DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5068 and EPHX2

DIOPT Version :9

Sequence 1:	NP_001261609.1	Gene:	CG5068 / 39032	FlyBaseID:	FBgn0035951	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001970.2	Gene:	EPHX2 / 2053	HGNCID:	3402	Length:	555	Species:	Homo sapiens

Alignment Length:	363	Identity:	70/363 - (19%)
Similarity:	126/363 - (34%)	Gaps:	121/363 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 GPVLLLLHGGGYSALTWAHFCSEVTSMIHC--QCLCIDMRGHGDSKVDDE-DDLSADTLAKDIGD 132
            ||.:.|.||...|..:|.:   ::.::...  :.|.:||:|:|:|....| ::...:.|.|::..
Human   258 GPAVCLCHGFPESWYSWRY---QIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVT 319

  Fly   133 LILKLYPEEVPQLFVVGHSMGGAIAVHFAHMALVPNLIGITVIDVVEGTAMEALASMQS-FLRSR 196
            .:.||   .:.|...:||..||.:..:.|  ...|..:             .|:||:.: |:.:.
Human   320 FLDKL---GLSQAVFIGHDWGGMLVWYMA--LFYPERV-------------RAVASLNTPFIPAN 366

  Fly   197 PK-----------------YFQSIPNAIEWCIRSGQVRNVDSAKVSMPGQIINCTTNKLATNDLP 244
            |.                 |||.                        ||         :|..:|
Human   367 PNMSPLESIKANPVFDYQLYFQE------------------------PG---------VAEAEL- 397

  Fly   245 LPDDVLEEAHHNSMFPNPFSISEDEESSPPGDDAADGSSESAAAGADF----KKPNTTKSTTEAA 305
                   |.:.:..|.:.|..|         |::.....:...||..|    ::|:.::..||..
Human   398 -------EQNLSRTFKSLFRAS---------DESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEE 446

  Fly   306 --------KNYTWRIDLS---KSEKYWVGWFSGLSDKFLNLRLPKQLLLASIDGLDRTLTVGQMQ 359
                    |...:|..|:   ..|:.|......|..|.|   :|..::.|..|    .:.|.||.
Human   447 IQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKIL---IPALMVTAEKD----FVLVPQMS 504

  Fly   360 GRFQMQV-------LARCGHAVHEDRPHEVAEVISGYL 390
            ...:..:       :..|||....|:|.||.:::..:|
Human   505 QHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWL 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5068	NP_001261609.1	MhpC	70..>204	CDD:223669	33/153 (22%)
CG5068	NP_001261609.1	Abhydrolase_5	73..>161	CDD:289465	21/90 (23%)
EPHX2	NP_001970.2	Phosphatase	1..224
		HAD_sEH-N_like	3..214	CDD:319790
		Phosphate binding. /evidence=ECO:0000269\|PubMed:15096040	123..124
		Epoxide hydrolase	235..555		70/363 (19%)
		Abhydrolase_1	259..531	CDD:395444	65/349 (19%)
		Microbody targeting signal. /evidence=ECO:0000255	553..555
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910