DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5653 and MAOA

DIOPT Version :9

Sequence 1:	NP_648269.1	Gene:	CG5653 / 39024	FlyBaseID:	FBgn0035943	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_000231.1	Gene:	MAOA / 4128	HGNCID:	6833	Length:	527	Species:	Homo sapiens

Alignment Length:	522	Identity:	114/522 - (21%)
Similarity:	209/522 - (40%)	Gaps:	140/522 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IIIIGAGVSGIAAATRLLQNNFQNVQILEAEDRIGGRINTVYFGDNV--IDLGAQWCHGKQQNCV 72
            :::||.|:||::|| :||.....:|.:|||.||:|||..|:. .::|  :|:|..:. |..||.:
Human    16 VVVIGGGISGLSAA-KLLTEYGVSVLVLEARDRVGGRTYTIR-NEHVDYVDVGGAYV-GPTQNRI 77

  Fly    73 YDMVKDMGILHETGDYYSPIKRVRSNKEVVPHELACRIHDIAVKSMP-SGPHPVVGSFGTHLT-Q 135
            ..:.|::||  ||       .:|..::.:|.:        :..|:.| .|..|.|.:...:|. .
Human    78 LRLSKELGI--ET-------YKVNVSERLVQY--------VKGKTYPFRGAFPPVWNPIAYLDYN 125

  Fly   136 TFWRKIESELPQVNRDVASEALNTFAKHESSIIGADNLFEVSVREHIEYHECDGDKLLHWGTKGY 200
            ..||.|::...::..|...|     |:|      ||...:::::|.|       ||:. | ||..
Human   126 NLWRTIDNMGKEIPTDAPWE-----AQH------ADKWDKMTMKELI-------DKIC-W-TKTA 170

  Fly   201 RRFLRLLMKVSADT-PEE------------------------------------------LGLLE 222
            |||..|.:.::..: |.|                                          :.||.
Human   171 RRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLG 235

  Fly   223 GRIQLDMKVIKIELACPRKVILRCQDGDYFEADHVICTVSLGVLQEQHEKLFVPPLPAAKVNAIR 287
            .:::|:..|..::.:.. .:|:...:.:::|..:||..:...:..:.|   |.|.|||.:...|:
Human   236 DQVKLNHPVTHVDQSSD-NIIIETLNHEHYECKYVINAIPPTLTAKIH---FRPELPAERNQLIQ 296

  Fly   288 SLTLGTVNKLYLEYEKQPLPDGWVGFFCFWLEED-----LIELRKTEYFWVEGITGVHMITCQP- 346
            .|.:|.|.|..:.|::           .||.::|     :||..       :....:.:...:|
Human   297 RLPMGAVIKCMMYYKE-----------AFWKKKDYCGCMIIEDE-------DAPISITLDDTKPD 343

  Fly   347 ---RMLMAWVNGPHGRHMETLSDE----KVLEGLYWLFRKFL-TFEIPPPKRFVRSSWFSNPNFR 403
               ..:|.::.......:..|..|    |:.|    |:.|.| :.|...|..:...:|.......
Human   344 GSLPAIMGFILARKADRLAKLHKEIRKKKICE----LYAKVLGSQEALHPVHYEEKNWCEEQYSG 404

  Fly   404 GSWSY---RGVMADERNTGPWDLESPVLGEDGHLGLLFAGEASSRNHFSTVHGAVEAGYREADRL 465
            |.::.   .|:|......    :..||    |.  :.|||..::......:.||||||.|.|..:
Human   405 GCYTAYFPPGIMTQYGRV----IRQPV----GR--IFFAGTETATKWSGYMEGAVEAGERAAREV 459

  Fly   466 ID 467
            ::
Human   460 LN 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5653	NP_648269.1	NAD_binding_8	12..78	CDD:290186	25/67 (37%)
CG5653	NP_648269.1	Amino_oxidase	17..466	CDD:279874	111/512 (22%)
MAOA	NP_000231.1	YobN	15..460	CDD:224152	114/519 (22%)
MAOA	NP_000231.1	Interaction with membrane phospholipid headgroups. /evidence=ECO:0000305	520..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840