DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5280 and C22orf23

DIOPT Version :9

Sequence 1:	NP_648278.1	Gene:	CG5280 / 39033	FlyBaseID:	FBgn0035952	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	XP_005261838.1	Gene:	C22orf23 / 84645	HGNCID:	18589	Length:	227	Species:	Homo sapiens

Alignment Length:	206	Identity:	62/206 - (30%)
Similarity:	110/206 - (53%)	Gaps:	29/206 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 VQYSKETADLIRLLVKESKMSMLVRKQIDESLRNGEPLPLPEPPRPNTNNDPDKETLA------I 115
            :.|:..|.:|:|:::||||::.:.::.|.:.::.|:.|||...|..:....|.|:..:      |
Human    23 ITYTPGTCELLRVMMKESKLTNIQQRHIMDIMKRGDALPLQCSPTSSQRVLPSKQIASPIYLPPI 87

  Fly   116 LDRARNAKRKNLR---QIEASGAYKQSYYRPPADNRMHGEKAKSQLQFTMA-GTHLPDPAIKPRR 176
            |     |.|.:||   ..:|:|||.:..::|.|...:  ||.|.:||...| |..:.:   :.|:
Human    88 L-----AARPHLRPANMCQANGAYSREQFKPQATRDL--EKEKQRLQNIFATGKDMEE---RKRK 142

  Fly   177 RP--REEQLVTEEDLINELLDQINERAEWLTEMESMGQGKKYR----PEIRDQIAERLRRI--QA 233
            .|  |::....|.|...||:.:|.||.|:|.:||::||||:||    .|| .|:.|..|::  ..
Human   143 APPARQKAPAPELDRFEELVKEIQERKEFLADMEALGQGKQYRGIILAEI-SQVGETTRKVGRGR 206

  Fly   234 LESKMKMKSNG 244
            .:.:::|:..|
Human   207 AQRQVRMEIQG 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5280	NP_648278.1	UPF0193	40..241	CDD:283026	60/201 (30%)
C22orf23	XP_005261838.1	UPF0193	6..194	CDD:283026	57/181 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160126
Domainoid	1	1.000	86	1.000	Domainoid score	I8142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5166
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52348
OrthoDB	1	1.010	-	-		D1195866at2759
OrthoFinder	1	1.000	-	-		FOG0007385
OrthoInspector	1	1.000	-	-		oto90899
orthoMCL	1	0.900	-	-		OOG6_106698
Panther	1	1.100	-	-	LDO	PTHR28348
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4558
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.900