DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5068 and SPBP4H10.17c

DIOPT Version :9

Sequence 1:	NP_001261609.1	Gene:	CG5068 / 39032	FlyBaseID:	FBgn0035951	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_596191.1	Gene:	SPBP4H10.17c / 2541371	PomBaseID:	SPBP4H10.17c	Length:	341	Species:	Schizosaccharomyces pombe

Alignment Length:	364	Identity:	116/364 - (31%)
Similarity:	182/364 - (50%)	Gaps:	84/364 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 WNEFFAEKEDVTVDEQR-----TFRIYRTKQPEKPGPVLLLLHGGGYSALTWAHFCSEVTSMIHC 100
            |..:|.||  :|:..:.     |...|.| .|:..|.:|:|.||.|.||:::|....|:.|....
pombe    37 WRNYFDEK--LTIPGESGALNGTINGYLT-LPQPDGCLLVLQHGAGSSAMSFAPVTQELLSNSDN 98

  Fly   101 QC--LCIDMRGHGDSKVDDEDDLSADTLAKDIG---DLILKLYPEEVPQLFVVGHSMGGAIAVHF 160
            :.  |.:|:|.||::.::.|.|:|.:||:||..   ..:.::: |...::.:||||:||||..:.
pombe    99 KVGFLALDLRAHGETTLEPESDMSLETLSKDFTHAVSYVQRMF-ELDEKIILVGHSLGGAICAYC 162

  Fly   161 AHMALVPNLIGITVIDVVEGTAMEALASMQSFLRSRPKYFQSIPNAIEWCIRSGQVRNVDSAKVS 225
            |....:||..|:.|||||||||||||..|:::|.:||..|:||.:||.|.|::...||..||.::
pombe   163 AFQKTIPNTSGLVVIDVVEGTAMEALGFMKTYLSNRPTSFKSIDDAISWHIKTLVTRNRLSACIT 227

  Fly   226 MPGQIINCTTNKLATNDLPLPDDVLEEAHHNSMFPNPFSISEDEESSPPGDDAADGSSESAAAGA 290
            :|..::                                             ...||:
pombe   228 VPSLLV---------------------------------------------QQEDGT-------- 239

  Fly   291 DFKKPNTTKSTTEAAKNYTWRIDLSKSEKYWVGWFSGLSDKFLNLRLPKQLLLASIDGLDRTLTV 355
                             :.||.||.|:..||:.||.|||||||.....:.|::|..|.||:|||:
pombe   240 -----------------FVWRTDLYKTSPYWMDWFKGLSDKFLRAPYGRMLIVAGTDRLDKTLTI 287

  Fly   356 GQMQGRFQMQVLARCGHAVHEDRPHEVAEVISGYLIRNR 394
            |||||::|:::|...||.||||.|.:::.::..:..||:
pombe   288 GQMQGKYQLEILPETGHFVHEDVPAKISSLLLNFWHRNQ 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5068	NP_001261609.1	MhpC	70..>204	CDD:223669	55/138 (40%)
CG5068	NP_001261609.1	Abhydrolase_5	73..>161	CDD:289465	31/92 (34%)
SPBP4H10.17c	NP_596191.1	MhpC	67..321	CDD:223669	105/324 (32%)
SPBP4H10.17c	NP_596191.1	Abhydrolase_5	71..>178	CDD:289465	36/107 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	207	1.000	Domainoid score	I623
eggNOG	1	0.900	-	-		E2759_KOG2564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6099
Inparanoid	1	1.050	218	1.000	Inparanoid score	I913
OMA	1	1.010	-	-		QHG53813
OrthoFinder	1	1.000	-	-		FOG0004995
OrthoInspector	1	1.000	-	-		oto101093
orthoMCL	1	0.900	-	-		OOG6_102589
Panther	1	1.100	-	-	LDO	PTHR14189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R974
SonicParanoid	1	1.000	-	-		X3528
TreeFam	1	0.960	-	-
	14	13.860