DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5026 and YMR1

DIOPT Version :9

Sequence 1:	NP_001163392.1	Gene:	CG5026 / 39026	FlyBaseID:	FBgn0035945	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_012644.1	Gene:	YMR1 / 853574	SGDID:	S000003871	Length:	688	Species:	Saccharomyces cerevisiae

Alignment Length:	720	Identity:	173/720 - (24%)
Similarity:	255/720 - (35%)	Gaps:	234/720 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEFADLIKTPKLDGVLLHDPSNAGASGATVGTLCITGHHLLLSARQETSQELWLLHKNIDCVEKK 65
            ||:   ||..|:..|:||....     ||.|||.:|.|||:..:.| .|.|.|..:..|..|.|.
Yeast     1 MEY---IKIAKVSNVVLHRRGT-----ATQGTLHLTTHHLIFESPQ-LSTEFWFPYPLIYGVHKN 56

  Fly    66 P------------------------SLSQNIVVGGIITLKC--KDLRIISLEIKCGKEFF----N 100
            |                        .|.|...:...:.:|.  ||..:.||:.  |.:..    .
Yeast    57 PGSTLLSKLTSTNQIQLEGTDSQNYKLYQGKDLWSFVNIKVIGKDYAVFSLDF--GGDLHLQARK 119

  Fly   101 VAASLEALSAIQNTELLYPFFY------RPMYSILEDGYTMFRPELEFAKLISGVGMGGASSPNV 159
            |..|:..|:.:.|...||.|.|      |.:.|  .|.:.::.|..||.:
Yeast   120 VYDSILNLTVLSNITQLYAFIYISNNLERKLPS--PDSWDIYDPIKEFRR--------------- 167

  Fly   160 ANITICMPSTSTSTLTVGAGIPHPLQNGYAIEALACGVGGVGGGALQSPQASCEWRITNVNRDFS 224
                                                       ..|.|...:|.||::.||..:.
Yeast   168 -------------------------------------------QGLDSKDETCPWRLSTVNEHYE 189

  Fly   225 VCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRHE-NGATLMRSSQPL-------SIQGI 281
            .|.||.:.|.||::.:|..:..::.||...|.|||:|.|: ....::||||||       |||..
Yeast   190 FCPTYPSKLFVPRSTSDILLKHASKFRSQKRIPVLTYHHKATDCNILRSSQPLPGLINQRSIQDE 254

  Fly   282 KR--------CRAD---------------EAILNLVLGRSRKG------FIVD-TWGKGKSNTET 316
            |.        |..|               .|:..:.||...:.      |:.| ..|..||
Yeast   255 KLVWESFNSFCNKDIRRTKHVIVDARPRTNALAQMALGGGTENMDNYNFFLADNNMGVDKS---- 315

  Fly   317 DLHYSQWKKVNRSIGNVSSPASILDSFARLIEACNDLGCSTDKWLSRLEN-SGWL---SLVLNSL 377
             |......::...|.|:...::.......:|....||....::.|.|.:. |.||   :|:|.|:
Yeast   316 -LKLPTVTRLFLGIDNIHIVSNTAAYMTEVICQGGDLNLPLEQNLIRSQKFSNWLKLNTLILKSV 379

  Fly   378 NASCVVAQCLDQEGSPVLVHGAKGLDSTLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFA 442
            :   ::.:.:....|.||||.:.|.|.|..|.||::|.|:|..||..|...|:|::|...||.|.
Yeast   380 D---MLLKSIIFNHSNVLVHCSDGWDRTSQVVSLLEICLDPFYRTFEGFMILVEKDWCSFGHRFL 441

  Fly   443 SRHRY--------------------------------------------------------SCYT 451
            .|..:                                                        ..:.
Yeast   442 ERSGHLNSDIRFHDNTMHSNFNDVDTNGDDLDIGVNTQDDYAEDDEGGEDETNLINLSRISKKFN 506

  Fly   452 PNQTRNKTS----GATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCDSERER 512
            .|...||.|    ...|..||||:|||.||.|..|||:.:.|..|..|.:..||||||.:||:|:
Yeast   507 ENFKLNKKSLKFVSPVFQQFLDCVYQLLTQNPDLFEFNERFLRRLVYHLYSCQYGTFLSNSEKEK 571

  Fly   513 NELNVHTRTTSLWSYLNRPDVLQTFLNPLY---------------EPNANVIWPSVAPISLELWS 562
            .:.|:..:|.|:|.|..  ...:.|:||.:               |....|.|.|.....::.|.
Yeast   572 FQQNLPNKTKSVWDYFR--SRRKQFINPNFIQRKRSGMNEHDQNLEEEEKVEWISPDLKKVQWWW 634

  Fly   563 DLYLR 567
            .||.|
Yeast   635 QLYGR 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5026	NP_001163392.1	PH-GRAM_MTMR9	1..106	CDD:275398	35/134 (26%)
CG5026	NP_001163392.1	Myotub-related	117..511	CDD:284109	119/501 (24%)
YMR1	NP_012644.1	PH-like	1..>44	CDD:418428	20/51 (39%)
YMR1	NP_012644.1	Myotub-related	152..570	CDD:399535	114/485 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910