DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srp68 and srp68

DIOPT Version :9

Sequence 1:	NP_648273.1	Gene:	Srp68 / 39028	FlyBaseID:	FBgn0035947	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001342750.1	Gene:	srp68 / 2539391	PomBaseID:	SPCC1682.05c	Length:	597	Species:	Schizosaccharomyces pombe

Alignment Length:	614	Identity:	147/614 - (23%)
Similarity:	257/614 - (41%)	Gaps:	127/614 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ILHMIKDAQQQHGLRHGDFQRYRGYCSRRIRRLRKALKYPQGDKRHFKRRDVTIGQLTGKKADER 97
            |..::.:|:..|.....:   |..|.|.||..|||:|        |..:|    |.......|:|
pombe    61 IFPLLLEARSDHFYEGNE---YIKYLSHRIHGLRKSL--------HITQR----GGKPKSSVDKR 110

  Fly    98 FIHIPLICAERAWAYAMQLKQESNTEPRKRFHLVNKLRRACFYALQLQELCNTEAFDARTK---L 159
            :..|.|..|:||:...:.|:..      :|.|.:.:|:||..:..:|...  |.|||....   |
pombe   111 YAEILLFNADRAFQQFVFLRSS------QRRHALRRLKRADQFGKELVSF--TNAFDCNDHIFYL 167

  Fly   160 ECEAYVAWMHGTLHFELQLWK---TAGEHLKRAQVVYENLGKALPEDEQELYRAKVNEFTPNLRY 221
            |..|:..::.|||::|.:.|:   :|....:.:.:|.:|....|.|.|:.:.....|:...||||
pombe   168 EAIAFAKYIEGTLNYEKRDWEGSLSAFSISRLSFLVLQNKIDTLAEHEKSVLGELQNQIDSNLRY 232

  Fly   222 CAYNISGGASGGKIDEILEL----RAQGVLE---NLDVLVSQTKTESSEGLQT---IDWRGRKVT 276
            .|.. :|..:..|..:||.|    :.:.|::   ::|..:.|...:..:.|||   |:||.::|.
pombe   233 VAQR-TGLQNQTKSLDILMLSSIPKDEEVIQHVNSVDSEILQMTGDEQDSLQTITVIEWRDQRVK 296

  Fly   277 VRPEKVRLFLLSAQELDKSLAK-TTKQD------AKIELIERILMDCKDAIQAVRDEIKQDPKLR 334
            :....|.|.|.:..::..|... .:|:|      |:.|.|.:.::|        ...::.:.|.:
pombe   297 IEHPDVVLALYAIHDVKNSPGTIDSKRDRLLAAWARAEEITKSVLD--------NTGLEDEQKFQ 353

  Fly   335 SLTTGQTVSGVQYLLAYLSYIRHSRTLQRNLCLVEQAKLNFYDPNLQSQQNVGDGKRVRPQDLAR 399
            :|:...|         ||:|......:||:|.:...::|......|:|:|:
pombe   354 TLSICYT---------YLAYNVVLLRIQRDLAVENDSELVASQAQLRSRQS-------------- 395

  Fly   400 LYEIILQNVTEMQQINGLEDDATYQSEVENLAITFKAFRCYYIALTLIDIKKWKE---AVALYER 461
            ||:.|::|:...:::.|:..|....:::|......|:.||..||    |..:.::   ::|:..|
pombe   396 LYDSIIKNIEIAKELPGIARDTGMTAQLEAQISLAKSKRCQAIA----DAYQAQDKLASLAMCVR 456

  Fly   462 ASNY---ATEALKGKSS----------PEFQLQE-ELKKVVSAIDGCKFSAHAYSVLEDDNSEES 512
            |::|   ..:.|:....          ||.:..| ||||               .:|...:....
pombe   457 AASYLQQVNDILRNFEEKPHLIAFDIIPELKKDEKELKK---------------KILLLQSLASM 506

  Fly   513 GTTTKSQKTTKPLYERLSLYKEDQSLHTKAPNVFKLTPDMEPIPCKPIFFDLAMTYV-ELPSLEG 576
            |...:..|... |.|.|..|   |:|....|:......|:..||.||:|||||:||: :..|.:.
pombe   507 GNINQPPKNLS-LVETLDSY---QTLAELEPSWNLTDADIRAIPAKPLFFDLAITYLGQQTSFDK 567

  Fly   577 KLESPGKKGASIT--------GFVKGFLG 597
            |...|.|...|::        ||....||
pombe   568 KKAQPEKPVTSVSKEPKQKNKGFFSSLLG 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srp68	NP_648273.1	SRP68	46..568	CDD:293574	133/561 (24%)
srp68	NP_001342750.1	Pox_vIL-18BP	11..>97	CDD:305108	13/46 (28%)
srp68	NP_001342750.1	SRP68-RBD	77..558	CDD:328892	133/558 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	89	1.000	Domainoid score	I2102
eggNOG	1	0.900	-	-		E1_KOG2460
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I1722
OMA	1	1.010	-	-		QHG54870
OrthoFinder	1	1.000	-	-		FOG0005221
OrthoInspector	1	1.000	-	-		oto101807
orthoMCL	1	0.900	-	-		OOG6_102026
Panther	1	1.100	-	-	LDO	PTHR12860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1392
SonicParanoid	1	1.000	-	-		X3732
TreeFam	0	0.000	Not matched by this tool.
	12	11.900