Protein Alignment CG5068 and PPME1

DIOPT Version :9

• Sequence 1: NP_001261609.1
• Gene: CG5068 / 39032
• FlyBaseID: FBgn0035951
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001258522.1
• Gene: PPME1 / 51400
• HGNCID: 30178
• Length: 400
• Species: Homo sapiens
• Alignment Length: 424
• Identity: 196/424 - (46%)
• Similarity: 279/424 - (65%)
• Gaps: 39/424 - (9%)

  Fly     1 MSSLQRTMLKGKLP--PTIPGGRIGRADSFKKSRI-----RDYKPGMWNEFFAEKEDVTVDEQR- 57
            ||:|:::|..|:||  |.:||.  |.:.|..|.|:     ||:.|..|:::|...|||.|:.:.
Human     1 MSALEKSMHLGRLPSRPPLPGS--GGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETG 63

  Fly    58 --TFRIYRTKQPEKPGPVLLLLHGGGYSALTWAHFCSEVTSMIHCQCLCIDMRGHGDSKVDDEDD 120
              |||:|::   ...|||||||||||:|||:||.|.:.:.|.:.|:.:.:|:|.||::||.:.:|
Human    64 KDTFRVYKS---GSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRSHGETKVKNPED 125

  Fly   121 LSADTLAKDIGDLILKLYPEEVPQLFVVGHSMGGAIAVHFAHMALVPNLIGITVIDVVEGTAMEA 185
            |||:|:|||:|:::..:|.:..|.:.::|||||||||||.|...|||:|:|:.:|||||||||:|
Human   126 LSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDA 190

  Fly   186 LASMQSFLRSRPKYFQSIPNAIEWCIRSGQVRNVDSAKVSMPGQIINCTTNKLATNDLPLPDDVL 250
            |.|||:|||.|||.|:|:.|||||.::|||:||::||:|||.||:..|...........:.:.::
Human   191 LNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGII 255

  Fly   251 EEAHHNSMFPNPFSISEDEESSPPGDDAADGSSESAAAGADFKKPNTTKS-----TTEAAKNYTW 310
            ||.            .||||.|   :..:....|....|.    |:.|::     .|:....|||
Human   256 EEE------------EEDEEGS---ESISKRKKEDDMEGL----PSETQNLLLFLQTKKDHPYTW 301

  Fly   311 RIDLSKSEKYWVGWFSGLSDKFLNLRLPKQLLLASIDGLDRTLTVGQMQGRFQMQVLARCGHAVH 375
            ||:|:|:||||.|||.|||:.||:..:||.||||.:|.||:.||:|||||:||||||.:||||||
Human   302 RIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVH 366

  Fly   376 EDRPHEVAEVISGYLIRNRFAEAASEFRCHMPSC 409
            ||.|.:|||.::.:|||:||||....|:|..|.|
Human   367 EDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5068	NP_001261609.1	MhpC	70..>204	CDD:223669	75/133 (56%)
		Abhydrolase_5	73..>161	CDD:289465	45/87 (52%)
PPME1	NP_001258522.1	MhpC	66..384	CDD:223669	164/339 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142989
Domainoid	1	1.000	304	1.000	Domainoid score	I1384
eggNOG	1	0.900	-	-		E2759_KOG2564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6099
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2147
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53813
OrthoDB	1	1.010	-	-		D473604at33208
OrthoFinder	1	1.000	-	-		FOG0004995
OrthoInspector	1	1.000	-	-		oto89638
orthoMCL	1	0.900	-	-		OOG6_102589
Panther	1	1.100	-	-	LDO	PTHR14189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R974
SonicParanoid	1	1.000	-	-		X3528
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800