DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and herc5.3

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_021330683.1	Gene:	herc5.3 / 100073325	ZFINID:	ZDB-GENE-070615-14	Length:	1002	Species:	Danio rerio

Alignment Length:	835	Identity:	198/835 - (23%)
Similarity:	321/835 - (38%)	Gaps:	210/835 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 FGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLL--TETTTSLLELIPNTVTTKGVFTQWHE 367
            ||..|.|.     |||        |:...:.:..|:|  ||.|...:|        |.:..:.|.
Zfish   303 FGCGMQGQ-----LGN--------GEQVKQSVPLPVLLPTECTEFTME--------KLIAGENHS 346

  Fly   368 L-LGWHTPGPE---PAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSI 428
            . |.:.:||.|   |....|..:               |.|.|.:      .:|...:|...|:|
Zfish   347 FALFFKSPGNESEKPKSGSNGGI---------------LTLNDRI------IDRWVSESDPWPTI 390

  Fly   429 SNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILT 493
            .|.:....  ||...:|...:.:|:....|         ..|.| ||:.:..:.| |..||....
Zfish   391 KNEINTVF--SSAASLNGSFLKTSRDEHYQ---------TSVER-CGLDFDLVKT-SFAKLSTSK 442

  Fly   494 GICYSDNVLYDIWLLITSLGPNC----GMKEYLELLKSETNLQKPQTAM-------LMLFCDCMT 547
            .: .|:.|......|:.||.||.    .::.||.|.:....|:|.:|.:       ::..|....
Zfish   443 SL-ISEVVKVVQQTLLPSLNPNPTGEEALRLYLLLPELINGLKKQRTKLIEALAFKILELCPAAR 506

  Fly   548 HYVTILDEHEMYTEQNPFKLNDY--VLLTYF-------LNNILYKLINDNLLAGAKNIVQHPVFL 603
            ..:      |||..:.|   :|:  .|:..|       :..|.....:|......||.::
Zfish   507 KVL------EMYWSRLP---DDWFEALIKLFHKESAELIKQISRGETDDQSTRHLKNFLE----- 557

  Fly   604 SLHTLMLCLYRRDCRRPFTPPKH-WLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKL 667
                ::...|:..|....|  .| ::||||  :..:..|:......:.:.:::|......:|:||
Zfish   558 ----ILQMAYQICCSTNIT--NHDFIIPEV--NDLLETLDATSAEVLWMASRLPINEELHNRMKL 614

  Fly   668 ----FR--------KFVQN---EKAVMGLTESACASPRSALIVIH---------RDRIVEDGYRQ 708
                |:        .||.:   :|::..|.:..|......|:|:|         |:.::.|..:.
Zfish   615 EDYYFKTAEILVKFPFVSDFLTKKSMFILLQEQCIRSLLDLLVVHLNGNLLHINRESVLTDTLQY 679

  Fly   709 LAAQP-TQALKGVIRVRFINQQGLHEAGIDQDG---VFKEFLE--ETIKKVFDPSLNLFKTTSDQ 767
            |  :| |.:....::|.||.:..:.|..|..:.   :.|.|:|  :.|.:|.:.||..|..
Zfish   680 L--RPFTYSFMHPLQVAFIGEDEIDEKVISAEFFSLISKSFIEWDKKILEVHESSLVWFNP---- 738

  Fly   768 RLYPSPISYVQDNHLELFEFVGRMLGKAVY--EGIVVDVPFASFFLSQLLGQTQQALYSCMDELP 830
                   .:.|| |.: |.::|.:.|.|:|  ..|.:|.|.|.|  .:||.|...     :|:|.
Zfish   739 -------HHTQD-HRD-FYYLGVICGMALYNRHHINIDFPLALF--KKLLQQKPS-----LDDLE 787

  Fly   831 SLDNELYRSL-TFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMA 894
            .|.....||| ..::..:::|.||.   .:|....|:    .|.|.|....||..|:..|:....
Zfish   788 ELSPVEARSLKNLLEEDEEEVVDLQ---HLDFTCKGQ----ELVPNGSQIQVNKVNRQKYVDLYV 845

  Fly   895 FFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSP-LDLKDLQKHTHYYGGFHD 958
            .|..|..::.|...|..||......:..::|.|.|||.|:.|  || .:..:||:...|.|
Zfish   846 DFVFNKSVKTQFEQFTEGFSEGCPLDAWTMFHPEELQELLHG--SPQYNWNELQQSASYEG---- 904

  Fly   959 THQVVCWLWDILAKDF-------TEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDED 1016
                 |...|.|.|:|       :||.:|.||.|:....:.|..|       ||.|.:::|..:
Zfish   905 -----CSASDELIKNFWTVFFELSEENKKKFLMFLYGTERVPAGG-------FSKRALKISQTD- 956

  Fly  1017 TGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSS 1071
                            ..||.:.||.:.|||..|.||.|...:||||||.:||:|
Zfish   957 ----------------CPDPDDHLPEAQTCFERLVLPKYSDINTLRDKLIHAVNS 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	110/404 (27%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	103/370 (28%)
herc5.3	XP_021330683.1	RCC1	<74..349	CDD:332518	16/66 (24%)
herc5.3	XP_021330683.1	HECTc	665..1000	CDD:331829	108/395 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910