DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5653 and CG7737

DIOPT Version :9

Sequence 1:	NP_648269.1	Gene:	CG5653 / 39024	FlyBaseID:	FBgn0035943	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001286308.1	Gene:	CG7737 / 36174	FlyBaseID:	FBgn0033584	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	214/493 - (43%)
Similarity:	306/493 - (62%)	Gaps:	28/493 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RIIIIGAGVSGIAAATRLLQNNFQNVQILEAEDRIGGRINTVYFGDNVIDLGAQWCHGKQQNCVY 73
            :|::||||.||:|.||:||:..||||.::|||||:||||:|:.|.|||||||||||||::.|.||
  Fly    45 KIVVIGAGASGVACATKLLELGFQNVLVVEAEDRLGGRIHTIPFADNVIDLGAQWCHGERDNIVY 109

  Fly    74 DMVK--DMGILHETGDYYSPIKRVRSNKEVVPHELACRIHDIAVKSMPSGP---HPVVGSFGTHL 133
            ::.:  |..:|..||..|...:.||||.:|||.|::.|:..|...|:.:..   ....||.|::|
  Fly   110 ELTRKQDEELLESTGPVYENYECVRSNGDVVPEEVSSRLKAIVGDSLVTRQLELRHCSGSLGSYL 174

  Fly   134 TQTFWRKI-ESELPQVNRDVASEALNTFAKHESSIIGADNLFEVSVREHIEYHECDGDKLLHWGT 197
            |..|:..: ..|...::.:||||....:.|.|:|:..:|.|.:||.|.:::|.||:||.||:|..
  Fly   175 TNKFYDTLRRPENSDIDAEVASEFFVNYQKFENSVEASDTLEQVSGRGYLDYWECEGDILLNWKD 239

  Fly   198 KGYRRFLRLLMKVSADTPEELGLLEGRIQLDMKVIKIEL-ACPRKVILRCQDGDYFEADHVICTV 261
            |||...|||||: |.:...|.|:||.|:.|..:|:||.. ....:|.|:..:|:...||||:.||
  Fly   240 KGYVELLRLLMR-SRELNVEHGVLEQRLLLGTRVVKINWNRNDGRVELQMSNGETCIADHVVVTV 303

  Fly   262 SLGVLQEQHEKLFVPPLPAAKVNAIRSLTLGTVNKLYLEYEKQPLPDGWVGFFCFWLEEDLIELR 326
            |||||::||.:||.|.||..|..||..|..|||||:::|:.:...|:.|.||...|.:|||.::|
  Fly   304 SLGVLKDQHLRLFEPQLPVEKQRAIDGLAFGTVNKIFVEFPEAFWPEDWTGFTMLWRDEDLDDIR 368

  Fly   327 KTEYFWVEGITGVHMITCQPRMLMAWVNGPHGRHMETLSDEKVLEGLYWLFRKFLTFEIPPPKRF 391
            .|...|:|.:.|.:.::.|||:|..|:....|||||||..::|..|:.:|||:||.::||.|..|
  Fly   369 GTSRAWLEDVFGFYRVSYQPRILAGWITNESGRHMETLPVDEVQAGVMYLFRRFLRWKIPDPANF 433

  Fly   392 VRSSWFSNPNFRGSWSYRGVMADERNTGPWDLESPVL-----------GED--------GHLGLL 437
            ..|:|::|.|||||:|||.:..::..||..:|..|:.           .||        ....:.
  Fly   434 RTSAWYTNDNFRGSYSYRSMDTEQLGTGARELSHPLTVVATTPEKDKDSEDEAWQQSRCDRPIVQ 498

  Fly   438 FAGEASSRNHFSTVHGAVEAGYREADRLIDHYTSCSVS 475
            |||||||.:::||||||||||:|||.||...| ..|||
  Fly   499 FAGEASSEHYYSTVHGAVEAGWREARRLAQFY-GISVS 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5653	NP_648269.1	NAD_binding_8	12..78	CDD:290186	42/67 (63%)
CG5653	NP_648269.1	Amino_oxidase	17..466	CDD:279874	204/474 (43%)
CG7737	NP_001286308.1	NAD_binding_8	48..106	CDD:290186	39/57 (68%)
CG7737	NP_001286308.1	Amino_oxidase	54..526	CDD:279874	203/472 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470246
Domainoid	1	1.000	158	1.000	Domainoid score	I1289
eggNOG	1	0.900	-	-		E1_KOG0685
Homologene	1	1.000	-	-		H77187
Inparanoid	1	1.050	177	1.000	Inparanoid score	I1474
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375579at33208
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	1	1.000	-	-		otm3237
orthoMCL	1	0.900	-	-		OOG6_102123
Panther	1	1.100	-	-	P	PTHR10742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X429
	12	11.800