DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5068 and Abhd8

DIOPT Version :9

Sequence 1:	NP_001261609.1	Gene:	CG5068 / 39032	FlyBaseID:	FBgn0035951	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_071864.2	Gene:	Abhd8 / 64296	MGIID:	1918946	Length:	439	Species:	Mus musculus

Alignment Length:	344	Identity:	66/344 - (19%)
Similarity:	119/344 - (34%)	Gaps:	103/344 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RTMLKGKL----PPTI-------PGGRIGRADSFKKSRIRDYKPGMWNEFFAEKEDVTVDEQRTF 59
            |..|:|:.    ||..       |.|...||:.....|.|..:|         |..:.:|.::..
Mouse   103 RADLQGRSGSGDPPAALEVELAEPAGGDTRANPGSGRRRRPRRP---------KRTIHIDCEQRI 158

  Fly    60 RIYRTKQPEKPGPVLLLLHGGGYSALTWAHFCSEVTSMIHCQCLCIDMRGHGDSKVDDEDDLSAD 124
            ...:..|.:   .||..:||.|.|...|.........:.: :.:..|:.|||.|.....  .:|.
Mouse   159 TSCKGAQAD---VVLFFIHGVGGSLAIWKEQLDFFVRLGY-EVVAPDLAGHGASSAPQV--AAAY 217

  Fly   125 T---LAKDIGDLILKLYPEEVPQLFVVGHSMGGAIAVHFAHMALVPNLIGITVIDVVEG---TAM 183
            |   ||:|:..:..: |.::  :..::|||.|.:.....||.  .|:|:...:  ::.|   ||:
Mouse   218 TFYALAEDMRAIFTR-YAKK--RNVLIGHSYGVSFCTFLAHE--YPDLVHKVI--MINGGGPTAL 275

  Fly   184 EALASMQSFLRSRPKYFQSIPNAIEW----------------CIRSGQVRNVDS----------- 221
            |  .|:.|...........:...:.|                .::.|...||.|
Mouse   276 E--PSLCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQY 338

  Fly   222 ---------AKVSMPGQIINCTTNKLATNDLPLPDD-------------VLEEAHHNSMFPNP-- 262
                     |::::|..:::...:|.    :|:.:|             ::||..|..|...|
Mouse   339 WPEGDEVYHAELTVPVLLVHGMHDKF----VPVEEDQRMAEILLLAFLKLIEEGSHMVMLECPET 399

  Fly   263 -------FSISEDEESSPP 274
                   |.:.|.|..:.|
Mouse   400 VNTLLHEFLLWEPEPEAEP 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5068	NP_001261609.1	MhpC	70..>204	CDD:223669	32/139 (23%)
CG5068	NP_001261609.1	Abhydrolase_5	73..>161	CDD:289465	22/90 (24%)
Abhd8	NP_071864.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..148		7/34 (21%)
		MhpC	149..408	CDD:223669	49/277 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..439		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910