHFRTSPKIPGINMCSIKVLFEKLMNVHH 475

  Fly   485 SQMKLDILTGICYSDNVLYDIWLL--ITSLGPNC-GMKEYLELLKSETNLQKPQTAMLMLFCDCM 546
            |::...||.|        ::.:|:  ::|..|:. .|:.|:.|         |:..:|    ...
Frog   476 SRLLEQILKG--------FESFLIPQLSSSPPDVEAMRIYIIL---------PEFPLL----QDS 519

  Fly   547 THYVTI---LDEHEMYTEQNPFKLND----YVLLTYFLNNI-LYKLINDNLLAGAKNIVQHPVFL 603
            .:|:|:   |....:..:.||.|:.|    .|...|||..| |||.....||.|.|.::...:|.
Frog   520 KYYITLTLPLAMAILRLDTNPSKVLDNWWAQVCPKYFLKLISLYKEAVVYLLNGRKTLLIPVLFT 584

  Fly   604 SLHT----LMLCLYRRDCRRPFTPPKHWLIPEVKPST---------FIND----LEKAKRNAMLL 651
            |..|    |:..|::.:.:........:.|||:....         |:|:    |........:.
Frog   585 SYITAALKLLEKLHKVNGKAQHVEHDTFYIPEISSLVDIQEDYLMWFLNEAGLKLRPTIMQDSIT 649

  Fly   652 LAKMPHIIPHEDRVKLFR-------------KFVQNEKAVMGLTESACASPRSALIVIH--RDRI 701
            |...|.:...:.:.|:.:             ..:||...::.|......:|   .:|:|  |..:
Frog   650 LCSYPFVFDAQAKTKMLQTDAELQMQVAINGANLQNVFMLLTLDPMLVKNP---FLVLHVRRTSL 711

  Fly   702 VEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSD 766
            |.|..|:|:......||..::|.|..     |..:|..||.|||....:|::.:|...:|....|
Frog   712 VADALRELSIYSDIDLKKPLKVIFDG-----EEAVDDGGVTKEFFLLLLKELLNPIYGMFTVYQD 771

  Fly   767 QR-LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELP 830
            .. |:.|.|.:|:.|   .|..:|.|.|.|:|...|||:.|......:||.     :...:::|.
Frog   772 SNLLWFSDICFVEHN---WFHLIGIMCGLAIYNFTVVDLYFPLALYKKLLN-----VQPTLEDLK 828

  Fly   831 SLDNELYRSLTFIKHY-KQDVSDL-NLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYM 893
            .|.....|||..:..| :.||.|: .|.|::.::..|......|..||....|...|:..::...
Frog   829 ELSPTEGRSLQELLDYPEDDVDDVFCLNFTICRESYGLAERRPLVAGGDHITVTKDNRQQFVDAY 893

  Fly   894 AFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHD 958
            ..:..|..::|...||:.||..:...:.|.||.|.||:.::.|..: .:.::|:::..|.|.:..
Frog   894 VNYVFNQSVQEWYEAFSTGFLKVCGGKILELFQPSELRSMVVGSNN-YNWQELEENAIYKGDYST 957

  Fly   959 THQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCV--EVSDDEDTGDTI 1021
            .|..|...|:.. .||..|::|.||.|:|...:.|:.|.:      |:|.:  .:|..||
Frog   958 AHPTVRMFWETF-HDFPLEKKKKFLLFLTGSDRIPIYGMS------SLRIIIQSISSGED----- 1010

  Fly  1022 GSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
                             .||.:.||:|||.||.|..|.|||.:|..|:....||.|:
Frog  1011 -----------------HLPVAHTCYNLLDLPKYSSKETLRRRLTQAIDHYEGFSLA 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	107/388 (28%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	98/361 (27%)
herc3	XP_002938676.3	RCC1	3..49	CDD:395335
		ATS1	44..353	CDD:227511	42/194 (22%)
		HECTc	702..1048	CDD:238033	107/388 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910