DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5653 and Maoa

DIOPT Version :9

Sequence 1:	NP_648269.1	Gene:	CG5653 / 39024	FlyBaseID:	FBgn0035943	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_387502.1	Gene:	Maoa / 29253	RGDID:	61898	Length:	526	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	116/505 - (22%)
Similarity:	205/505 - (40%)	Gaps:	106/505 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IIIIGAGVSGIAAATRLLQNNFQNVQILEAEDRIGGRINTVYFGDNV--IDLGAQWCHGKQQNCV 72
            :::||.|:||:||| :||.....||.:|||.||:|||..||. .::|  :|:|..:. |..||.:
  Rat    16 VVVIGGGISGLAAA-KLLSEYKINVLVLEARDRVGGRTYTVR-NEHVKWVDVGGAYV-GPTQNRI 77

  Fly    73 YDMVKDMGILHETGDYYSPIKRVRSNKEVVPHELACRIHDIAVKSMP-SGPHPVVGSFGTHLT-Q 135
            ..:.|::||  ||       .:|..|:.:|.:        :..|:.| .|..|.|.:...:|. .
  Rat    78 LRLSKELGI--ET-------YKVNVNERLVQY--------VKGKTYPFRGAFPPVWNPLAYLDYN 125

  Fly   136 TFWRKIE---SELP--------------------QVNRDVASEALNTFAKHESSIIGADNLFEVS 177
            ..||.::   .|:|                    .:::...::....||....:|.......|||
  Rat   126 NLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVS 190

  Fly   178 VREHIEY-HECDGDKLLHWGTKG--YRRFLRLLMKVSADTPEELGLLEGRIQLDMKVIKIELACP 239
            ....:.| .:|.|...:...|.|  .|:|:....:||   .:.:|||..:::|...|..|: ...
  Rat   191 ALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVS---EQIMGLLGDKVKLSSPVTYID-QTD 251

  Fly   240 RKVILRCQDGDYFEADHVICTVSLGVLQEQHEKLFVPPLPAAKVNAIRSLTLGTVNKLYLEYEKQ 304
            ..:|:...:.:::|..:||..:...:..:.|   |.|.||..:...|:.|.:|.|.|..:.|::
  Rat   252 DNIIVETLNHEHYECKYVISAIPPILTAKIH---FKPELPPERNQLIQRLPMGAVIKCMVYYKE- 312

  Fly   305 PLPDGWVGFFCFWLEED-----LIELRKTEYFWVEGITGVHMITCQP----RMLMAWVNGPHGRH 360
                      .||.::|     :||..       |....:.:...:|    ..:|.::.......
  Rat   313 ----------AFWKKKDYCGCMIIEDE-------EAPIAITLDDTKPDGSLPAIMGFILARKADR 360

  Fly   361 METLSDE----KVLEGLYWLFRKFL-TFEIPPPKRFVRSSWFSNPNFRGSWSY---RGVMADERN 417
            :..|..:    |:.|    |:.|.| :.|...|..:...:|.......|.::.   .|:|.....
  Rat   361 LAKLHKDIRKRKICE----LYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGR 421

  Fly   418 TGPWDLESPVLGEDGHLGLLFAGEASSRNHFSTVHGAVEAGYREADRLID 467
            .    :..||    |.  :.|||..::......:.||||||.|.|..:::
  Rat   422 V----IRQPV----GR--IYFAGTETATQWSGYMEGAVEAGERAAREVLN 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5653	NP_648269.1	NAD_binding_8	12..78	CDD:290186	28/67 (42%)
CG5653	NP_648269.1	Amino_oxidase	17..466	CDD:279874	113/495 (23%)
Maoa	NP_387502.1	YobN	15..463	CDD:224152	116/505 (23%)
		NAD_binding_8	18..84	CDD:290186	29/68 (43%)
		Interaction with membrane phospholipid headgroups. /evidence=ECO:0000250	520..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840