Protein Alignment Srp68 and SRP68

DIOPT Version :10

• Sequence 1: NP_648273.1
• Gene: Srp68 / 39028
• FlyBaseID: FBgn0035947
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_055045.2
• Gene: SRP68 / 6730
• HGNCID: 11302
• Length: 627
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 252/610 - (41%)
• Similarity: 383/610 - (62%)
• Gaps: 39/610 - (6%)

  Fly     4 QEDNPNTGDVQEKTETAPVAEPSKIFTVEILHMIKDAQQQHGLRHGDFQRYRGYCSRRIRRLRKA 68
            :.:.|:.|....|       |.....::|||.:||::|||||||||||||||||||||.|||||.
Human    40 ENERPSAGSKANK-------EFGDSLSLEILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKT 97

  Fly    69 LKYPQGDKRHFKRRDVTIGQLTGKKADERFIHIPLICAERAWAYAMQLKQESNTEPRKRFHLVNK 133
            |.:..|::..|..:.||...||    |.|::.:.|:.|||||:||||||||:||||||||||:::
Human    98 LNFKMGNRHKFTGKKVTEELLT----DNRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSR 158

  Fly   134 LRRACFYALQLQELCNTEAFDARTKLECEAYVAWMHGTLHFELQLWKTAGEHLKRAQVVYENLGK 198
            ||:|..:|.:|:.||.:...||:||||.:||.|::.|.|.||.|.||.|.|...:.:.:||.|..
Human   159 LRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKTIYEKLAS 223

  Fly   199 ALPEDEQELYRAKVNEFTPNLRYCAYNISGGASGGKIDEILELR-----AQGVL-ENLDVLVSQT 257
            |..|::..||..:|.|.:||:|||||||...::   |:|::::|     .:|:| |.|:.|::||
Human   224 AFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSA---INELMQMRLRSGGTEGLLAEKLEALITQT 285

  Fly   258 KTESSEGLQTIDWRGRKVTVRPEKVRLFLLSAQELDKSLAKTTKQDAKIELIERILMDCKDAIQA 322
            :.:.:..:..::||||.|.|:.:|||:|||...:.:.::.:...::.|..|.|.:|.:|:||||.
Human   286 RAKQAATMSEVEWRGRTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDAIQV 350

  Fly   323 VRDEIKQDPKLRS-LTTGQ--TVSGVQYLLAYLSYIRHSRTLQRNLCL---VEQAKLNFYDPNLQ 381
            ||:|:|.|.|.|. :..|:  .||.:|||.:||:||:.|..::||..:   :::|        |.
Human   351 VREELKPDQKQRDYILEGEPGKVSNLQYLHSYLTYIKLSTAIKRNENMAKGLQRA--------LL 407

  Fly   382 SQQNVGDGKR-VRPQDLARLYEIILQNVTEMQQINGLEDDATYQSEVENLAITFKAFRCYYIALT 445
            .||...|.|| .|||||.|||:|||||:.|:.|:.|||:|..:|.|:....:.|||:||::||.:
Human   408 QQQPEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDKAFQKEIGLKTLVFKAYRCFFIAQS 472

  Fly   446 LIDIKKWKEAVALYERASNYATEALKGKSSPEFQLQE--ELKKVVSAIDGCKFSAHAYSVLEDDN 508
            .:.:|||.||:.||:|...||.|......:.:..|::  :::::::.:...|.|..|.::|:.::
Human   473 YVLVKKWSEALVLYDRVLKYANEVNSDAGAFKNSLKDLPDVQELITQVRSEKCSLQAAAILDAND 537

  Fly   509 SEESGTTTKSQKTTKPLYERLSLYKEDQSLHTKAPNVFKLTPDMEPIPCKPIFFDLAMTYVELPS 573
            :.::.|::...|..|||.||...:..|.||.||..|:....|..:||||||:|||||:.:|..|.
Human   538 AHQTETSSSQVKDNKPLVERFETFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAFPP 602

  Fly   574 LEGKLESPGKKGASITGFVKGFLGW 598
            ||.|||...|.|  :||::||..|:
Human   603 LEDKLEQKTKSG--LTGYIKGIFGF 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srp68	NP_648273.1	SRP68	46..569	CDD:465323	224/537 (42%)
SRP68	NP_055045.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		3/19 (16%)
		RNA-binding. /evidence=ECO:0000269|PubMed:16672232	52..252		108/210 (51%)
		SRP68	75..598	CDD:465323	224/537 (42%)
		Required for interaction with SRP72. /evidence=ECO:0000269|PubMed:16672232, ECO:0000269|PubMed:28369529	588..610		13/21 (62%)