Protein Alignment Srp68 and Srp68

DIOPT Version :10

• Sequence 1: NP_648273.1
• Gene: Srp68 / 39028
• FlyBaseID: FBgn0035947
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_666144.3
• Gene: Srp68 / 217337
• MGIID: 1917447
• Length: 625
• Species: Mus musculus
• Alignment Length: 607
• Identity: 255/607 - (42%)
• Similarity: 383/607 - (63%)
• Gaps: 34/607 - (5%)

  Fly     4 QEDNPNTGDVQEKTETAPVAEPSKIFTVEILHMIKDAQQQHGLRHGDFQRYRGYCSRRIRRLRKA 68
            :.:.|:.|....|       |.....::|||.:||::|||||||||||||||||||||.|||||.
Mouse    39 ENERPSAGSKANK-------EFGDSLSLEILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKT 96

  Fly    69 LKYPQGDKRHFKRRDVTIGQLTGKKADERFIHIPLICAERAWAYAMQLKQESNTEPRKRFHLVNK 133
            |.:..|::..|..:.||...||    |.|::.:.|:.|||||:||||||||:||||||||||:::
Mouse    97 LNFKMGNRHKFTGKKVTEELLT----DNRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSR 157

  Fly   134 LRRACFYALQLQELCNTEAFDARTKLECEAYVAWMHGTLHFELQLWKTAGEHLKRAQVVYENLGK 198
            ||:|..:|.:|:.||.:...||:||||.:||.|::.|.|.||.|.||:|.|...:.:.:||.|..
Mouse   158 LRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKSAIEAFNKCKTIYEKLAS 222

  Fly   199 ALPEDEQELYRAKVNEFTPNLRYCAYNISGGASGGKIDEILELR-----AQGVL-ENLDVLVSQT 257
            |..|::..||..:|.|.:||:|||||||...::   |:|::::|     .:|:| |.|:.|::||
Mouse   223 AFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSA---INELMQMRLRSGGTEGLLAEKLEALITQT 284

  Fly   258 KTESSEGLQTIDWRGRKVTVRPEKVRLFLLSAQELDKSLAKTTKQDAKIELIERILMDCKDAIQA 322
            :.:.:..:..::||||.|.|:.:|||:|||...:.:.::.:...::.|..|.|.:|.:|:||:||
Mouse   285 RAKQAATMSEVEWRGRTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDALQA 349

  Fly   323 VRDEIKQDPKLRSLT-TGQT--VSGVQYLLAYLSYIRHSRTLQRNLCLVEQAKLNFYDPNLQSQQ 384
            ||:|:|.|.|.|... .|::  ||.:|||.:||:||:.|..::||    |......:...|| ||
Mouse   350 VREELKPDQKQRDYALDGESGKVSNLQYLHSYLTYIKLSTAIRRN----ENMAKGLHRALLQ-QQ 409

  Fly   385 NVGDGKR-VRPQDLARLYEIILQNVTEMQQINGLEDDATYQSEVENLAITFKAFRCYYIALTLID 448
            ...|.|| .|||||.|||:|||||:.|:.|:.|||:|.|:|.|:....:.|||:||::||.:.:.
Mouse   410 PEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDRTFQKEISLKTLVFKAYRCFFIAQSYVL 474

  Fly   449 IKKWKEAVALYERASNYATEALK--GKSSPEFQLQEELKKVVSAIDGCKFSAHAYSVLEDDNSEE 511
            :|||.||:.||:|...||.|...  |.|....:...:::::::.:...|.|..|.::|:.::|.:
Mouse   475 VKKWSEALVLYDRVLKYANEVSSHGGASKNSLKDLPDVQELITQVRSEKCSLQAAAILDANDSHQ 539

  Fly   512 SGTTTKSQKTTKPLYERLSLYKEDQSLHTKAPNVFKLTPDMEPIPCKPIFFDLAMTYVELPSLEG 576
            :.|:::.:..| ||.||...:..|.||.||..|:....|..:||||||:|||||:.:|..|.||.
Mouse   540 TDTSSQVKDNT-PLVERFESFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAFPPLED 603

  Fly   577 KLESPGKKGASITGFVKGFLGW 598
            |||...|.|  :||::||..|:
Mouse   604 KLEQKTKSG--LTGYIKGIFGF 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srp68	NP_648273.1	SRP68	46..569	CDD:465323	227/534 (43%)
Srp68	NP_666144.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		2/12 (17%)
		RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9UHB9	51..251		100/199 (50%)
		SRP68	74..596	CDD:465323	227/533 (43%)
		Required for interaction with SRP72. /evidence=ECO:0000250|UniProtKB:Q9UHB9	586..608		12/21 (57%)