DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and trip12

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001136384.1	Gene:	trip12 / 100158539	XenbaseID:	XB-GENE-6071044	Length:	2056	Species:	Xenopus tropicalis

Alignment Length:	1122	Identity:	235/1122 - (20%)
Similarity:	383/1122 - (34%)	Gaps:	341/1122 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VASNVYPVLRRYLTQIRLDKSDVRARERLERICRYIIKAMESENTKLSYAALCLFKERSLP---- 133
            :....:..:.||.:...:|.|: .|...|:|:|    .|.|..|.::.....||.:.||:.
Frog  1160 IKEQAHKFVERYFSSENMDGSN-PALNVLQRLC----NATEQLNLQVDGGVECLVEIRSIVSESD 1219

  Fly   134 ----WIAH---IKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQ 191
                .|.|   :|.||   |.|..:...:..:..:.|..|||  |.|..|    :.......||.
Frog  1220 VSSFEIQHSGFVKQLL---LYLTSKSDKDIVSRDIRLKRFLH--VFFGTP----LPGEEPLAKLD 1275

  Fly   192 PAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLA 256
            |...:       ||        :.||........::...||.:...      |..:|..||...|
Frog  1276 PTENR-------HL--------LALVHKMNNCLSQMEQFPVKVHDF------PSGNGTGSRGSQA 1319

  Fly   257 -KFLSEILSVPALIYHLQQSVPQC------------LEQFSSMGLLKKALSISG------DVQWF 302
             ||    .:...|...||:. |.|            ::..:.:..:::.|.:.|      |.:..
Frog  1320 LKF----FNTHQLKCQLQRH-PDCTNVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDS 1379

  Fly   303 EEFGTSMPGTKSLA---------------FLGNIVNLFNIDGQGESKELAYPLLTETTTSLLELI 352
            ::.|:.....:|||               ::|:.:..:|:......::  |.:.||......:..
Frog  1380 DDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGDHLLPYNMTVYQAVRQ--YSIQTEEERESTDDE 1442

  Fly   353 PNTVTTKGVFTQWHELLGWHTP---------------------GPEPAQNQNVALIKKQFHMLW- 395
            .|.:...|::|:.|.:  |:.|                     .|.....:|    .|:...||
Frog  1443 SNPLGRAGIWTKTHTI--WYKPVREEEESAKDTVGGKRGRAQTAPTKTSPRN----SKKHDELWH 1501

  Fly   396 --DHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQ 458
              |..|.::|....:..|:...|.|.|..|....:  :|.|.|...|                :.
Frog  1502 GKDGVCPRILNPLEVYLISGPPENITFDDPSLDVV--ILLRVLHAIS----------------RY 1548

  Fly   459 WRKL-DSA---EVVQVSRICGMYYAA-LNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGM 518
            |..| |:|   |::..|........| .|...|..|.|:||     |:  ..||  |.||.:|
Frog  1549 WYYLYDNAVCKEIIPTSEFNNSKLTAKANRQLQDPLVIMTG-----NI--PTWL--TELGKSC-- 1602

  Fly   519 KEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYK 583
                       ....|.....|||      |||..|.                      :..:.:
Frog  1603 -----------PFFFPFDTRQMLF------YVTAFDR----------------------DRAMQR 1628

  Fly   584 LINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNA 648
            |::.|                                         ||:..|. ..|...|.|
Frog  1629 LLDTN-----------------------------------------PEINQSD-SQDSRVAPR-- 1649

  Fly   649 MLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDG-------Y 706
               |.:....:..||.:|      |.|..:..|..|      .|::.|..:..|..|       |
Frog  1650 ---LDRKKRTVNREDLLK------QAESVMQDLGSS------RAMLEIQYENEVGTGLGPTLEFY 1699

  Fly   707 RQLAAQPTQALKGVIR---VRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQR 768
            ..::.:..:|..|:.|   |...|.:|      .|:|.          |.......||.....:.
Frog  1700 ALVSQELQRADLGLWRGEEVTLPNPKG------SQEGT----------KYIHNLQGLFALPFGRT 1748

  Fly   769 LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQ-TQQALYSCMDELPSL 832
            ..|:.|:.|:..    |.|:|:::.||:.:..:||:|....|...:|.| :..|.:..::..|.:
Frog  1749 AKPAHIAKVKMK----FRFLGKLMAKAIMDFRLVDIPLGLPFYKWMLRQESSLATHDLVNIDPVV 1809

  Fly   833 DNELYRSLTFI---KHYKQD---------------------VSDLNLTFSVDQDVMGKIVTLALH 873
            ...:|.....:   |..:||                     |.||.|.|:     :.....:.|.
Frog  1810 AKSVYHLEDIVRQKKRLEQDKAQTKESLQFALESLNMNGCSVEDLGLDFT-----LPGFPNIELK 1869

  Fly   874 PGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGD- 937
            .|||...|..||...|:..:.::.:|..:..|..:|..||.|:.....|..|.|.||.:|:.|.
Frog  1870 KGGKDVPVTIHNLEDYVRLVIYWALNEGVSRQLDSFRDGFESVFPLNHLQYFYPEELDQLLCGSR 1934

  Fly   938 TSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEP 1002
            ..|.|:|.|.:......|:....:.|.:|::||: .|.:|:::|||:|||...:.|:.||..|.|
Frog  1935 ADPWDVKTLMECCRPDHGYTHDSRAVKFLFEILS-SFDKEQQRLFLQFVTGSPRLPVGGFRSLNP 1998

  Fly  1003 PFSIRCVEVSDDEDTGDTIGSVIRGFFAIRK-----KDPLNRLPTSSTCFNLLKLPNYQKKSTLR 1062
            |.:|                        :||     ::|.:.||:..||.|.||||:|.....:|
Frog  1999 PLTI------------------------VRKTFEATENPDDFLPSVMTCVNYLKLPDYSSIDNMR 2039

  Fly  1063 DKLRYAV-SSNTGFELS 1078
            :||..|. .....|.||
Frog  2040 EKLLMAAREGQQSFHLS 2056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	102/423 (24%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	97/391 (25%)
trip12	NP_001136384.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..440
		PHA03307	84..>462	CDD:223039
		SRP1	483..>708	CDD:227396
		WWE	805..866	CDD:397111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1147
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1465..1500		3/38 (8%)
		K-box. /evidence=ECO:0000250	1560..1634		26/164 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1632..1651		7/65 (11%)
		HECTc	1654..2054	CDD:238033	110/461 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910