DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5068 and ABHD11

DIOPT Version :9

Sequence 1:	NP_001261609.1	Gene:	CG5068 / 39032	FlyBaseID:	FBgn0035951	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	XP_024302717.1	Gene:	ABHD11 / 83451	HGNCID:	16407	Length:	434	Species:	Homo sapiens

Alignment Length:	356	Identity:	79/356 - (22%)
Similarity:	117/356 - (32%)	Gaps:	132/356 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 IYRTKQPEKPGPVLLLLHG---GGYSALT-WAHFCSEVTSMIHCQCLCIDMRGHGDSKVDDEDDL 121
            |.|...|.:|.   |...|   |..|:|. |.            |.|.:|.|.||||  ....|:
Human   186 ILRDCHPARPA---LQRRGHNPGACSSLAEWP------------QVLTVDARNHGDS--PHSPDM 233

  Fly   122 SADTLAKDIGDLILKLYPEEVPQL-----FVVGHSMGGAIAVHFA--HMALVPNLIGITVIDVVE 179
            |.:.:::|:.||:        |||     .||||||||..|:..|  ...||..||.:. |..||
Human   234 SYEIMSQDLQDLL--------PQLGLVPCVVVGHSMGGKTAMLLALQRPELVERLIAVD-ISPVE 289

  Fly   180 GTAMEALASMQSFLRSRPKYFQSIPNAIEWCIRSGQVRNVDSAKVSMPGQIINCTTNKLATNDLP 244
            .|.:...|:..:.:|:                            :::..::......|||
Human   290 STGVSHFATYVAAMRA----------------------------INIADELPRSRARKLA----- 321

  Fly   245 LPDDVLEEAHHNSMFPNPFSISEDEESSPPGDDAADGSSESAAAGADFKKPNTTKSTTEAAKNYT 309
                                   ||:.|....|.|             .:.:...:..|....:.
Human   322 -----------------------DEQLSSVIQDMA-------------VRQHLLTNLVEVDGRFV 350

  Fly   310 WRIDLSKSEKYWVGWFSGLSDKFLNLRLPKQLLLASIDGLDRTLTVGQMQ--------------G 360
            ||::|....::        .||.|.....::..|    |....|..|..|              .
Human   351 WRVNLDALTQH--------LDKILAFPQRQESYL----GPTLFLLGGNSQFVHPSHHPEIMRLFP 403

  Fly   361 RFQMQVLARCGHAVHEDRPHEVAEVISGYLI 391
            |.|||.:...||.:|.|||.:....|.|:|:
Human   404 RAQMQTVPNAGHWIHADRPQDFIAAIRGFLV 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5068	NP_001261609.1	MhpC	70..>204	CDD:223669	43/144 (30%)
CG5068	NP_001261609.1	Abhydrolase_5	73..>161	CDD:289465	31/96 (32%)
ABHD11	XP_024302717.1	Atrophin-1	<15..159	CDD:331285
ABHD11	XP_024302717.1	PRK10673	216..433	CDD:331147	67/308 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910