DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5068 and PPE1

DIOPT Version :9

Sequence 1:	NP_001261609.1	Gene:	CG5068 / 39032	FlyBaseID:	FBgn0035951	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_011942.1	Gene:	PPE1 / 856474	SGDID:	S000001117	Length:	400	Species:	Saccharomyces cerevisiae

Alignment Length:	416	Identity:	105/416 - (25%)
Similarity:	168/416 - (40%)	Gaps:	112/416 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GGRIGRADSF--KKSRIRDY--KPG---------------MWNEFFAEKEDVTV-DEQRTFRIYR 63
            |..:|...||  :.:|.|.|  |.|               .|::||..||.|:: |.......|.
Yeast    36 GDALGSLPSFNGQSNRNRKYTGKTGSTTDRISSKEKSSLPTWSDFFDNKELVSLPDRDLDVNTYY 100

  Fly    64 TKQPEKPG-----PVLLLLHGGGYSALTWAHFCSEVTSMI--HCQCLCIDMRGHGDSKVDDEDD- 120
            |.......     |:.:..||.|.|.|::|:...|:.:.:  .|.|...|.|||.::|....|.
Yeast   101 TLPTSLLSNTTSIPIFIFHHGAGSSGLSFANLAKELNTKLEGRCGCFAFDARGHAETKFKKADAP 165

  Fly   121 --LSADTLAKDIGDLILKLYPEEVPQ-------LFVVGHSMGGAIAVHFAHMALVPNL----IGI 172
              ...|:..||...|:...:..::.|       :.::|||:||:|.. ||:..|...|    :||
Yeast   166 ICFDRDSFIKDFVSLLNYWFKSKISQEPLQKVSVILIGHSLGGSICT-FAYPKLSTELQKKILGI 229

  Fly   173 TVIDVVEGTAMEALASMQSFLRSRPKYFQSIPNAIEWCIRSGQVRNVDSAKVSMPGQIINCTTNK 237
            |::|:||..|:.||..::.||::.|..|:||.:|::|.::....|...||::::|
Yeast   230 TMLDIVEEAAIMALNKVEHFLQNTPNVFESINDAVDWHVQHALSRLRSSAEIAIP---------- 284

  Fly   238 LATNDLPLPDDVLEEAHHNSMFPNPFSISEDEESSPPGDDAADGSSESAAAGADFKKPNTTKSTT 302
                                                             |..|..|.....:.|
Yeast   285 -------------------------------------------------ALFAPLKSGKVVRIT- 299

  Fly   303 EAAKNYTWRIDLSKSEKYWVGWFSGLSDKFLNLRLPKQLLLASIDGLDRTLTVGQMQGRFQMQVL 367
                      :|.....:|..||:.||..|:.|.:.|.|:||..:.||:.|.||||||::|:.|.
Yeast   300 ----------NLKTFSPFWDTWFTDLSHSFVGLPVSKLLILAGNENLDKELIVGQMQGKYQLVVF 354

  Fly   368 ARCGHAVHEDRPHEVAEVISGYLIRN 393
            ...||.:.||.|.:.|..:..:..||
Yeast   355 QDSGHFIQEDSPIKTAITLIDFWKRN 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5068	NP_001261609.1	MhpC	70..>204	CDD:223669	45/154 (29%)
CG5068	NP_001261609.1	Abhydrolase_5	73..>161	CDD:289465	26/99 (26%)
PPE1	NP_011942.1	Abhydrolase_1	114..366	CDD:395444	83/322 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341964
Domainoid	1	1.000	144	1.000	Domainoid score	I987
eggNOG	1	0.900	-	-		E2759_KOG2564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6099
Inparanoid	1	1.050	156	1.000	Inparanoid score	I1080
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53813
OrthoFinder	1	1.000	-	-		FOG0004995
OrthoInspector	1	1.000	-	-		oto99484
orthoMCL	1	0.900	-	-		OOG6_102589
Panther	1	1.100	-	-	LDO	PTHR14189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R974
SonicParanoid	1	1.000	-	-		X3528
TreeFam	1	0.960	-	-
	15	14.790