DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pix and rli1

DIOPT Version :9

Sequence 1:	NP_648272.1	Gene:	pix / 39027	FlyBaseID:	FBgn0086706	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_596732.1	Gene:	rli1 / 2539753	PomBaseID:	SPBC14F5.06	Length:	593	Species:	Schizosaccharomyces pombe

Alignment Length:	597	Identity:	386/597 - (64%)
Similarity:	470/597 - (78%)	Gaps:	12/597 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TRIAIVSDDKCKPKRCRQECKKTCPVVRMGKLCIEVTPTSKIASLSEELCIGCGICVKKCPFEAI 78
            |||||||:|||:||:|||||:::|||||.|||||||.||.:||.:||.||||||||||||||.||
pombe     6 TRIAIVSEDKCRPKKCRQECRRSCPVVRTGKLCIEVNPTDRIAFISETLCIGCGICVKKCPFGAI 70

  Fly    79 TIINLPSNLEKHTTHRYSKNSFKLHRLPIPRPGEVLGLVGQNGIGKSTALKILAGKQKPNLGKYA 143
            .|||||:|||...|||||.|||||||||.||||:||||||.||||||||||||:||.|||||:|.
pombe    71 NIINLPTNLESEVTHRYSANSFKLHRLPTPRPGQVLGLVGTNGIGKSTALKILSGKMKPNLGRYD 135

  Fly   144 NPPDWTEILSYFRGSELQNYFTKILEDNLKALVKPQYVDQIPKAVR---GAVGDLLDKKDERELQ 205
            |||||.|::.|||||||||:|||::|||:|||:||||||.||:|::   ..|..|:..:......
pombe   136 NPPDWAEVVKYFRGSELQNFFTKVVEDNIKALIKPQYVDHIPRAIKTGDKTVSGLIKARANNNNF 200

  Fly   206 TKICEMLDLSHIRDREIAQLSGGELQRFAIAMVCIQNADIFMFDEPSSYLDVKQRLNAALTIRSL 270
            .::.:..||.::.:||:..||||||||||||.|..|.||::||||||||||:||||.|...||||
pombe   201 EEVMDHTDLQNLLNREVGHLSGGELQRFAIAAVATQKADVYMFDEPSSYLDIKQRLKAGRVIRSL 265

  Fly   271 LHPTKFIIVVEHDLSVLDYLSDFICCLYGVPGCYGVVTMPFSVREGINIFLDGFVPTENMRFRTE 335
            |..|.::||||||||||||||||:|.|||||..|||||:|:||||||||||||.:||||:|||:|
pombe   266 LATTNYVIVVEHDLSVLDYLSDFVCVLYGVPSMYGVVTLPYSVREGINIFLDGHIPTENLRFRSE 330

  Fly   336 SLTFKVSESATEEEIKRMNHYVYPAMVKTLGKFELTVEKGHFSDSEILVLLGENGTGKTTFIRML 400
            :|||::::::.|....|...|.||..|...|.|:||::.|.|||:||:|||||||||||||.:.:
pombe   331 ALTFRLADASDEITADRTAEYNYPDHVIEQGDFKLTIKSGGFSDAEIIVLLGENGTGKTTFCKWM 395

  Fly   401 AGNLQPDGEVELPMLNISYKPQKISPKFQNHVRHLLHDKIRDAYVHPQFIADVMKPMKIEEIMDQ 465
            |.|..         |.||.|||.|:||||..||.|...|||.|:::.:|.::|.||:.|:.|:||
pombe   396 AKNSD---------LKISMKPQTIAPKFQGTVRMLFLKKIRAAFLNGKFQSEVCKPLSIDNIIDQ 451

  Fly   466 EVQNLSGGELQRVALVLCLGKPADVYLIDEPSAYLDSEQRLVAAKVIKRYILHAKKTGFVVEHDF 530
            ||.|||||||||||:.|.||.|||||||||||||||||||::|:|||:|:|::::||.|:|||||
pombe   452 EVLNLSGGELQRVAICLALGMPADVYLIDEPSAYLDSEQRIIASKVIRRFIVNSRKTAFIVEHDF 516

  Fly   531 IMATYLADRVIVIEGQPSVKTTAFSPQSLLNGMNRFLELLGITFRRDPNNFRPRINKNNSVKDTE 595
            |||||||||||:.|||||.......|||||.|||.||:.|.:|||||||..||||||.:|..|.|
pombe   517 IMATYLADRVILFEGQPSRDARCNPPQSLLTGMNTFLKNLDVTFRRDPNTLRPRINKFDSQMDQE 581

  Fly   596 QKRSGQFFFLED 607
            ||.:|.:||||:
pombe   582 QKNAGNYFFLEN 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pix	NP_648272.1	Rli1	12..605	CDD:224166	383/593 (65%)
rli1	NP_596732.1	Rli1	4..591	CDD:224166	383/593 (65%)
		RLI	6..37	CDD:281988	23/30 (77%)
		Fer4	50..70	CDD:278466	16/19 (84%)
		ABC_RNaseL_inhibitor_domain1	78..335	CDD:213203	173/256 (68%)
		P-loop_NTPase	351..586	CDD:304359	149/243 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	188	1.000	Domainoid score	I740
eggNOG	1	0.900	-	-		E1_COG1245
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2205
Inparanoid	1	1.050	782	1.000	Inparanoid score	I75
OMA	1	1.010	-	-		QHG62212
OrthoFinder	1	1.000	-	-		FOG0004228
OrthoInspector	1	1.000	-	-		oto101737
orthoMCL	1	0.900	-	-		OOG6_101314
Panther	1	1.100	-	-	LDO	PTHR19248
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1993
SonicParanoid	1	1.000	-	-		X165
TreeFam	1	0.960	-	-
	14	13.860