DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and herc5.4

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_005160166.1	Gene:	herc5.4 / 100148091	ZFINID:	ZDB-GENE-090311-7	Length:	995	Species:	Danio rerio

Alignment Length:	842	Identity:	191/842 - (22%)
Similarity:	309/842 - (36%)	Gaps:	212/842 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 FEE-------FGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLL--TETTTSLLELIPNTVT 357
            |||       ||..|.|.     |||        |:...:.:..|:|  ||.|...:|
Zfish   287 FEESSKLIYSFGCGMQGQ-----LGN--------GEQVKQSVPLPVLLPTECTEFTME------- 331

  Fly   358 TKGVFTQWHEL-LGWHTPGPE---PAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERI 418
             |.:..:.|.. |.:..||.|   |....|..::.....|:                     :|.
Zfish   332 -KLITGEHHSFALFFKNPGNESEKPKSGSNGGILTLNDRMI---------------------DRW 374

  Fly   419 EFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNT 483
            ..:|...|::.|.:....  ||...:|...:.:|:....|    .|.|      .||:.:..:.|
Zfish   375 VSESDPWPTVKNEINTVF--SSAASLNGSFLKTSRDEHYQ----TSVE------HCGLDFDLVKT 427

  Fly   484 LSQMKLDILTGICYSDNVLYDIWLLITSLGPNC----GMKEYLELLKSETNLQKPQTAMLMLFCD 544
             |..|| ..:....|:.|......|:.||.||.    .::.||.|.:....|:|.:|.::    :
Zfish   428 -SFAKL-FASKSLISEVVKVVQQTLLPSLNPNPTGVEALRLYLLLPELINGLKKQRTKLI----E 486

  Fly   545 CMTHYVTILDEH-----EMYTEQNP----------FKLNDYVLL-----------TYFLNNILYK 583
            .:...:..|:..     |||..:.|          |......|:           |..|.|||..
Zfish   487 ALASKILELNSAARKVLEMYWSRLPDDWFERLIKLFHKESTDLIDQICDETDHQSTRHLKNILEI 551

  Fly   584 LINDNLLAGAKNIVQHPVFLS--------LHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFIND 640
            |.....::.:.:|..|...:.        |.|:...|.|.:.........|.::          .
Zfish   552 LQMAYQISCSTDITHHDFIIHKINDLLDLLQTITADLLRMELYMQINEDFHDMV----------K 606

  Fly   641 LEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDG 705
            ||:.....:.:|.|.|.......:.::|.  :..|:....:...|..:..|.|:.|:|:.::.|.
Zfish   607 LEEYYFRTVKILVKFPFASDFITKQRMFN--LLQEECFRNVPNLAMGNSFSNLLHINRESVLTDT 669

  Fly   706 YRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLE-------ETIKKVFDPSLNLFKT 763
            .:.| .|.|.:....::|.||.     |.|||..|:..||..       |..||:.:
Zfish   670 LQYL-RQNTHSFMHPLQVAFIG-----EDGIDMRGLSAEFFSLISKSFIEWDKKILE-------- 720

  Fly   764 TSDQRLYPSPISYVQDNHL---ELFEFVGRMLGKAVY--EGIVVDVPFASFFLSQLLGQTQQALY 823
                 ::.|.:.:...:|.   :.|.::|.:.|.|:|  ..|.:|.|.|.|  .:||.|...
Zfish   721 -----VHESSLVWFNPHHTRGNKNFYYLGVICGMALYNRHHINIDFPLALF--KKLLQQKPS--- 775

  Fly   824 SCMDELPSLDNELYRSL-TFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKL 887
              :|:|..|.....||| ..::..:::|.:|.   .:|....|:    .|.|.|....||..|:.
Zfish   776 --LDDLEELSPVEARSLKNLLEEDEEEVVNLQ---HLDFTCKGQ----ELVPNGSQIQVNKVNRQ 831

  Fly   888 VYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSP-LDLKDLQKHTH 951
            .|:........|..::.|...|.|||......:..::|.|.|||.|:.|  || .:.|:||:...
Zfish   832 KYVDLYVDLEFNKSVKTQFEQFTRGFSKGCPLDAWTMFHPEELQELLHG--SPQYNWKELQQSAS 894

  Fly   952 YYGGFHDTHQVVCWLWDILAKDF-------TEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCV 1009
            |.|         |...|.|.|:|       :||.:|.||.|:....:.|..|       .|.|.:
Zfish   895 YEG---------CSASDELIKNFWTVFFELSEENKKKFLMFLYGTERVPAGG-------LSKRAL 943

  Fly  1010 EVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSS 1071
            ::|..:                 ..||.:.||.:.|||..|.||.|...:||.|||.:|::|
Zfish   944 KISQTD-----------------CPDPDDHLPEAQTCFERLVLPKYSDINTLHDKLIHAINS 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	105/399 (26%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	99/375 (26%)
herc5.4	XP_005160166.1	RCC1_2	117..146	CDD:290274
		RCC1	133..183	CDD:278826
		RCC1	186..235	CDD:278826
		RCC1	239..286	CDD:278826
		RCC1	294..343	CDD:278826	16/69 (23%)
		HECTc	658..993	CDD:294058	105/399 (26%)
		HECTc	682..992	CDD:214523	99/374 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810