DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5026 and mtmr4

DIOPT Version :9

Sequence 1:	NP_001163392.1	Gene:	CG5026 / 39026	FlyBaseID:	FBgn0035945	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	XP_002667032.4	Gene:	mtmr4 / 393584	ZFINID:	ZDB-GENE-040426-1208	Length:	1107	Species:	Danio rerio

Alignment Length:	559	Identity:	158/559 - (28%)
Similarity:	251/559 - (44%)	Gaps:	118/559 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 IDCVEKKPSLSQNIVVGGIITLKCKDLRIISLEIKCGKEFFNVAASLEALSAIQNTELLYPFFYR 123
            |:.||.:.....:|:        |||.::    ::|  .|.......|.|..:|.. :.:|
Zfish    88 IESVESRDMFQLHII--------CKDSKV----VRC--HFSTFKQCEEWLKRLQRA-ITHP---- 133

  Fly   124 PMYSILEDGYTMFRPELEFAKLISGVGMGGASSPNVANITICMPSTSTSTLTVGAGIPHPLQNGY 188
                        .|.|..||.......:|..:.....::.:|.|         |..:.|.|:
Zfish   134 ------------ARLEELFALAYHAWCLGANTDDEDQHLHLCRP---------GDHVRHRLE--- 174

  Fly   189 AIEALACGVGGVGGGALQSPQASCEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDG 253
             :|....|..      :|:     .||::::|.::.:|::|...|:||..|||:::...|:||..
Zfish   175 -VEVKRMGFD------MQN-----AWRVSDINTNYKLCSSYPQKLLVPVWITDKELESVASFRSW 227

  Fly   254 GRFPVLSYRHE-NGATLMRSSQP-LSIQGIKRCRADEAILNLV-----------LGRSR------ 299
            .|.||:.|||: |||.:.|.||| :|..|.:... ||.::..:           .||||
Zfish   228 KRIPVVVYRHQRNGAVIARCSQPEISWWGWRNTE-DEYLVTSIAKACQLDGGSRAGRSRGDGPDS 291

  Fly   300 ---------------------KGFIVD---------TWGKGKSNTETDLHYSQWKKVNRSIGNVS 334
                                 |..|:|         ...|| ...|.:.:|...:.:...:.|:.
Zfish   292 DSDFDSSLTGCPAPDSSAAAQKLLILDARSYTAAVANRAKG-GGCECEEYYPNCEVMFMGMANIH 355

  Fly   335 SPASILDSFARLIEACNDLGCSTDKWLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGA 399
               ||.:||..|...|:.:. ....|||.||::.||..:...|.|:.:|...|:::|.|||||.:
Zfish   356 ---SIRNSFQSLRAVCSQIP-DPGNWLSALESTRWLQHLSVMLKAASLVCSALERDGRPVLVHCS 416

  Fly   400 KGLDSTLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRHRYSC-YTPNQTRNKTSGAT 463
            .|.|.|..:.:|.:|:|:|..||:.|.|.|:|.||:..||.||.|    | :..|..........
Zfish   417 DGWDRTPQIVALAKILLDPFYRTIEGFQVLVETEWLDFGHKFADR----CGHQENGDDVSEQCPV 477

  Fly   464 FVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCDSERERNELNVHTRTTSLWSYL 528
            |:.:|||::||..||||.|||:...|:.|.:|::...||||||::.:||...||:.||.|:||.|
Zfish   478 FLQWLDCVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLCNNGKERETRNVYKRTCSIWSLL 542

  Fly   529 NRPDVLQTFLNPLYEP-NANVIWPSVAPISLELWSDLYL 566
            ...:  :.|.|.||.| :..|:.|.....:|:||:.:||
Zfish   543 RTGN--KNFQNFLYIPCHDMVLQPVCHTRALQLWTAVYL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5026	NP_001163392.1	PH-GRAM_MTMR9	1..106	CDD:275398	9/46 (20%)
CG5026	NP_001163392.1	Myotub-related	117..511	CDD:284109	124/443 (28%)
mtmr4	XP_002667032.4	PH-like	35..148	CDD:302622	17/90 (19%)
		Myotub-related	172..525	CDD:284109	114/377 (30%)
		FYVE_MTMR4	1023..1082	CDD:277272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010