Protein Alignment CG5026 and Mtmr12

DIOPT Version :10

• Sequence 1: NP_648271.3
• Gene: CG5026 / 39026
• FlyBaseID: FBgn0035945
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_001401964.1
• Gene: Mtmr12 / 310155
• RGDID: 1307902
• Length: 748
• Species: Rattus norvegicus
• Alignment Length: 677
• Identity: 137/677 - (20%)
• Similarity: 248/677 - (36%)
• Gaps: 212/677 - (31%)

  Fly    59 IDCVE---------KKPSLSQNIVVGGIITLKCKDLRIISLEIKCGKEFFNVAASLEALSAI--- 111
            :.||:         |||...|.......:.:.|||||::...::..||        |.:..|
  Rat   113 LHCVDQIYGVFDEKKKPLFGQLKKYPEKLVIHCKDLRVLHFCLRYTKE--------EEVKRIVSG 169

  Fly   112 -----QNTELLYPFFYRPMYSILEDGYTMFRPELEFAKLISGVGMGGASSPNVANITICMPSTST 171
                 |:.:||...|   ::|              :|..:.|.    |:.|....:....|
  Rat   170 IIHHTQSPKLLKRLF---LFS--------------YAAAVHGT----AADPRNCTVMFDTP---- 209

  Fly   172 STLTVGAGIPHPLQNGYAIEALACGVGGVGGGALQSPQASCEWRITNVNRDFSVCATYGATLIVP 236
                          ..:..|             |:..:.|.:::..:||..:.||....|..:||
  Rat   210 --------------KDWCWE-------------LERTKGSVKYKTVSVNEGYRVCDRLPAYFVVP 247

  Fly   237 KAITDEQIVLSAAFRDGGRFPVLSYRHENGATLMRSSQPLSIQGIKRCRADEAILNLVLGRSRKG 301
            ..:.::.:   ..|:..| .|:..:...||:.|::.|      .:.:.:.|.|:      :.:|.
  Rat   248 TPLLEDDV---KRFQGRG-IPIWCWSCHNGSALLKMS------ALPKEQDDSAL------QIQKS 296

  Fly   302 FIVDTWGKGKSNTETDLHYSQWKKVNRS--IGNVSSPASILDSFAR-----LIEACNDLGCSTDK 359
            |:     .|...|   :|...::.|...  ..|..|...|..|:.:     ||::.::...:..|
  Rat   297 FL-----DGIYKT---IHRPPYEMVKTEDLSSNFLSLQEIQSSYCKFKQLFLIDSSSEFWDTDVK 353

  Fly   360 WLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGLDSTLIVTSLVQIILNPDCRTVR 424
            |.|.||:||||.::...|..:..:.:||:.:...||:......|...:::||||::::..|||..
  Rat   354 WFSLLESSGWLDIIRRCLKRAIEIIECLEAQNMNVLLLEENASDLCCLLSSLVQVMMDAHCRTWT 418

  Fly   425 GLQALIEREWIQAGHPFASRHRYSCYTPNQTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLL 489
            |.|:||::||:..||.|..|    |...:|: :|.....|:|||||::||..|.|.:|||:...|
  Rat   419 GFQSLIQKEWVMGGHSFLDR----CNHLHQS-DKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYL 478

  Fly   490 ILLFEHSHFSQYGTFLCDSERE------RNELNVHTRTTSL-----WSYLNRPDVLQTFLNPLY- 542
            .:|.:..:...:.||..:|..:      |..|:..::..:|     ||....|.......||||
  Rat   479 TVLSDSLYIPIFSTFFFNSPHQKDTNMGRESLDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYV 543

  Fly   543 --------------------------------------EPNANVI-------------------- 549
                                                  |...::|
  Rat   544 EKPKLDKGQRKGSRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDDLQD 608

  Fly   550 --------W------------PSVAPISLELWSDLYLRWVIDQR----SSVTVMSQIQELVTREK 590
                    |            |.:....:::|:..||||:.:.:    ..|..|.::.|::.
  Rat   609 NSREFYDNWHSKPTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGRVATMGKLLEMME--- 670

  Fly   591 ELRTQALKLRKQAMELGQEVSNLMKSG 617
              ..|:|:.:.:|....||..::...|
  Rat   671 --EVQSLQEKIEARHHRQEAIHVQAPG 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5026	NP_648271.3	PH-GRAM_MTMR9	1..106	CDD:275398	13/55 (24%)
		Myotub-related	210..512	CDD:461958	82/314 (26%)
Mtmr12	NP_001401964.1	PH-like	26..192	CDD:473070	21/103 (20%)
		PTP-MTMR12	261..463	CDD:350442	61/227 (27%)
		Interaction with MTM1. /evidence=ECO:0000250	450..559		28/108 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..576		0/26 (0%)
		3-PAP	560..686	CDD:463634	15/130 (12%)