DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5026 and mtmr4

DIOPT Version :9

Sequence 1:	NP_001163392.1	Gene:	CG5026 / 39026	FlyBaseID:	FBgn0035945	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	XP_004911826.1	Gene:	mtmr4 / 100151726	XenbaseID:	XB-GENE-986315	Length:	1093	Species:	Xenopus tropicalis

Alignment Length:	566	Identity:	157/566 - (27%)
Similarity:	244/566 - (43%)	Gaps:	126/566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 IDCVEKKPSLSQNIVVGGIITLKCKDLRIISLEIKCGKEFFNVAASLEALSAIQNTELLYPFFYR 123
            |:.||.:......|:        |||.::    ::|  .|.......|.|..:....|      |
Frog    90 IEAVESRDMFQLQII--------CKDSKV----VRC--HFSTFKQCQEWLKRLSRATL------R 134

  Fly   124 PMYSILEDGYTMFRPELEFAKLISGVGMGGASSPNVANITICMPSTSTSTLTVGAGIPHPLQNGY 188
            |.           :.|..||........|..:......|.:|.|...             :::.:
Frog   135 PA-----------KQEDLFAFAYHAWCQGICTDEEEPLIHLCRPGDH-------------VKSRF 175

  Fly   189 AIEALACGVGGVGGGALQSPQASCEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDG 253
            .:|.:..|..      ||:     .||::.:|.::.:|.:|...|:||..|||:::...|:||..
Frog   176 QMELVRMGFD------LQN-----AWRVSEINNNYKLCPSYPQKLLVPVWITDKELENVASFRSW 229

  Fly   254 GRFPVLSYRH-ENGATLMRSSQP-LSIQG-------------IKRCRADEAILNLVLGRSRKGFI 303
            .|.||:.||| ..||.:.|.||| :|..|             .|.|..:.|:      |...|..
Frog   230 KRIPVVVYRHTRTGAVIARCSQPEISWWGWRNADDEYLVTSIAKACALNPAV------RMPNGNA 288

  Fly   304 VDTWGK-GKSNTETDLHYSQW----------KKV-------------NRSIG------------- 331
            .....| |..|::||...|..          :|:             ||:.|
Frog   289 SSKENKDGSDNSDTDFDSSLTACPVEGGGVPQKLLIVDARSYTAAVANRAKGGGCECEEYYPNCE 353

  Fly   332 ----NVSSPASILDSFARLIEACNDLGCSTDKWLSRLENSGWLSLVLNSLNASCVVAQCLDQEGS 392
                .:::..||.:||..|...||.:. ....|||.||::.||..:...|.|:.|||..:|:|..
Frog   354 VAFMGMANIHSIRNSFQYLRAVCNQVP-DPGNWLSALESTKWLQHLSAMLKAATVVANAVDREER 417

  Fly   393 PVLVHGAKGLDSTLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRHRYSCYTPNQTRN 457
            |||||.:.|.|.|..:.||.:::|:|..||:.|.|.|:|.:|:..||.||.|    |.....|.:
Frog   418 PVLVHCSDGWDRTPQIVSLAKLLLDPYYRTLEGFQVLVETDWLDYGHKFADR----CGHQENTED 478

  Fly   458 KTSGA-TFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCDSERERNELNVHTRT 521
            :.... .|:.:||||:||..||||.|||:...|:.|.:|::...|||||.::..||...|::.||
Frog   479 QNEQCPVFLQWLDCIHQLLLQFPCHFEFNHAFLVKLVQHTYSCLYGTFLANNLCEREMRNIYKRT 543

  Fly   522 TSLWSYLNRPDVLQTFLNPLYEPNANVIWPSVAPI-SLELWSDLYL 566
            .|:||.|...:  :.|.|.||.|.::::...|..: :|:||:.:||
Frog   544 CSVWSLLRTGN--KNFHNLLYMPGSDLVLHPVCHVRALQLWTAVYL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5026	NP_001163392.1	PH-GRAM_MTMR9	1..106	CDD:275398	9/46 (20%)
CG5026	NP_001163392.1	Myotub-related	117..511	CDD:284109	125/450 (28%)
mtmr4	XP_004911826.1	PH-GRAM_MTMR4	37..150	CDD:270150	17/90 (19%)
		PTP-MTMR4	188..495	CDD:350435	95/322 (30%)
		FYVE_MTMR4	1009..1068	CDD:277272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920