DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5026 and Mtmr9

DIOPT Version :9

Sequence 1:	NP_001163392.1	Gene:	CG5026 / 39026	FlyBaseID:	FBgn0035945	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_001005761.1	Gene:	Mtmr9 / 282584	RGDID:	628840	Length:	549	Species:	Rattus norvegicus

Alignment Length:	624	Identity:	275/624 - (44%)
Similarity:	375/624 - (60%)	Gaps:	97/624 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEFADLIKTPKLDGVLLHDPSNAGASGATVGTLCITGHHLLLSARQETSQELWLLHKNIDCVEKK 65
            ||||:|||||::|.|:||.|...    |..||||:|||||:||:||:.::||||||.|||.::|:
  Rat     1 MEFAELIKTPRVDNVVLHRPFYP----AVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDKR 61

  Fly    66 PSLSQNIVVG--GIITLKCKDLRIISLEIKCGKEFFNVAASLEALSAIQNTELLYPFFYRPMYSI 128
                   .||  |.|.:||||.|||.|:|...:|..|:|:|:||||.:.:..|:||||||||:.:
  Rat    62 -------FVGSLGTIIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSVTLMYPFFYRPMFEV 119

  Fly   129 LEDGYTMFRPELEFAKLISGVGMGGASSPNVANITICMPSTSTSTLTVGAGIPHPLQNGYAIEAL 193
            :|||:..|.||.||.                      ..|::||
  Rat   120 IEDGWHSFLPEQEFE----------------------FYSSATS--------------------- 141

  Fly   194 ACGVGGVGGGALQSPQASCEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPV 258
                               |||::.||::||:|.||..|:||||:|.||.:...||||.||||||
  Rat   142 -------------------EWRLSYVNKEFSICPTYPPTVIVPKSIDDEALRKVAAFRHGGRFPV 187

  Fly   259 LSYRH-ENGATLMRSSQPLSIQGIKRCRADEAILNLVLGRSRKGFIVDT---------WGKGKSN 313
            |||.| :||..:|||.|||:....:||:.||.::|..|...::|:::||         ..|| ..
  Rat   188 LSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGYLIDTRSLNVAQQARAKG-GG 251

  Fly   314 TETDLHYSQWKKVNRSIGNVSSPASILDSFARLIEACNDLGCSTDKWLSRLENSGWLSLVLNSLN 378
            .|.:.||.||:::::||....   .:.:|..:|:||||:...|.|:||.:||.|.||:.:...|.
  Rat   252 FEQEAHYPQWRRIHKSIERYH---VLQESLIKLVEACNEQTHSMDRWLGKLEASNWLTHIKEILT 313

  Fly   379 ASCVVAQCLDQEGSPVLVHGAKGLDSTLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFAS 443
            .:|:.|||:|:||:.||:||.:|.||||.||||.||||.|..||:||.:|||||||:||||||..
  Rat   314 TACLAAQCIDREGASVLIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQ 378

  Fly   444 RHRYSCYTPNQTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCDS 508
            |...|.|.  .::.|.....|:|||||::|:..||||||||:...||:||||::.||:||||.:|
  Rat   379 RCAQSAYC--SSKQKWEAPVFLLFLDCVWQILRQFPCSFEFNEHFLIMLFEHAYASQFGTFLGNS 441

  Fly   509 ERERNELNVHTRTTSLWSYLNRPDVLQTFLNPLYEPNANVIWPSVAPISLELWSDLYLRWVIDQR 573
            |.||.:|.:..:|.||||::|||..|..|.|||:|.|..||||||||.||:||..::|||   .|
  Rat   442 ENERCKLKLQQKTMSLWSWVNRPSELSKFTNPLFEANNLVIWPSVAPQSLQLWEGIFLRW---SR 503

  Fly   574 SSVTVMSQIQELVT---REKELRTQALKLRKQAMELGQE 609
            ||..:....:|:|.   ..|||:.:...||:|..||..|
  Rat   504 SSKYLDEAYEEMVNIIEYNKELQAKVNVLRRQLAELETE 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5026	NP_001163392.1	PH-GRAM_MTMR9	1..106	CDD:275398	55/106 (52%)
CG5026	NP_001163392.1	Myotub-related	117..511	CDD:284109	168/403 (42%)
Mtmr9	NP_001005761.1	PH-GRAM_MTMR9	1..97	CDD:275398	55/106 (52%)
Mtmr9	NP_001005761.1	Myotub-related	121..446	CDD:399535	161/392 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349518
Domainoid	1	1.000	347	1.000	Domainoid score	I1003
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9148
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1167
OMA	1	1.010	-	-		QHG47990
OrthoDB	1	1.010	-	-		D192248at33208
OrthoFinder	1	1.000	-	-		FOG0006594
OrthoInspector	1	1.000	-	-		oto96665
orthoMCL	1	0.900	-	-		OOG6_106188
Panther	1	1.100	-	-	LDO	PTHR10807
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4139
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770