Protein Alignment CG5026 and MTMR8

DIOPT Version :10

• Sequence 1: NP_648271.3
• Gene: CG5026 / 39026
• FlyBaseID: FBgn0035945
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_060147.2
• Gene: MTMR8 / 55613
• HGNCID: 16825
• Length: 704
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 191/651 - (29%)
• Similarity: 295/651 - (45%)
• Gaps: 133/651 - (20%)

  Fly     5 DLIKTPKLDGVLLHD------PSNAGASGATVGTLCITGHHLLL-----SARQETSQELWLLHKN 58
            |.|..||::.|.|.|      |:|        |.|.:|..||:.     :||:||    |:...:
Human     2 DHITVPKVENVKLVDRYVSKKPAN--------GILYLTATHLIYVEASGAARKET----WIALHH 54

  Fly    59 IDCVEKKPSLSQNIVVGGIITLKCKDLRIISLEIKCGKEFFNVAASLEALSAIQNTELLYPFFYR 123
            |..|||.|..|    :|..:||:||:.|:....:........|..||..||.....|.||.|.|.
Human    55 IATVEKLPITS----LGCPLTLRCKNFRVAHFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYN 115

  Fly   124 PMYS--ILEDGYTMFRPELEFAKLISGVGMGGASSPNVANITICMPSTSTSTLTVGAGIPHPLQN 186
            |..|  :.|.|:.:..|..:|.::                                 |||:.
Human   116 PKSSKEMRESGWKLIDPISDFGRM---------------------------------GIPNR--- 144

  Fly   187 GYAIEALACGVGGVGGGALQSPQASCEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFR 251
                                      .|.||:.||::.:|:||...::|||::|...:|.|:.||
Human   145 --------------------------NWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFR 183

  Fly   252 DGGRFPVLSYRH-ENGATLMRSSQPLSIQGI-KRCRADEAILNLVLGRSRKG----FIVDT---- 306
            ...|.|||||.: ||.|.:.|.|||||  |. .||..||.:|. .:.::..|    ::|||
Human   184 SKERVPVLSYLYKENNAAICRCSQPLS--GFYTRCVDDELLLE-AISQTNPGSQFMYVVDTRPKL 245

  Fly   307 -------WGKGKSNTETDLHYSQWKKVNRSIGNVSSPASILDSFARLIEACNDLGCSTDKWLSRL 364
                   .|||..|.:   :|:..:.....|.|:....|   |..:|:|.|.....:..::||.|
Human   246 NAMANRAAGKGYENED---NYANIRFRFMGIENIHVMRS---SLQKLLEVCELKTPTMSEFLSGL 304

  Fly   365 ENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGLDSTLIVTSLVQIILNPDCRTVRGLQAL 429
            |:||||..:...::|...:.:.:..|.:.||||.:.|.|.|..|.|:..|:|:|..||.:||..|
Human   305 ESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMIL 369

  Fly   430 IEREWIQAGHPFASRHRYSCYTPNQTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFE 494
            ||:|||..||.|:.|..:.     ...:|.....|..|||||:||..||||:|||:...|:.:.:
Human   370 IEKEWISMGHKFSQRCGHL-----DGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHD 429

  Fly   495 HSHFSQYGTFLCDSERERNELNVHTRTTSLWSYL--NRPDVLQTFLNPLYE--PNANVIWPSVAP 555
            |....|:|.||.:.:::|.:|.|:.:|.|:|.:|  .:||    |.||||:  ....|:.||..|
Human   430 HVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPD----FRNPLYKGFTMYGVLNPSTVP 490

  Fly   556 ISLELWSDLYLRWVIDQRSSVTVMSQIQELVTREKELRTQALKLRKQAM---ELGQEVSNLMKSG 617
            .:::.|..:|.|:....:...:::..:.|:..:...|.|...:|.|:..   |..:|:....:.|
Human   491 YNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLG 555

  Fly   618 N 618
            |
Human   556 N 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5026	NP_648271.3	PH-GRAM_MTMR9	1..106	CDD:275398	33/111 (30%)
		Myotub-related	210..512	CDD:461958	111/318 (35%)
MTMR8	NP_060147.2	PH-GRAM_MTMR8	1..103	CDD:270153	36/116 (31%)
		PTP-MTMR8	126..433	CDD:350432	113/382 (30%)