DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5653 and paox

DIOPT Version :9

Sequence 1:	NP_648269.1	Gene:	CG5653 / 39024	FlyBaseID:	FBgn0035943	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001314981.1	Gene:	paox / 562105	ZFINID:	ZDB-GENE-090312-204	Length:	510	Species:	Danio rerio

Alignment Length:	539	Identity:	160/539 - (29%)
Similarity:	248/539 - (46%)	Gaps:	116/539 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SRIIIIGAGVSGIAAATRLLQNNFQNVQILEAEDRIGGRINTVYFGDNVIDLGAQWCHG-KQQNC 71
            |:|.|||.|:|||.||.:|:::.|.||:|:||..|.||||.|...|||:|::||.|.|| .::|.
Zfish    12 SQIFIIGCGISGIGAAQKLIKHGFHNVRIIEATARSGGRIRTGRLGDNIIEIGANWIHGPSKENP 76

  Fly    72 VYDMVKDMGILH-----------ETGDY--YSPIKRVRSNKEVVPH-------------ELACRI 110
            |:.:..|..:|.           :.|.:  :.|.....|.:::.|.             |.:.:.
Zfish    77 VFRLACDYQLLDKESMSEENQAIDIGGHPLFVPNWFTSSGRKLGPETMGPALEFFMTLLERSQQF 141

  Fly   111 HDIAVKSMPSGPHPVVGSF----GTHLTQTFWRKIESELPQVNRD---VASEALNTFAKHESSII 168
            |....:.:||     ||.|    ...|....|::        :||   |....:||..|.|..:.
Zfish   142 HSTGGEPLPS-----VGEFIKAEAERLAPEEWKE--------DRDNFAVRMAMINTLLKLECCVS 193

  Fly   169 GADNLFEVSVREHIEYHECDGDKLLHWGTKGYRRFLRLLMKVSADTPEELGLLEGRIQLDMKVIK 233
            |...:.:|.:.....|....|......|  ||......:||   :.|.::.|..       |.:|
Zfish   194 GTHTMDDVGLGAFGMYTTLPGLDCTFPG--GYEGLTDHMMK---ELPRDIVLYN-------KPVK 246

  Fly   234 IELAC---------PR------KVILRCQDGDYFEADHVICTVSLGVLQEQHEKLFVPPLPAAKV 283
                |         |.      .|.:.|.:|:.|.|||||.||.||.:::.......|..|..|:
Zfish   247 ----CIHWNYTKNGPNTGGTSFPVTIECVNGETFAADHVIVTVPLGYMKKHQNTFLSPSFPLHKL 307

  Fly   284 NAIRSLTLGTVNKLYLEYEKQPLPDGWVGFFCFWLEE-DLI------ELRKTEYF------WVEG 335
            ::|:.:..||.||:::|:| ||          ||.|: :||      |...|:..      |:..
Zfish   308 HSIQRMGFGTNNKIFVEFE-QP----------FWDEDCELIYLVWEDETHLTDVVSDLKMSWIRK 361

  Fly   336 ITGVHMITCQPR---MLMAWVNGPHGRHMETLSDEKVLEGLYWLFRKFLTFEIPPPKRFVRSSWF 397
            :||..::....|   :|..|:.|....:||:||:.:||:.:..|.|.|.......|::.:||.||
Zfish   362 LTGFTVLKPTERFGHVLCGWIAGQESEYMESLSELEVLQTVTQLLRIFTGNPTIMPRKLLRSQWF 426

  Fly   398 SNPNFRGSWSYRGVMADERNTGPWDLES-----PVLGEDGH-LGLLFAGEASSRNHFSTVHGAVE 456
            ..|...||:||..     :....:|:::     |:.|.:.. |.:||||||:.|:.|||||||:.
Zfish   427 HEPYSCGSYSYVA-----KGCSGYDIDNLAEPLPLKGSNSKPLQVLFAGEATHRSFFSTVHGALL 486

  Fly   457 AGYREADRLIDHYTSCSVS 475
            :|:|||:|||.|:||.|.|
Zfish   487 SGWREAERLISHHTSASGS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5653	NP_648269.1	NAD_binding_8	12..78	CDD:290186	33/66 (50%)
CG5653	NP_648269.1	Amino_oxidase	17..466	CDD:279874	147/519 (28%)
paox	NP_001314981.1	Amino_oxidase	26..503	CDD:332356	149/521 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583675
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375579at33208
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102123
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.650