DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5026 and Mtmr10

DIOPT Version :9

Sequence 1:	NP_001163392.1	Gene:	CG5026 / 39026	FlyBaseID:	FBgn0035945	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_766330.2	Gene:	Mtmr10 / 233315	MGIID:	2142292	Length:	771	Species:	Mus musculus

Alignment Length:	783	Identity:	163/783 - (20%)
Similarity:	286/783 - (36%)	Gaps:	260/783 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KTPKLDGVLLHDPSNAGASGATVGTLCITGHHLLLSARQETSQ-ELW--LLHKN----------- 58
            |..||:.|||  |.....:.......||.         .:||| :||  |:..|
Mouse    30 KIKKLEPVLL--PGEIVVNEVNFVRKCIA---------TDTSQYDLWGKLICSNFKISFITDDPM 83

  Fly    59 ------------------IDCVEKKPSLS----QNIVVGGIITLK---------CKDLRIISLEI 92
                              :.|:|:..:::    :..|:|....||         |||.||:....
Mouse    84 PLQKFHYRNLLLGEHDVPLTCIEQIVTVNDHKRKQKVLGPNQKLKFNPTELIIYCKDFRIVRFRF 148

  Fly    93 -KCGKEFF-NVAASLEALSAIQNTELLYPFFYRPMYSILEDGYTMFRPELEFAKLISGVGMGGAS 155
             :.|.|.. .|..::...|...:.:||:.|.|            :.:.....|..::||..||..
Mouse   149 DESGPESAKKVCLAIAHYSQPTDLQLLFAFEY------------VGKKYHNSANKVNGVSSGGGG 201

  Fly   156 SPNVANITICMPSTSTSTLTVGAGIP----HPLQNGYA---IEALACGVGGVGGGALQSPQASCE 213
                              :..|||..    .||...|:   .|....|..|
Mouse   202 ------------------VWSGAGSTGSQRTPLFETYSDWDRETKRTGASG-------------- 234

  Fly   214 WRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRHENGATLMRSSQPLSI 278
            ||:.::|..:.:........:||.::.|:.:.:.:....|.|.|...:.|.||:.|:|.:  |..
Mouse   235 WRVCSINEGYMISTCLPEYFVVPSSLADQDLKIFSHSFVGRRMPFWCWSHSNGSALVRMA--LIK 297

  Fly   279 QGIKRCRADEAILNLVLGRSRKGFIVDTWGKGKSNTE-TDLHYSQWKKVNRSIGNVSSPASILDS 342
            ..:::.:.|:.|.|.:.               ||:.: :|::.|.   :::::.|:.   .|..:
Mouse   298 DALQQRKIDQRICNAIT---------------KSHPQRSDVYKSD---LDKALPNIQ---EIQAA 341

  Fly   343 FARLIEAC-NDLGCST-DKWLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGLDST 405
            |.:|.:.| |:....| :||||.||::.||..|...|..|..:...|:.:...|::...:|.|.:
Mouse   342 FVKLKQLCVNEPFEETEEKWLSSLESTRWLEYVRAFLKHSAELVYILESQRLSVVLQEEEGRDLS 406

  Fly   406 LIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRHRYSCYTPNQTRNKTSGATFVLFLDC 470
            .:|.||:|::::|..||:.|.|:||::||:.||:.|..|..:      ..|::.....|:||||.
Mouse   407 CLVASLIQVMMDPYFRTITGFQSLIQKEWVMAGYQFLDRCNH------LKRSEKESPLFLLFLDT 465

  Fly   471 IYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCDSERERNELNVH--------------TRT 521
            .:||..|:|.:||||...|.:|.:.:..|.:||||.:|..:|.:.:..              .:.
Mouse   466 TWQLLEQYPAAFEFSETYLAVLCDSTRISLFGTFLFNSPHQRVKQSTEFAISKNIQLGDEKGLKF 530

  Fly   522 TSLWSYLNRPDVLQ-------TFLNPLY------------------------------------- 542
            .|:|.:     .||       .|.||.|
Mouse   531 PSVWDW-----ALQFTAKDRTLFHNPFYIGKSTPCVQNGSRKSFKRTKKSYSSTLRGMPSCLKNG 590

  Fly   543 ------------------EPN-----------------------AN---VIWPSVAPISLELWSD 563
                              :|:                       ||   :|.|.::...::||..
Mouse   591 IITDQDLLPRRNSLVLKLKPDPPQHTDSQHSGAEQYFKEWFSRPANLHGIILPRLSGTHIKLWKL 655

  Fly   564 LYLRWV----IDQRSSVTVMSQIQELVTREKELRTQALKLRKQA------MELGQEVSNLMKSG- 617
            .|.|||    |:...|:....:: .|:..|.::.::.|:..:..      .||.|.......:|
Mouse   656 CYFRWVPEAQINLGGSIMAFHKL-SLLADEVDMLSRMLRQHRSGPLEACYAELDQSRMYFRATGP 719

  Fly   618 NDT 620
            :||
Mouse   720 HDT 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5026	NP_001163392.1	PH-GRAM_MTMR9	1..106	CDD:275398	30/144 (21%)
CG5026	NP_001163392.1	Myotub-related	117..511	CDD:284109	100/403 (25%)
Mtmr10	NP_766330.2	PH-GRAM_MTMR10	21..193	CDD:270154	36/185 (19%)
		PTPc	222..503	CDD:304379	85/323 (26%)
		3-PAP	574..701	CDD:289355	16/127 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740