Protein Alignment KDM4E and Kdm4d

DIOPT Version :9

• Sequence 1: NP_001155102.1
• Gene: KDM4E / 390245
• HGNCID: 37098
• Length: 506
• Species: Homo sapiens
• Sequence 2: NP_001073180.1
• Gene: Kdm4d / 689582
• RGDID: 1591045
• Length: 510
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 321/520 - (61%)
• Similarity: 365/520 - (70%)
• Gaps: 44/520 - (8%)

Human     1 MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDDIED 65
            ||:..:..||.:.:||.|.||.|||.||:.|:|||||||||:||||||||||||:|||.||:|.:
  Rat     1 MKTKSTCAQNPNCSIMIFRPTKEEFNDFDKYIAYMESQGAHRAGLAKVIPPKEWRARQSYDNISN 65

Human    66 ILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNP 130
            ||||||||||.|||.|||||||||||||.|||||.||||||||||||.:|.|||::|||:.....
  Rat    66 ILIATPLQQVVSGQAGVFTQYHKKKKAMTVGQYRHLANSKKYQTPPHLDFEDLERKYWKNRLYES 130

Human   131 PIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDL 195
            ||||||:|||||:..|:|||:||||||.||||||||:|||||||||||||||||:||||||||||
  Rat   131 PIYGADVSGSLFDGKTQQWNVGHLGTIQDLLEQECGIVIEGVNTPYLYFGMWKTSFAWHTEDMDL 195

Human   196 YSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNC 260
            |||||||||:|||||.||||||:.||.||:||||..|:||:||||||||||||||||||||||..
  Rat   196 YSINYLHFGQPKTWYAVPPEHGRRLELLAKELFPGSSQGCQAFLRHKVALISPTVLKENGIPFGR 260

Human   261 MTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIV 325
            :|||||||||||||||||||||||||||||||||||||||||:||||||||:.|:||||.||||:
  Rat   261 ITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVSFSMDAFVRIL 325

Human   326 QPESYELWKHRQDLAIVEHTEPRVAESQELSNWRDDIVLRRAALGLR----------LLPNLTAQ 380
            |||.||:||..||.|:|:|||.....||||:.|| .|...|...||:          |||..|
  Rat   326 QPERYEMWKRGQDQAVVDHTEAMGPTSQELTTWR-VIQAPRKTWGLKHLRLRQVSRCLLPVAT-- 387

Human   381 CPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLTLGMSARVLLPSTGSWGSG-RGRGRG 444
                  .|....|.:.|.|..   .|..|.....|.....:.....:.|.|.|...:| ||.||
  Rat   388 ------DSNIANNTQMCHTSR---QAADSKGDEVQESDPAIAPPYPLGLSSPGHMSTGKRGLGR- 442

Human   445 QGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLLMGTRSRAQGHRPQL---PLANDLMTNLSL 506
                |.|           |||.:|.|.....||||..|...|:..  |:|   .:..||:.|..|
  Rat   443 ----RPC-----------ELGVQESTNGAPVKRRLPEGRDDRSPS--PELQSQSVTGDLIVNSDL 490

Human   507  506
              Rat   491  490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM4E	NP_001155102.1	JmjN	16..50	CDD:280526	25/33 (76%)
		JmjC	176..292	CDD:202224	101/115 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..473		13/41 (32%)
Kdm4d	NP_001073180.1	JmjN	15..55	CDD:128818	31/39 (79%)
		JmjC	176..292	CDD:202224	101/115 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..510		32/115 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I19888
eggNOG	1	0.900	-	-		E1_COG5141
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58782
OrthoDB	1	1.010	-	-		D104000at40674
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_111638
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.790