DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5068 and Ephx2

DIOPT Version :9

Sequence 1:	NP_001261609.1	Gene:	CG5068 / 39032	FlyBaseID:	FBgn0035951	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_031966.2	Gene:	Ephx2 / 13850	MGIID:	99500	Length:	554	Species:	Mus musculus

Alignment Length:	348	Identity:	77/348 - (22%)
Similarity:	133/348 - (38%)	Gaps:	90/348 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 GPVLLLLHGGGYSALTWAHFCSEVTSMIHC--QCLCIDMRGHGDSKVDDE-DDLSADTLAKDIGD 132
            ||.|.|.||...|..:|.:   ::.::...  :.|.|||:|:|||....| ::.:.:.|.|::..
Mouse   256 GPALCLCHGFPESWFSWRY---QIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCKEMVT 317

  Fly   133 LILKLYPEEVPQLFVVGHSMGGAIAVHFAHMALVPNLIGITVIDVVEGTAMEALASMQS-FLRSR 196
            .:.||   .:||...:||...|.:..:.|  ...|..:             .|:||:.: |:...
Mouse   318 FLDKL---GIPQAVFIGHDWAGVMVWNMA--LFYPERV-------------RAVASLNTPFMPPD 364

  Fly   197 P-----KYFQSIPNAIEWCIRSGQVRNVDSAKVSMPGQIINCTTNKLATNDLPLPDDVLEEAHHN 256
            |     |..:|||           |.|. ......||         :|..:|        |.:.:
Mouse   365 PDVSPMKVIRSIP-----------VFNY-QLYFQEPG---------VAEAEL--------EKNMS 400

  Fly   257 SMFPNPFSISEDEESSPPGDDAADGSSESAAAGADF-KKPNTTKSTTEAA--------KNYTWRI 312
            ..|.:.|..|::     .|..|...::|......:. :.||.:|.|||..        |...:|.
Mouse   401 RTFKSFFRASDE-----TGFIAVHKATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRG 460

  Fly   313 DLS---KSEKYWVGWFSGLSDKFLNLRLPKQLLLASIDGLDRTLTVGQMQGRFQMQV-------L 367
            .|:   .:|:.|.....||..|.|   :|..::.|..|.:.|.    :|....:..:       :
Mouse   461 PLNWYRNTERNWKWSCKGLGRKIL---VPALMVTAEKDIVLRP----EMSKNMEKWIPFLKRGHI 518

  Fly   368 ARCGHAVHEDRPHEVAEVISGYL 390
            ..|||....::|.||.:::..:|
Mouse   519 EDCGHWTQIEKPTEVNQILIKWL 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5068	NP_001261609.1	MhpC	70..>204	CDD:223669	35/141 (25%)
CG5068	NP_001261609.1	Abhydrolase_5	73..>161	CDD:289465	24/90 (27%)
Ephx2	NP_031966.2	Phosphatase	1..224
		HAD_sEH-N_like	3..214	CDD:319790
		Phosphate binding. /evidence=ECO:0000250\|UniProtKB:P34913	123..124
		Epoxide hydrolase	233..554		77/348 (22%)
		Abhydrolase_1	257..530	CDD:395444	72/334 (22%)
		Microbody targeting signal. /evidence=ECO:0000255	552..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910