DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5653 and FMS1

DIOPT Version :9

Sequence 1:	NP_648269.1	Gene:	CG5653 / 39024	FlyBaseID:	FBgn0035943	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_013733.1	Gene:	FMS1 / 855034	SGDID:	S000004622	Length:	508	Species:	Saccharomyces cerevisiae

Alignment Length:	564	Identity:	130/564 - (23%)
Similarity:	217/564 - (38%)	Gaps:	167/564 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ASSRIIIIGAGVSGIAAATRLLQNNFQNVQILEAEDRIGGRINTV--YFGDNVIDLGAQWCHGKQ 68
            |..::||||||::|:.||:.|.||..|:..:|||.||:|||:.||  |.| ...|:||.|.|...
Yeast     7 AKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQG-RKYDIGASWHHDTL 70

  Fly    69 QN-----------------CVYDMVKDMGILHETGDYYSPIKRVRSNK----EVVPHELACRIHD 112
            .|                 .|:|....:.|..|.|       ||..:|    |:|.:|:: :..:
Yeast    71 TNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERG-------RVDHDKELLLEIVDNEMS-KFAE 127

  Fly   113 IAVKSMPSGPHPVVGSFGTHL---TQTFWRKIESELPQVNRDVASEALNTFAKHESSIIGADNLF 174
            :              .|..||   ..:|::.:...|.|..:.:.::.:.               :
Yeast   128 L--------------EFHQHLGVSDCSFFQLVMKYLLQRRQFLTNDQIR---------------Y 163

  Fly   175 EVSVREHIE-YHECDGDKLL-----HWGTKGYRRFL----RLLMKVSADTPEELGLLEGRIQLDM 229
            ...:..::| :|..|. |||     ::|.:|...|.    .::.:::...|:..      ::|..
Yeast   164 LPQLCRYLELWHGLDW-KLLSAKDTYFGHQGRNAFALNYDSVVQRIAQSFPQNW------LKLSC 221

  Fly   230 KVIKIELACPRKVILRCQDGDYFEADHVICTVSLGV--LQEQHEK------LFVPPLPAAKVNAI 286
            :|..|.....:.|.:.|:||..:.||:||.||...|  |..|.||      .|.|||.....:|.
Yeast   222 EVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQPPLKPVIQDAF 286

  Fly   287 RSLTLGTVNKLYLEYEKQPLPDGWVGFFCFWLEED--LIELRKTEYFWVEGITGVH--------- 340
            ..:..|.:.|:..|:|:           |.|..|.  ::.|..:...:||.:....
Yeast   287 DKIHFGALGKVIFEFEE-----------CCWSNESSKIVTLANSTNEFVEIVRNAENLDELDSML 340

  Fly   341 ---------MITC--QP------------RMLMAWVNGPHGRHMETLSDEKVLEGLYWLFRKFL- 381
                     .:||  ||            ...|..:..|...|:|::.::|  |.|:..|:..|
Yeast   341 EREDSQKHTSVTCWSQPLFFVNLSKSTGVASFMMLMQAPLTNHIESIREDK--ERLFSFFQPVLN 403

  Fly   382 ----------------------TFEIPPPKRFVRSSWFSNPNFRGSWSYRGVMADERNTGPWDLE 424
                                  ....|..:..:.|:|..:|..||::|     |......|.|:.
Yeast   404 KIMKCLDSEDVIDGMRPIENIANANKPVLRNIIVSNWTRDPYSRGAYS-----ACFPGDDPVDMV 463

  Fly   425 SPVL-GEDGHLGLLFAGEASSRNHFSTVHGAVEAGYREADRLID 467
            ..:. |:|..  :.||||.:..:.....:||.|:|.|||.|:.|
Yeast   464 VAMSNGQDSR--IRFAGEHTIMDGAGCAYGAWESGRREATRISD 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5653	NP_648269.1	NAD_binding_8	12..78	CDD:290186	32/84 (38%)
CG5653	NP_648269.1	Amino_oxidase	17..466	CDD:279874	122/550 (22%)
FMS1	NP_013733.1	Amino_oxidase	18..503	CDD:396255	121/549 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	1	1.000	-	-		otm46708
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870