DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smg and ZC190.4

DIOPT Version :9

Sequence 1:	NP_001137924.1	Gene:	smg / 39034	FlyBaseID:	FBgn0016070	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_505233.2	Gene:	ZC190.4 / 179248	WormBaseID:	WBGene00022538	Length:	629	Species:	Caenorhabditis elegans

Alignment Length:	384	Identity:	83/384 - (21%)
Similarity:	148/384 - (38%)	Gaps:	101/384 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 PPNLQQQLLQPPPYASILMGNVGDQFGEINRWSLDSKIAAL----KTRRSNSLTTQTISSCSSSS 533
            |..|:.|||......||...|             |..:|:|    .|...|.....::|..|.|:
Worm    39 PEPLEDQLLMNMQNVSIYTTN-------------DLDLASLGIQSVTMTGNPWQPNSLSFGSVST 90

  Fly   534 NSSVITVNDNCSN-----STENLAQFANKPRSFSLSIEHQRGALMNSGSDTRLDEFKPN-----Y 588
            |.  .|.:|..|.     |:..|.:...:...|     ||:....|:.:.|..:.|:.|     :
Worm    91 NG--FTGSDTSSAPMSPISSPGLRKHHLQGNGF-----HQQHQKFNNKNQTHPNHFRNNRGNGGH 148

  Fly   589 IKFHTRNV---------------------------------GMSGIGLWLKSLRLHKYIELFKNM 620
            :..|.:|:                                 ||..:|.|||.||||||..||::|
Worm   149 LNGHQQNIQNSNRSGYNMGNNSQHTVVPTTRTIRTVDEHKPGMRDLGYWLKKLRLHKYAPLFQDM 213

  Fly   621 TYEEMLLITEDFLQSVGVTKGASHKLALCIDKLKERANILNRVEQELLSGQMELSTAVEELTNIV 685
            ||.::|.:.::.|:.:.||.||..|:|..|:||.||..:|..:||:|.:|...:..|:..:..::
Worm   214 TYRQLLSLNDNVLERMKVTNGARKKIAQSIEKLYERPALLRSLEQKLKTGTQCVRCAICSVRQLL 278

  Fly   686 LTPMKPLE-----------------SPGPPEENIGLRFLKVIDIVTNTLQQDPYAVQD--DETLG 731
            .:|....:                 |....::|:.....:||:.:.:.:......:.|  ||.|.
Worm   279 WSPFIKYDVGTRKTSTDIIDGFNVPSNMISDDNLPALIYRVIETLNHMIFPLRKGLMDFEDEYLL 343

  Fly   732 VLMWILDRSIHNEAF---------------MNHASQLKDLKFKLSKMKISMVPKMHHVK 775
            .:..:.:..:.||:|               .::|:..:..:.::..:..|.....||.:
Worm   344 TMFHMFESVMKNESFTPNQQRRAFLMKKNARSYANPEEIRRHRMGMVSSSQCEGCHHAE 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smg	NP_001137924.1	SAM_Smaug	597..655	CDD:188956	28/57 (49%)
		SAM	601..656	CDD:197735	26/54 (48%)
		PHAT	656..763	CDD:204178	20/140 (14%)
ZC190.4	NP_505233.2	SAM_Smaug	186..248	CDD:188956	28/61 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165668
Domainoid	1	1.000	59	1.000	Domainoid score	I7110
eggNOG	1	0.900	-	-		E1_KOG3791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002446
OrthoInspector	1	1.000	-	-		oto18383
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12515
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1666
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.920