DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5068 and ppme1

DIOPT Version :9

Sequence 1:	NP_001261609.1	Gene:	CG5068 / 39032	FlyBaseID:	FBgn0035951	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_956231.1	Gene:	ppme1 / 335124	ZFINID:	ZDB-GENE-030131-7064	Length:	377	Species:	Danio rerio

Alignment Length:	404	Identity:	192/404 - (47%)
Similarity:	256/404 - (63%)	Gaps:	37/404 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQRTMLKGKLPPTIPGGRIGRADSFKKSRIRDYKPGMWNEFFAEKEDVTVDEQR-----TFRIYR 63
            |...:|..|  |.:.|.:.|........|.||:.|..|:.:|...|||.|:.:.     |||||.
Zfish     5 LHLNLLASK--PPMAGLQSGSKIRMGPGRKRDFSPLPWSHYFETIEDVEVEVENDNSKDTFRIYS 67

  Fly    64 TKQPEKPGPVLLLLHGGGYSALTWAHFCSEVTSMIHCQCLCIDMRGHGDSKVDDEDDLSADTLAK 128
            :   ...|||||||||||:|||:||.|.|.:.|.|.|:.:.:|:||||||||.:.|||||:|:||
Zfish    68 S---GSHGPVLLLLHGGGHSALSWAVFTSVICSRITCRVVAMDLRGHGDSKVKNPDDLSAETMAK 129

  Fly   129 DIGDLILKLYPEEVPQLFVVGHSMGGAIAVHFAHMALVPNLIGITVIDVVEGTAMEALASMQSFL 193
            |||.::..||.|..|.:.::|||||||||||.|....||:|:|:.||||||||||:||.|||:||
Zfish   130 DIGKVVEALYGENPPPIMIIGHSMGGAIAVHTAAANHVPSLLGLCVIDVVEGTAMDALNSMQNFL 194

  Fly   194 RSRPKYFQSIPNAIEWCIRSGQVRNVDSAKVSMPGQIINCTTNKLATNDLPLPDDVLEEAHHNSM 258
            |||||.|:|:.|||||.::|||:|||:||:|||.||:..|        :.||....:.::....:
Zfish   195 RSRPKTFKSVENAIEWSVKSGQIRNVESARVSMVGQVKKC--------EEPLSSPGVSKSISEGI 251

  Fly   259 FPNPFSISEDEESSPPGDDAADGSSESAAAGADFKKPNTTKSTTEAAKNYTWRIDLSKSEKYWVG 323
                  |.|:||....|:             ::.|:........:....|||||:|||:||||.|
Zfish   252 ------IEEEEEDEEGGE-------------SNHKRKKEDDQEIKKESLYTWRIELSKTEKYWEG 297

  Fly   324 WFSGLSDKFLNLRLPKQLLLASIDGLDRTLTVGQMQGRFQMQVLARCGHAVHEDRPHEVAEVISG 388
            ||.|||..||:..:||.||||.||.||:.||:|||||:||||||.:||||||||.|.:||:.::.
Zfish   298 WFKGLSSLFLSCSVPKLLLLAGIDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPEKVADALAT 362

  Fly   389 YLIRNRFAEAASEF 402
            :::|:||.|....|
Zfish   363 FMVRHRFTELKEGF 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5068	NP_001261609.1	MhpC	70..>204	CDD:223669	85/133 (64%)
CG5068	NP_001261609.1	Abhydrolase_5	73..>161	CDD:289465	54/87 (62%)
ppme1	NP_956231.1	MhpC	69..367	CDD:223669	166/324 (51%)
		Abhydrolase_5	74..>165	CDD:289465	55/90 (61%)
		SH3	265..>303	CDD:302595	17/37 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575839
Domainoid	1	1.000	314	1.000	Domainoid score	I1267
eggNOG	1	0.900	-	-		E2759_KOG2564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6099
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2231
OMA	1	1.010	-	-		QHG53813
OrthoDB	1	1.010	-	-		D473604at33208
OrthoFinder	1	1.000	-	-		FOG0004995
OrthoInspector	1	1.000	-	-		oto40631
orthoMCL	1	0.900	-	-		OOG6_102589
Panther	1	1.100	-	-	LDO	PTHR14189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R974
SonicParanoid	1	1.000	-	-		X3528
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800