DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and wwp2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001090841.1	Gene:	wwp2 / 100038252	XenbaseID:	XB-GENE-961516	Length:	729	Species:	Xenopus tropicalis

Alignment Length:	391	Identity:	114/391 - (29%)
Similarity:	181/391 - (46%)	Gaps:	35/391 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 ASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIK 751
            |.|....|.:.|..:.||.::|:.......|:   |..:|..:|  |.|:|..|:.:|:......
Frog   369 ALPSHVKISVSRQTLFEDSFQQIMNMKPYDLR---RRLYIIMRG--EEGLDYGGIAREWFFLLSH 428

  Fly   752 KVFDPSLNLFKTTSDQR--LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQL 814
            :|.:|...||:......  |..:|.|.:..:||..|.|:||.:..|:|.|..:|..|...|..::
Frog   429 EVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRM 493

  Fly   815 LGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKAR 879
            |.:.     ..:.:|.|:|.|.|.|:.:||....:..:|.|.|..|.:::|::.:..|..||:..
Frog   494 LNKK-----PTLRDLESIDPEFYNSIMWIKDNNLEECELELYFVQDMEILGEVTSHKLKEGGENI 553

  Fly   880 VVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLK 944
            .|.:.||..:|..:..:.....:.|||.||..||:.:|..|||..|...||:.::.| ...:|:.
Frog   554 RVTEENKEEFISLLTDWRFTRGVEEQTNAFLDGFKEVVPLEWLRYFDEKELELMLCG-MQEIDIA 617

  Fly   945 DLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCV 1009
            |.||:|.|.....::.||. |.|.:: |:...|:|...|:|||...:.|:.||..|
Frog   618 DWQKNTIYRHYTKNSKQVQ-WFWQVV-KEMDNEKRIRLLQFVTGTCRLPVGGFVEL--------- 671

  Fly  1010 EVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTG 1074
                       |||.....|.|.:......||.|.||||.|.||.|:....|::||.:|:....|
Frog   672 -----------IGSNGPQKFCIDRVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEG 725

  Fly  1075 F 1075
            |
Frog   726 F 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	112/384 (29%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	104/358 (29%)
wwp2	NP_001090841.1	WW	160..189	CDD:366073
		WW	190..219	CDD:366073
		WW	265..293	CDD:366073
		WW	305..335	CDD:238122
		HECTc	375..727	CDD:238033	112/385 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910