DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pix and abce1

DIOPT Version :9

Sequence 1:	NP_648272.1	Gene:	pix / 39027	FlyBaseID:	FBgn0086706	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_998216.2	Gene:	abce1 / 406324	ZFINID:	ZDB-GENE-040426-1995	Length:	599	Species:	Danio rerio

Alignment Length:	597	Identity:	463/597 - (77%)
Similarity:	528/597 - (88%)	Gaps:	0/597 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DKQTRIAIVSDDKCKPKRCRQECKKTCPVVRMGKLCIEVTPTSKIASLSEELCIGCGICVKKCPF 75
            ||.||||||:.||||||:|||||||:|||||||||||||:|.|||..:||.||||||||:|||||
Zfish     3 DKNTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVSPQSKIVWISESLCIGCGICIKKCPF 67

  Fly    76 EAITIINLPSNLEKHTTHRYSKNSFKLHRLPIPRPGEVLGLVGQNGIGKSTALKILAGKQKPNLG 140
            .|::|:||||||||.|||||..|||||||||||||||||||||.|||||||||||||||||||||
Zfish    68 GALSIVNLPSNLEKETTHRYCANSFKLHRLPIPRPGEVLGLVGTNGIGKSTALKILAGKQKPNLG 132

  Fly   141 KYANPPDWTEILSYFRGSELQNYFTKILEDNLKALVKPQYVDQIPKAVRGAVGDLLDKKDERELQ 205
            ::..||||.|||:|||||||||||||||||:|||:|||||||||||.|:|:||.:|.:||:.:.:
Zfish   133 RFDAPPDWQEILAYFRGSELQNYFTKILEDDLKAIVKPQYVDQIPKTVKGSVGAILSRKDDTKTE 197

  Fly   206 TKICEMLDLSHIRDREIAQLSGGELQRFAIAMVCIQNADIFMFDEPSSYLDVKQRLNAALTIRSL 270
            ..:||.|||.|:|||.:..||||||||||.|:||||.|||||||||||||||||||.||:|||||
Zfish   198 ELVCEQLDLLHLRDRNVEDLSGGELQRFACAVVCIQRADIFMFDEPSSYLDVKQRLRAAITIRSL 262

  Fly   271 LHPTKFIIVVEHDLSVLDYLSDFICCLYGVPGCYGVVTMPFSVREGINIFLDGFVPTENMRFRTE 335
            :.|.::|||||||||||||||||||||||||..||||||||||||||||||||:|||||:|||..
Zfish   263 ISPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPFSVREGINIFLDGYVPTENLRFRET 327

  Fly   336 SLTFKVSESATEEEIKRMNHYVYPAMVKTLGKFELTVEKGHFSDSEILVLLGENGTGKTTFIRML 400
            ||.|||:|:|.|||:|::..|.||.|.|::|:|.||:.:|.|:||||:|:|||||||||||||||
Zfish   328 SLVFKVAETAAEEEVKKLCRYQYPNMKKSMGEFTLTITEGEFTDSEIMVMLGENGTGKTTFIRML 392

  Fly   401 AGNLQPDGEVELPMLNISYKPQKISPKFQNHVRHLLHDKIRDAYVHPQFIADVMKPMKIEEIMDQ 465
            ||.|:|||..::|:||:|||||||||||:..||.||||||||||.||||:.||||||:||.|:||
Zfish   393 AGGLKPDGGGDVPILNVSYKPQKISPKFKGSVRALLHDKIRDAYTHPQFVTDVMKPMQIESIIDQ 457

  Fly   466 EVQNLSGGELQRVALVLCLGKPADVYLIDEPSAYLDSEQRLVAAKVIKRYILHAKKTGFVVEHDF 530
            :||||||||||||||.|||||||||||||||||||||||||:||:||||:|||||||.|||||||
Zfish   458 DVQNLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVIKRFILHAKKTAFVVEHDF 522

  Fly   531 IMATYLADRVIVIEGQPSVKTTAFSPQSLLNGMNRFLELLGITFRRDPNNFRPRINKNNSVKDTE 595
            ||||||||||||.:|.||..|.|.:||:||.|||:||..|.||||||||||||||||.||:||.|
Zfish   523 IMATYLADRVIVFDGIPSRTTNANAPQTLLAGMNKFLAQLEITFRRDPNNFRPRINKLNSIKDVE 587

  Fly   596 QKRSGQFFFLED 607
            ||:||.:|||:|
Zfish   588 QKKSGNYFFLDD 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pix	NP_648272.1	Rli1	12..605	CDD:224166	459/592 (78%)
abce1	NP_998216.2	Rli1	4..597	CDD:224166	459/592 (78%)
		RLI	6..37	CDD:281988	26/30 (87%)
		Fer4	48..71	CDD:278466	16/22 (73%)
		ABC_RNaseL_inhibitor_domain1	78..332	CDD:213203	202/253 (80%)
		ABC_RNaseL_inhibitor_domain2	348..592	CDD:213204	187/243 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594738
Domainoid	1	1.000	230	1.000	Domainoid score	I2393
eggNOG	1	0.900	-	-		E1_COG1245
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2205
Inparanoid	1	1.050	958	1.000	Inparanoid score	I318
OMA	1	1.010	-	-		QHG62212
OrthoDB	1	1.010	-	-		D184717at33208
OrthoFinder	1	1.000	-	-		FOG0004228
OrthoInspector	1	1.000	-	-		oto40858
orthoMCL	1	0.900	-	-		OOG6_101314
Panther	1	1.100	-	-	LDO	PTHR19248
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1993
SonicParanoid	1	1.000	-	-		X165
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800