Protein Alignment smg and Samd4

DIOPT Version :9

• Sequence 1: NP_001137924.1
• Gene: smg / 39034
• FlyBaseID: FBgn0016070
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: XP_006519690.1
• Gene: Samd4 / 74480
• MGIID: 1921730
• Length: 761
• Species: Mus musculus
• Alignment Length: 932
• Identity: 213/932 - (22%)
• Similarity: 343/932 - (36%)
• Gaps: 273/932 - (29%)

  Fly    73 LFCEQVTTVTNLFEKWNDCERTVVMYALLKRLRYPSLKFLQYSIDSNLTQNLGTSQTNLSSVVID 137
            :|.:||..:...|:.||:||:||.:.:||||:.....:|||..::.:|..   .::.:    |::
Mouse     2 MFRDQVGVLAGWFKGWNECEQTVALLSLLKRVSQTQARFLQLCLEHSLAD---CAELH----VLE 59

  Fly   138 INANNPVYLQNLLNAYKTFQPCDLLDAMSSSSSDKDSMPCYGSDFQITTSAQCDERKLYARKEDI 202
            ..||:|    .::|.::            ..|.||                             :
Mouse    60 GEANSP----GIINQWQ------------QESKDK-----------------------------V 79

  Fly   203 LHEVLNMLPLLKPGNEEAKLIYLTLIPVAVKDTMQQIVPTELVQQIFSYLLIHPAITSEDRRSLN 267
            :..:|..||||||||.:||..|:.|:|..:..:::.....|..:|:.||.|||||.:.|||.:|.
Mouse    80 ISLLLTHLPLLKPGNLDAKAEYMKLLPKILAHSIEHNQHIEESRQLLSYALIHPATSLEDRSALA 144

  Fly   268 IWLRHLEDHIQAAAAGLTNRSYFLQPSPQLVAGGSSTGSGSCSSSATSSSTASCSSVASSSLCPA 332
            :||.||||.        |:.|:          |..:.|.   |.|.....|.......:|
Mouse   145 MWLNHLEDR--------TSTSF----------GSQNRGR---SDSVDYGQTHYYHQRQNS----- 183

  Fly   333 SGSRSSRTNDWQTIAPPSKQLQNKLAGDWRGNGGGSSSGSINPLCDNLNGITLNELASSQNSLGL 397
                ..:.|.||........:.   |.:|:....|..:|.: ||..:      :.:.::.|::|
Mouse   184 ----DDKLNGWQNSRDSGICIS---ASNWQDKSLGCENGHV-PLYSS------SSVPATINTIG- 233

  Fly   398 SLEGSSSLVNGVVAGAGSMLGIAGGDDHDTSFS--KNGTEILDFDPVTADMGEACSLASSSLCGR 460
              .|:|:...|..:...|:.|        .|:|  .|..|.           :.|..:....||.
Mouse   234 --TGASTSTTGPTSSGQSLFG--------KSYSVVSNSLEF-----------QLCRGSPIWKCGH 277

  Fly   461 NGGNPVE-------DRSQPPPNLQQQLLQPPPYASILMGNVGDQ-FGEINRWSLDSKIAALKTRR 517
            ....|.|       .::...|..:...|.||.       ||.:| .|  :.|.....:.|...:
Mouse   278 TWPAPFEVPTRVLSGQAHHSPLKRSVSLTPPM-------NVPNQPLG--HGWMSHEDLRARGPQ- 332

  Fly   518 SNSLTTQTISSCSSSSNSSVITVNDNCSNSTENLAQFANKPRSFSLSIEHQRGALMNSGSDTRLD 582
                       |..|.::                      |.|...|:     |...||....|:
Mouse   333 -----------CLPSDHA----------------------PLSPQSSV-----ASSGSGGSEHLE 359

  Fly   583 EFKPNYIKFHTRNVGMSGIGLWLKSLRLHKYIELFKNMTYEEMLLITEDFLQSVGVTKGASHKLA 647
            :.......|.....||..:..||||||||||..||..||||||:.:||..|::..|||||.||:.
Mouse   360 DQTTARNTFQEEGSGMKDVPAWLKSLRLHKYAALFSQMTYEEMMALTECQLEAQNVTKGARHKIV 424

  Fly   648 LCIDKLKERANILNRVEQELLSGQMELSTAVEELTNIVLTPMKP-----------------LESP 695
            :.|.|||||.|:|..:|::::.|. .|.|.::||..::|||:|.                 :|||
Mouse   425 ISIQKLKERQNLLKSLERDIIEGG-SLRTPLQELHQMILTPIKAYSSPSTTPEVRCREPSLMESP 488

  Fly   696 GP-----------------------------------------PEENIGLRFLKVI-DIVTNTLQ 718
            .|                                         ||.::..:|.:|: .:.|..|.
Mouse   489 SPDCKDSAAAVTSATASASAGASGGLQPPQLSSCDGELAVAPLPEGDLPGQFTRVMGKVCTQLLV 553

  Fly   719 QDPYAVQDDETLGVLMWILDRSIHNEAF--------MNHASQLKDLKFKLSKMKISMVPKMHHVK 775
            ..|    |:|.:...:.:||:.:.:|||        ::...|::.|.....:..:..:......:
Mouse   554 SRP----DEENISSYLQLLDKCLVHEAFTETQKKRLLSWKQQVQKLFRSFPRKTLLDISGYRQQR 614

  Fly   776 PAGVGPNNG-------NINKPRWNGKTRKCDTKNGSNDRINNRKNSNDMLNFSLNCLPHPLPHHS 833
            ..|.|.:|.       .....|.|.:..:..::|..:.|:.....|..:   |.|      ..|:
Mouse   615 NRGFGQSNSLPTASSVGSGMGRRNPRQYQIASRNVPSARLGLLGTSGFV---SSN------QRHT 670

  Fly   834 QQAPPPLPQFDYNGYGGGPSHQPQYKSSSYPSFMGNPQQQPPPPPSSKSHHHPQQMQQMLQQHNH 898
            ...|..:.|...|.:...|.     .|:|.||...:..|:....|   .|..||.|....|....
Mouse   671 AANPTIMKQGRQNLWFANPG-----GSNSMPSRTHSSVQKTRSLP---VHTSPQNMLMFQQPEFQ 727

  Fly   899 FPALPQQTPPQSHRRSLNNLIL 920
            .|.    |.|..:.| |.:|.|
Mouse   728 LPV----TEPDINNR-LESLCL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smg	NP_001137924.1	SAM_Smaug	597..655	CDD:188956	33/57 (58%)
		SAM	601..656	CDD:197735	32/54 (59%)
		PHAT	656..763	CDD:204178	33/173 (19%)
Samd4	XP_006519690.1	SAM_Smaug	370..432	CDD:188956	33/61 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839694
Domainoid	1	1.000	71	1.000	Domainoid score	I9406
eggNOG	1	0.900	-	-		E1_KOG3791
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	192	1.000	Inparanoid score	I3848
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S6281
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D297836at33208
OrthoFinder	1	1.000	-	-		FOG0002446
OrthoInspector	1	1.000	-	-		otm43572
orthoMCL	1	0.900	-	-		OOG6_106131
Panther	1	1.100	-	-	O	PTHR12515
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1666
SonicParanoid	1	1.000	-	-		X2618
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.830