DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smg and Samd4b

DIOPT Version :9

Sequence 1:	NP_001137924.1	Gene:	smg / 39034	FlyBaseID:	FBgn0016070	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_001100968.1	Gene:	Samd4b / 308473	RGDID:	1305597	Length:	687	Species:	Rattus norvegicus

Alignment Length:	907	Identity:	202/907 - (22%)
Similarity:	307/907 - (33%)	Gaps:	379/907 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LFCEQVTTVTNLFEKWNDCERTVVMYALLKRLRYPSLKFLQYSIDSNLTQ----NLGTSQTNLSS 133
            :|.:||..:.:.|:.||:||:||.:.:||||:.....:|||..::.:|..    :|..|:.|.::
  Rat     2 MFRDQVGILASWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLESEANSAA 66

  Fly   134 VVIDINANNPVYLQNLLNAYKTFQPCDLLDAMSSSSSDKDSMPCYGSDFQITTSAQCDERKLYAR 198
            :|                                |...::|
  Rat    67 IV--------------------------------SQWQQES------------------------ 75

  Fly   199 KEDILHEVLNMLPLLKPGNEEAKLIYLTLIPVAVKDTMQQIVPTELVQQIFSYLLIHPAITSEDR 263
            ||.::..:|:.||||:|||.|||..|:.|:...:..:::.....|..:|:.||.|||||.|.|||
  Rat    76 KEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDR 140

  Fly   264 RSLNIWLRHLEDHIQAAAAGLTNRSYFLQPSPQLVAGGSSTGSGSCSSSATSSSTASCSSVASSS 328
            .:|.:||.|||:.:   |:|...|.   :||.....|....|.
  Rat   141 NALALWLSHLEERL---ASGFRTRP---EPSYHSRQGSDEWGG---------------------- 177

  Fly   329 LCPASGSRSSRTNDWQTIAPPSKQLQNKLAGDWRGNGGGSSSGSINPLCDNLNGITLNELASSQN 393
              ||..:.....:.||. .||.:          .|:.....|.|:.|        .:|.:.|:.|
  Rat   178 --PAELAPGEAGSGWQD-KPPRE----------NGHVPFHPSSSVPP--------AINSIGSNAN 221

  Fly   394 SLGLSLEGSSSLVNGVVAGAGSMLGIAGGDDHDTSFSKNGTEILDFDPVTADMGEACSLASSSLC 458
            :                                                    |..|.:..|
  Rat   222 T----------------------------------------------------GLPCQIHPS--- 231

  Fly   459 GRNGGNPVEDRSQPPPNLQQQLLQPPPYASILMGNVGDQFGEINRWSLDSKI---AALKTRRSNS 520
                          |......|:...|.|.          ||   |....::   ||..|.....
  Rat   232 --------------PLKRSMSLIPTSPQAP----------GE---WPSPEELGARAAFTTPDHAP 269

  Fly   521 LTTQTISSCSSSSNSSVITVNDNCSNSTENLAQFANKPRSFSLSIEHQRGALMNSGSDTRLDEFK 585
            |:.|  ||.:||.           |..||                  ::|:..|:
  Rat   270 LSPQ--SSVASSG-----------SEQTE------------------EQGSSRNT---------- 293

  Fly   586 PNYIKFHTRNVGMSGIGLWLKSLRLHKYIELFKNMTYEEMLLITEDFLQSVGVTKGASHKLALCI 650
                 |.....||..:..||||||||||..||..|:||||:.:||..|:|..|||||.||:||.|
  Rat   294 -----FQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSI 353

  Fly   651 DKLKERANILNRVEQELLSGQMELSTAVEELTNIVLTPMK------------------------- 690
            .||:||.::|..:|:::|.|. .|..|::||..|::||:|
  Rat   354 QKLRERQSVLKSLEKDVLEGG-NLRNALQELQQIIITPIKAYSVLQATPTAKDGGRGEPLLPGAE 417

  Fly   691 -PLESPG----------PPEEN------------------------IGLRFLKVI-DIVTNTLQQ 719
             ||..||          |..||                        |..:|.:|: .:.|..|..
  Rat   418 PPLTHPGSDKGTEAKDPPAAENYPPPPAPAPSDSSEPAPAPVADGDIPSQFTRVMGKVCTQLLVS 482

  Fly   720 DPYAVQDDETLGVLMWILDRSIHNEAF-----------------------------MNHASQLKD 755
            .|    |:|.:...:.::::.:.:|||                             |....|.|.
  Rat   483 RP----DEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLLRTFPRKAALDMQSYRQQKG 543

  Fly   756 LKFKLSKMKIS----------------MVP------KMHHVKPAGVG---PNNGNINKPRWNGKT 795
            ..|..:.:.|:                |.|      :|..:.|:|:|   |.:. :..|...|:.
  Rat   544 WAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHA-LTSPSLGGQG 607

  Fly   796 RKCDTKNGSNDRINNRKNSNDMLNFSLNCL--PHPLP-HHSQQA--------PPPLPQFDYN 846
            |:       |....|...||.|.:.|.:.:  .|.|| |.|.||        |.|.|..:.|
  Rat   608 RQ-------NLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEIN 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smg	NP_001137924.1	SAM_Smaug	597..655	CDD:188956	35/57 (61%)
		SAM	601..656	CDD:197735	33/54 (61%)
		PHAT	656..763	CDD:204178	35/196 (18%)
Samd4b	NP_001100968.1	SAM_Smaug	296..358	CDD:188956	35/61 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343517
Domainoid	1	1.000	71	1.000	Domainoid score	I9239
eggNOG	1	0.900	-	-		E1_KOG3791
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3797
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D297836at33208
OrthoFinder	1	1.000	-	-		FOG0002446
OrthoInspector	1	1.000	-	-		otm45641
orthoMCL	1	0.900	-	-		OOG6_106131
Panther	1	1.100	-	-	LDO	PTHR12515
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2618
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.850