DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smg and Zcchc14

DIOPT Version :9

Sequence 1:	NP_001137924.1	Gene:	smg / 39034	FlyBaseID:	FBgn0016070	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	XP_344781.5	Gene:	Zcchc14 / 365018	RGDID:	1309494	Length:	1087	Species:	Rattus norvegicus

Alignment Length:	975	Identity:	187/975 - (19%)
Similarity:	325/975 - (33%)	Gaps:	300/975 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 DINANNPVYLQNLLNAYKTFQPCDLLDAMSSSSSDKDSMPCYGSDFQITTSAQCDERKLYARKED 201
            :|.||||..|.:|.|.........||.:::...|::  ....|..::..|           ..:.
  Rat    63 EIKANNPADLGSLTNLTDEVVRSKLLVSLALLGSEQ--REAAGVLYRTLT-----------HTDS 114

  Fly   202 ILHEVLNMLPLLKPGNEEAKLIYLTLIPVAVKDTMQQIVPTELVQQIFSYLLIHPAITSEDRRSL 266
            |:|.....|...:.|:|     :|.|..:|..                     |||.:...::.|
  Rat   115 IIHNYGLQLNEGRTGDE-----FLLLFTMASN---------------------HPAFSFHQKQVL 153

  Fly   267 NIWLRHLEDHIQAAAAGLTNRSYFLQPSPQLVAGGSSTGSGSCSSSATSSSTASCSS---VASSS 328
            ...|..::..:....                 .||...|.|..|:...|.:..:||:   :|..:
  Rat   154 RQELTQIQSSLNGGG-----------------GGGGGGGGGGKSAPGPSGALPTCSACHKMAPRT 201

  Fly   329 LCPASGSRSSRTNDWQTIAPPSKQLQNKLAGDWRGNGGGSSSGSINPLCDNLNGITLNELASSQN 393
            ..|.|...:|..|...|.|..:::...|     |..|   ..|.:     ::..|.|..|:.:::
  Rat   202 ETPVSSISNSLENALHTSAHSTEEALPK-----RPLG---KHGKV-----SVEKIDLKGLSHTKS 253

  Fly   394 SLGL--SLEGSSSLVNGVVAGAGSMLGIAGGDDHDTSFSKNGTEILDFDPVTADMGEAC---SLA 453
            ..|:  |.|                  :...|...||.:|:.:|:.:|   .:.:.:.|   :|.
  Rat   254 DRGVECSFE------------------VLWSDSSVTSVTKSSSEVTEF---ISKLSQLCPEENLD 297

  Fly   454 SSSLCGRNGGNPVEDR-------------SQPPPNLQ--------------QQLLQPPPYASILM 491
            ....|.....:...:|             |.|...|:              |||..|.|
  Rat   298 KLIPCLAGPDSFYVERNHVDLEAGLRFLASIPAHTLKHDHVRKFFSASSPSQQLQSPSP------ 356

  Fly   492 GN-----VGDQFGEINRWSLDSKIAALKTRRSNSLTTQTISSCSSSSNSSVITVNDNCSNSTENL 551
            ||     ||...|...|     .:..:....|:..:||.....|:||::|:    .:||::..
  Rat   357 GNPSPPKVGAMMGVSGR-----PVCGVAGIPSSQSSTQHHLQHSASSSASL----PHCSHTGG-- 410

  Fly   552 AQFANKPRSFSLSIEHQRGALMNSGSDTRLDEFKPNYIKFHTRNVGMSGIGLWLKSLRLHKYIEL 616
               |....::...:::....||.||    |...:|.         ..:||..||:.||||||..:
  Rat   411 ---AGPALAYRTQVDNSPTILMPSG----LQAPQPQ---------EQNGILDWLRKLRLHKYYPV 459

  Fly   617 FKNMTYEEMLLITEDFLQSV-GVTKGASHKLALCIDKLKERANILNRVEQELLSGQMELSTAVEE 680
            ||.:|.|:.|.:||:.|... .:|.||..||...::..||::      |:..|:     |:|...
  Rat   460 FKQLTMEKFLSLTEEDLNKFESLTMGAKKKLKTQLELEKEKS------ERRCLN-----SSAPSL 513

  Fly   681 LTNIVLTPMKPLESPGPPEENIGLRFLKVIDIVTNTLQQDPYAVQDDETLGVLMWILDRSIHNEA 745
            :|:..:..:.|....||.:..                                     ||
  Rat   514 VTSSGVARVTPTSHVGPVQPG-------------------------------------RS----- 536

  Fly   746 FMNHASQLKDLKFKLSKMKISMVPKMHHVKPAGVGPNNGNINKPRWNGKTRKCDTKNGSNDRINN 810
              :|||:|          ::.:.|..|.:              || .|.:.:..:.:.|...:..
  Rat   537 --SHASEL----------RVEVEPPAHQL--------------PR-EGSSSEYSSSSSSPMGVQA 574

  Fly   811 RKNSNDMLNFSLNCLPHPLPHHSQQAPPPLPQFDYNGYGGGPSHQPQYKSSSYPSFMGNPQQQPP 875
            |:.|:|....|    ...:..|.:               |....:|....:.:||....|..|..
  Rat   575 REESSDSAEES----DRRVDIHVE---------------GTEKEKPVMLLAHFPSSSARPTAQVL 620

  Fly   876 P----PPSSKSHHHPQQMQQMLQQHNHFPALPQQTPPQSHRRSLNNLILVAGGPQQPQQL----- 931
            |    ..||.:.|||...|.|       ||.|...|.    |.||::.....|....:.|
  Rat   621 PVQNETGSSPAGHHPLPAQLM-------PAAPHLAPV----RMLNSVHKSDRGSTDVKLLSSSVH 674

  Fly   932 ----IFKPGQGVLTNNG-----SNDNLVLERNQQSQQQQQQRKLSGGVSSAEQQPKKTM---AAV 984
                :.:.|:|....:|     |....||:....:......:.|||.|.:....|..:.   |.|
  Rat   675 SLLSLEERGKGPAPRSGTKVDKSFGGAVLDTLPSAAPHPPVQGLSGLVENTSVSPNVSFGPRAKV 739

  Fly   985 VMVSNPNQNQDQHDQPQILINNNNNNSMLNNNLIN--QQQLQLLAAAAAAVG---SGSCLCSNGG 1044
            |..:..::......||.:.:..::..:...:.:::  :..::||.:::....   ||...|.|.|
  Rat   740 VHAATLDRVLKTAQQPALTVETSSAATGTPSTVLHVARPPIKLLLSSSVPADTAISGQTSCPNNG 804

Fly 1045 1044
Rat 805 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smg	NP_001137924.1	SAM_Smaug	597..655	CDD:188956	23/58 (40%)
		SAM	601..656	CDD:197735	23/55 (42%)
		PHAT	656..763	CDD:204178	14/106 (13%)
Zcchc14	XP_344781.5	PX_domain	261..342	CDD:295365	14/101 (14%)
		SAM_ZCCH14	437..501	CDD:188957	26/72 (36%)
		SAM	444..495	CDD:197735	22/50 (44%)
		zf-CCHC	1046..1061	CDD:278525
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900