Protein Alignment Srp68 and srpa-68

DIOPT Version :10

• Sequence 1: NP_648273.1
• Gene: Srp68 / 39028
• FlyBaseID: FBgn0035947
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_506083.1
• Gene: srpa-68 / 179686
• WormBaseID: WBGene00010097
• Length: 622
• Species: Caenorhabditis elegans
• Alignment Length: 643
• Identity: 200/643 - (31%)
• Similarity: 326/643 - (50%)
• Gaps: 77/643 - (11%)

  Fly    10 TGDVQEKTETAPVAEPSKIFTVEILHMIKDAQQQHGLRHGDFQRYRGYCSRRIRRLRKALKYPQG 74
            |.||:.|:||   .|.....||.||.::|||||||||||||:.|||.||:.::.|:|||||:...
 Worm     2 TNDVEMKSET---EELPPFPTVHILQVVKDAQQQHGLRHGDYARYRKYCAAKLERMRKALKFTNS 63

  Fly    75 DKRHFKRRDVTIGQLTGKKA--DERFIHIPLICAERAWAYAM--QLKQESNTE-PRKRFHLVNKL 134
            .....||:...:.:....::  :.:|::..:..:||.:|.||  ::..|.|.| .||:|.::|.|
 Worm    64 HNCQKKRKAKFVKKWLSVESVQNVQFLNFGIFESERRYAEAMIDKITLEDNPEKSRKKFSMINSL 128

  Fly   135 RRACFYALQLQELC-NTEAFDARTKLECEAYVAWMHGTLHFELQLWKTAGEHLKRAQVVYENLGK 198
            |:|..:|..|:::. .:|.|||.||||.:||.|||.|...||.:.|:.|.|.||.|:.|||.|.:
 Worm   129 RKAVLHATNLEKIVQESERFDAPTKLEAQAYAAWMRGMCSFESRNWQKASESLKLAKTVYEKLAE 193

  Fly   199 ALPEDE-QELYRAKVNEFTPNLRYCAYNI--SGGASGGKIDEILELRAQ---GVLENLDVLVSQT 257
            |..... ..:::.:..|..|.||.|.:||  |.||. |.:.|::|||.|   |...::|.|:|:.
 Worm   194 ATNNTTLSSIFKGRCREIQPQLRLCEFNIAESPGAV-GTMTELMELRMQMGEGGDSSVDKLISEM 257

  Fly   258 K-TESSEGLQTIDWRGRKVTVRPEKVRLFLLSAQELDKSLAKTTKQDAKIELIERILMDCKDAIQ 321
            : :.:|..:.||:|.|.|.||..||.:..:...::.:..||:......|:.|.|:...|.:|||.
 Worm   258 RASATSAEVVTIEWGGAKSTVDDEKAKQVVQEWKQTEVELAQCQTPKEKMALFEKATADTRDAID 322

  Fly   322 AVRDEIKQDPKLRSLTTGQTVSGVQYLLAYLSYIRHSRTLQRNLCLVEQAKLNFYDPNLQSQQNV 386
            .:.|.|::.....:.||     .:|.:.|||.:::.:.|..|.|.:::..|
 Worm   323 RISDIIRRKSSENADTT-----VLQSIKAYLEFLKMNGTASRYLAIIDNTK-------------- 368

  Fly   387 GDGKRVRPQDLARLYEIILQNVTEMQQINGLEDDATYQSEVENLAITFKAFRCYYIALTLIDIKK 451
             ..|:.:||||.|||:.:::...|:.:|.|.:.|.......|.....::||||:|:|.:...:.|
 Worm   369 -SEKKSKPQDLLRLYDSVIEIYKEVAEIPGADHDKNLIQAFEVKVEYYRAFRCFYMASSYSALHK 432

  Fly   452 WKEAVALYERASNYATEA---LKGKSSPEF---QLQEELKKVVSAIDGCKFSAHAYSVLEDDNSE 510
            :.||.||::|..:...:|   ||...|..|   :.|..|.::.|.::..|.:..|..:.......
 Worm   433 YSEAAALFDRTVSRVQDAEGKLKKLKSSSFITNETQSSLNELRSEVESAKVTVRAARLASAAGDV 497

  Fly   511 ESGTTTKSQKTTKPLYERLSLYKE---DQSLHTKAP-NVFKLTPDMEPIPCKPIFFDLAMTYVEL 571
            ::.:........:||.|.::.:::   ..||..|.. .|..|.|...|:|.||||||||..::.:
 Worm   498 KTDSELAKIIDKRPLLETVNEWRQWDVRNSLKDKKTIPVASLPPAFIPMPNKPIFFDLANFHLTM 562

  Fly   572 PSLEGKLE--------SPGK--KGAS------------------ITGFVKGFLG--WG 599
            |:::.:||        :|.|  ||:|                  :||.:.|:..  ||
 Worm   563 PNVDDRLEKLQKDRDATPKKAAKGSSAAAASSKTSNQEEEEQQGLTGMLSGWKKSFWG 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srp68	NP_648273.1	SRP68	46..569	CDD:465323	168/545 (31%)
srpa-68	NP_506083.1	SRP68-RBD	35..556	CDD:473954	166/541 (31%)