DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srp68 and Srp68

DIOPT Version :9

Sequence 1:	NP_648273.1	Gene:	Srp68 / 39028	FlyBaseID:	FBgn0035947	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_666144.3	Gene:	Srp68 / 217337	MGIID:	1917447	Length:	625	Species:	Mus musculus

Alignment Length:	607	Identity:	255/607 - (42%)
Similarity:	383/607 - (63%)	Gaps:	34/607 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QEDNPNTGDVQEKTETAPVAEPSKIFTVEILHMIKDAQQQHGLRHGDFQRYRGYCSRRIRRLRKA 68
            :.:.|:.|....|       |.....::|||.:||::|||||||||||||||||||||.|||||.
Mouse    39 ENERPSAGSKANK-------EFGDSLSLEILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKT 96

  Fly    69 LKYPQGDKRHFKRRDVTIGQLTGKKADERFIHIPLICAERAWAYAMQLKQESNTEPRKRFHLVNK 133
            |.:..|::..|..:.||...||    |.|::.:.|:.|||||:||||||||:||||||||||:::
Mouse    97 LNFKMGNRHKFTGKKVTEELLT----DNRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSR 157

  Fly   134 LRRACFYALQLQELCNTEAFDARTKLECEAYVAWMHGTLHFELQLWKTAGEHLKRAQVVYENLGK 198
            ||:|..:|.:|:.||.:...||:||||.:||.|::.|.|.||.|.||:|.|...:.:.:||.|..
Mouse   158 LRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKSAIEAFNKCKTIYEKLAS 222

  Fly   199 ALPEDEQELYRAKVNEFTPNLRYCAYNISGGASGGKIDEILELR-----AQGVL-ENLDVLVSQT 257
            |..|::..||..:|.|.:||:|||||||...::   |:|::::|     .:|:| |.|:.|::||
Mouse   223 AFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSA---INELMQMRLRSGGTEGLLAEKLEALITQT 284

  Fly   258 KTESSEGLQTIDWRGRKVTVRPEKVRLFLLSAQELDKSLAKTTKQDAKIELIERILMDCKDAIQA 322
            :.:.:..:..::||||.|.|:.:|||:|||...:.:.::.:...::.|..|.|.:|.:|:||:||
Mouse   285 RAKQAATMSEVEWRGRTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDALQA 349

  Fly   323 VRDEIKQDPKLRSLT-TGQT--VSGVQYLLAYLSYIRHSRTLQRNLCLVEQAKLNFYDPNLQSQQ 384
            ||:|:|.|.|.|... .|::  ||.:|||.:||:||:.|..::||    |......:...|| ||
Mouse   350 VREELKPDQKQRDYALDGESGKVSNLQYLHSYLTYIKLSTAIRRN----ENMAKGLHRALLQ-QQ 409

  Fly   385 NVGDGKR-VRPQDLARLYEIILQNVTEMQQINGLEDDATYQSEVENLAITFKAFRCYYIALTLID 448
            ...|.|| .|||||.|||:|||||:.|:.|:.|||:|.|:|.|:....:.|||:||::||.:.:.
Mouse   410 PEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDRTFQKEISLKTLVFKAYRCFFIAQSYVL 474

  Fly   449 IKKWKEAVALYERASNYATEALK--GKSSPEFQLQEELKKVVSAIDGCKFSAHAYSVLEDDNSEE 511
            :|||.||:.||:|...||.|...  |.|....:...:::::::.:...|.|..|.::|:.::|.:
Mouse   475 VKKWSEALVLYDRVLKYANEVSSHGGASKNSLKDLPDVQELITQVRSEKCSLQAAAILDANDSHQ 539

  Fly   512 SGTTTKSQKTTKPLYERLSLYKEDQSLHTKAPNVFKLTPDMEPIPCKPIFFDLAMTYVELPSLEG 576
            :.|:::.:..| ||.||...:..|.||.||..|:....|..:||||||:|||||:.:|..|.||.
Mouse   540 TDTSSQVKDNT-PLVERFESFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAFPPLED 603

  Fly   577 KLESPGKKGASITGFVKGFLGW 598
            |||...|.|  :||::||..|:
Mouse   604 KLEQKTKSG--LTGYIKGIFGF 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srp68	NP_648273.1	SRP68	46..568	CDD:293574	227/533 (43%)
Srp68	NP_666144.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		2/12 (17%)
Srp68	NP_666144.3	SRP68	74..595	CDD:293574	226/532 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845712
Domainoid	1	1.000	421	1.000	Domainoid score	I635
eggNOG	1	0.900	-	-		E1_KOG2460
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7056
Inparanoid	1	1.050	467	1.000	Inparanoid score	I1522
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54870
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005221
OrthoInspector	1	1.000	-	-		oto94651
orthoMCL	1	0.900	-	-		OOG6_102026
Panther	1	1.100	-	-	LDO	PTHR12860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1392
SonicParanoid	1	1.000	-	-		X3732
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790