Protein Alignment smg and ZCCHC2

DIOPT Version :9

• Sequence 1: NP_001137924.1
• Gene: smg / 39034
• FlyBaseID: FBgn0016070
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_060212.4
• Gene: ZCCHC2 / 54877
• HGNCID: 22916
• Length: 1178
• Species: Homo sapiens
• Alignment Length: 768
• Identity: 143/768 - (18%)
• Similarity: 230/768 - (29%)
• Gaps: 296/768 - (38%)

  Fly   533 SNSSVITVNDNCSNSTENLAQFANK-PRSFSLSIEHQRGAL--MNSGSDTRLDEFKPNYIKFHTR 594
            |:.||.||    :.:.:.|.:|..| |:..| |....:..|  :|.||..|.:...|: ::...|
Human   380 SDLSVTTV----TKTHQELQEFLLKLPKELS-SETFDKTILRALNQGSLKREERRHPD-LEPILR 438

  Fly   595 NVGMSGIGLWLKSLRLHKYIELFKNMTYEEMLLITEDFLQSVGVTKGASHKLALCIDKLKERANI 659
            .:..|....:|:|.::|.:.:           .|:.|.|.|:...: :|.|.:..::.|||.::.
Human   439 QLFSSSSQAFLQSQKVHSFFQ-----------SISSDSLHSINNLQ-SSLKTSKILEHLKEDSSE 491

  Fly   660 LNRVEQELLSGQM--ELSTAVEELTNIVLTPMKPLESPGPPEENIGLRFLKVIDIV------TNT 716
            .:..|:::|...:  :..|....:.|.:.|...||       :.:.:::.:...||      ..|
Human   492 ASSQEEDVLQHAIIHKKHTGKSPIVNNIGTSCSPL-------DGLTMQYSEQNGIVDWRKQSCTT 549

  Fly   717 LQQDPYAV-------------------------------QDDETLGVLMWILDRSIHNEAFMNHA 750
            :|...:.|                               :.|..|...:..:..|....|   |.
Human   550 IQHPEHCVTSADQHSAEKRSLSSINKKKGKPQTEKEKIKKTDNRLNSRINGIRLSTPQHA---HG 611

  Fly   751 SQLKDLKFKL----------SKMKISMVPKMHH-------------------------------- 773
            ..:||:...:          |....|......|
Human   612 GTVKDVNLDIGSGHDTCGETSSESYSSPSSPRHDGRESFESEEEKDRDTDSNSEDSGNPSTTRFT 676

  Fly   774 ----------VKP----AGVGPNNGN-----INKPRWNG----KTRKCDTKNGSN---------- 805
                      |||    |.:|..|||     :|.|::..    .|..|...||:.
Human   677 GYGSVNQTVTVKPPVQIASLGNENGNLLEDPLNSPKYQHISFMPTLHCVMHNGAQKSEVVVPAPK 741

  Fly   806 -----------------DRINNRKNSNDM---------------LNFSLNCLPHP---LPHHSQQ 835
                             ..|....||..:               |....:.||.|   |||.|..
Human   742 PADGKTIGMLVPSPVAISAIRESANSTPVGILGPTACTGESEKHLELLASPLPIPSTFLPHSSTP 806

  Fly   836 A----------PPPLPQFDYNGYGGG-------PSHQPQYKSSSYPSF----MGNPQQQPPPP-- 877
            |          |||        .|..       |...|...|.:.|:.    :.||...|..|
Human   807 ALHLTVQRLKLPPP--------QGSSESCTVNIPQQPPGSLSIASPNTAFIPIHNPGSFPGSPVA 863

  Fly   878 ---PSSKSHHHPQQMQQMLQQ-HNHFPALPQQTPPQSHRRSLNNLILVAGG--PQQPQQLIFKPG 936
               |.:||......:.||:.| ..:...:||.|..:        ::|.|.|  ..||......||
Human   864 TTDPITKSASQVVGLNQMVPQIEGNTGTVPQPTNVK--------VVLPAAGLSAAQPPASYPLPG 920

  Fly   937 Q----GVLTNNGSNDNLVLERNQQSQQQQQQRKLSGGVSSAEQQPKKTMAAVVMVSNP------- 990
            .    |||.:..|:   ||.....|.|     ..|.|:|.|:    .|:...|....|
Human   921 SPLAAGVLPSQNSS---VLSTAATSPQ-----PASAGISQAQ----ATVPPAVPTHTPGPAPSPS 973

  Fly   991 ---NQNQDQHDQPQILINNNNNNSMLNNNLINQQQLQLLAAAAAAVGSGSC-----LCSNGGGG- 1046
               ..:..|.|....:....|.|:  |..::..||:          |||.|     .||.|..|
Human   974 PALTHSTAQSDSTSYISAVGNTNA--NGTVVPPQQM----------GSGPCGSCGRRCSCGTNGN 1026

  Fly  1047 ---------------------------ACVHNICHQSSKNNNHGVDHCLSQSP 1072
                                       .|..:..:|:.::|.:.:...|.|:|
Human  1027 LQLNSYYYPNPMPGPMYRVPSFFTLPSICNGSYLNQAHQSNGNQLPFFLPQTP 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smg	NP_001137924.1	SAM_Smaug	597..655	CDD:188956	11/57 (19%)
		SAM	601..656	CDD:197735	11/54 (20%)
		PHAT	656..763	CDD:204178	20/155 (13%)
ZCCHC2	NP_060212.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..249
		PX_domain	363..461	CDD:295365	22/97 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	557..683		11/128 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	936..986		12/58 (21%)
		zf-CCHC	1133..1148	CDD:278525

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900