Protein Alignment CG5026 and mtm-6

DIOPT Version :10

• Sequence 1: NP_648271.3
• Gene: CG5026 / 39026
• FlyBaseID: FBgn0035945
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_871680.1
• Gene: mtm-6 / 176757
• WormBaseID: WBGene00003478
• Length: 782
• Species: Caenorhabditis elegans
• Alignment Length: 652
• Identity: 178/652 - (27%)
• Similarity: 288/652 - (44%)
• Gaps: 145/652 - (22%)

  Fly    12 LDGVLLHDPSNAGASGATVGTLCITGHHLLLSARQETSQELWLLHKNIDCVEKKPSLSQNIVVGG 76
            :|.|.|.|  ..|.....|||:.:|..|::..| :..|:||||....|..|||    ......|.
 Worm   117 VDKVCLVD--RLGCQENLVGTVHVTTTHIIFRA-ENGSKELWLATGLISSVEK----GTLTAAGC 174

  Fly    77 IITLKCKDLRIISLEIKCGKEFFNVAASLEALSAIQNTELLYPFFYRPMYSILEDGYTMFRPELE 141
            ::.::||..::|:|.|...|.                        .:.:|..|:
 Worm   175 MLVIRCKHFQVITLLISRDKS------------------------CQDLYETLQ----------- 204

  Fly   142 FAKLISGVGMGGASSPNVANITICMPSTSTSTLTVGAGIPHPLQNGYAIEALACGVGGVGGGALQ 206
                       .|:.|...|:|..:...:.          .|:::......|.........|..:
 Worm   205 -----------RAAKPVSVNVTELLAFENR----------EPVEDVRGWRRLDWNSEMTRQGITK 248

  Fly   207 SPQASCEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRH-ENGATLM 270
            |     :|..:|:|..:::|.||...|..|.|.:...::.|..||..||.|||:|.| :..|.|.
 Worm   249 S-----QWTESNINEGYTICDTYPNKLWFPTAASTSVLLGSCKFRSRGRLPVLTYFHQQTEAALC 308

  Fly   271 RSSQPLSIQGIK-RCRADEAILNLVLGRSRKG----FIVDT-----------WGKGKSNTETDLH 319
            |.:|||:  |.. ||..||.::.|| |::...    |:|||           .|||   .|.:.:
 Worm   309 RCAQPLT--GFSARCVEDEKLMELV-GKANTNSDNLFLVDTRPRVNAMVNKVQGKG---FEDERN 367

  Fly   320 YSQWKKVNRSIGNV----SSPASILDSFARLIEACNDLGCSTDKWLSRLENSGWLSLVLNSLNAS 380
            ||..:.....|.|:    :|.|.:||:    :..|.|:   |:.| ..||.||||..|.:.:..|
 Worm   368 YSNMRFHFFDIENIHVMRASQARLLDA----VTKCRDV---TEYW-KTLEASGWLKHVRSVVECS 424

  Fly   381 CVVAQCLDQEGSPVLVHGAKGLDSTLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRH 445
            ..:|:.:.: |:..:||.:.|.|.|..|.:|.|::|:|..||:.|.|.|||::|:..||.|..|
 Worm   425 LFLAESISR-GTSCVVHCSDGWDRTSQVVALCQLLLDPYYRTIHGFQVLIEKDWLGFGHKFDDR- 487

  Fly   446 RYSC---YTPNQTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCD 507
               |   ...|....|.....|..:||||:|:..|.|.:|:|:.:.||.:.||.:..|:|||:.:
 Worm   488 ---CGHVGALNDEAGKEVSPIFTQWLDCIWQIMQQKPRAFQFNERYLIEMHEHVYSCQFGTFIGN 549

  Fly   508 SERERNELNVHTRTTSLWSYLN-RPDVLQTFLNPLYEPNANVIWPSVAPISLE-------LWSDL 564
            .:::|.:||:..||.|||:::: |.|   .::||.|.|.|:     ||.:.|:       :|:.:
 Worm   550 CDKDRRDLNLSKRTKSLWTWMDARHD---DYMNPFYSPTAH-----VALLDLDTRAARFTVWTAM 606

  Fly   565 YLRW-------------VIDQRSSVTVM-SQIQELVTREKELRTQALKLRKQAMELGQEVSNLMK 615
            |.|:             .:.....|.|: |.:.:|.||..||:||    :.|.:......:|::.
 Worm   607 YNRFDNGLQPRERLEDLTMAAMEHVGVLESHVAQLRTRLAELKTQ----QNQQITSTNTPTNMVD 667

  Fly   616 SG 617
            ||
 Worm   668 SG 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5026	NP_648271.3	PH-GRAM_MTMR9	1..106	CDD:275398	27/93 (29%)
		Myotub-related	210..512	CDD:461958	106/325 (33%)
mtm-6	NP_871680.1	PH-like	117..209	CDD:473070	30/144 (21%)
		PTP-MTMR6-like	237..540	CDD:350380	104/326 (32%)
		FYVE	724..782	CDD:214499