DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5653 and lsd1

DIOPT Version :9

Sequence 1:	NP_648269.1	Gene:	CG5653 / 39024	FlyBaseID:	FBgn0035943	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_595398.1	Gene:	lsd1 / 2539805	PomBaseID:	SPBC146.09c	Length:	1000	Species:	Schizosaccharomyces pombe

Alignment Length:	563	Identity:	109/563 - (19%)
Similarity:	187/563 - (33%)	Gaps:	171/563 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEKCRASSRIIIIGAGVSGIAAATRLLQNNF--------------QNVQILEAEDRIGGRINT-- 49
            :::..:...:.|||||::||:.| |.|.|.|              ..:.|.||.:|:||.|.|
pombe   251 LDESLSQKTVAIIGAGMAGISCA-RQLTNLFAQYEQDFLSRGEKPPRIVIYEASERLGGHIYTHM 314

  Fly    50 VYFGDNVIDLGAQWCH--GKQQNCVYDMVKDMGILHETGDYYSPIKRVRS-----------NKEV 101
            |...||.:...:....  .....|:.:::.|..|...|.| ..|:..:.|           |:|.
pombe   315 VPLSDNEVSEKSSLATTVNATNECMVNLLTDSLIGMPTLD-SDPLYIISSQQLSLDAVHTRNREF 378

  Fly   102 VPHEL------------ACRIHDIAV---------KSMPSGPHPVVGSFGTHLTQTFWRKIESEL 145
            :.|::            ..|:.|..:         :.:.|...|....|...|.|..|.......
pombe   379 ILHDIENGRIDTEHVQRIFRLFDALLFYFNASASKQPLHSLITPPEQEFIQKLDQIGWYISIEAF 443

  Fly   146 PQVNRDVASEALNTFAKHESSIIGADNLFEVSVREHIEYHECDGDKLLHWGTKGYRRFLRLLMKV 210
            |...:|..||.|...|...:|::            |:...:.   |:..|    ::.:|...:.|
pombe   444 PLQIKDTLSEFLGNSANTLTSLL------------HLTVLDL---KIFEW----FKEYLSQSLSV 489

  Fly   211 S------------------------------------ADTPEELGLLEGRIQLDMKVIKIELACP 239
            |                                    |.||..|.:|..:.   :..:|:|   .
pombe   490 SLENVYPGSIPNLNLLLGENVASYSFKHGMADMLNSLASTPSPLPILFDQC---VHTVKLE---D 548

  Fly   240 RKVILRCQDGDYFEADHVICTVSLGVLQEQHEKLFVPPLPAAKVNAIRSLTLGTVNKLYLEYEKQ 304
            ..|.|...:......|.|:..:.:..| ..|...|.|||...|:.||.......|.|:.|.::.|
pombe   549 NTVNLSFVNETTVSVDKVVICIPMDKL-NTHLITFEPPLEEKKLKAIDRCHFTNVKKVILIFKTQ 612

  Fly   305 ----------PLPDGWVGFFCF-----WLEEDLIELRKTEYFWVEGITGVHMITCQPRMLMAWVN 354
                      .||......|.|     :.|...:.:    :..||||
pombe   613 FWEPNISIFGSLPQDSGRNFIFNDCTRFYEHPTLSV----FVKVEGI------------------ 655

  Fly   355 GPHGRHMETLSDEKVLEGLYWLFRKFL--TFEIPPPKRFVRSSWFSNPNFRGSWSYR--GVMADE 415
                   :.:.|:.::.|:....:|..  ..|...|.|.:.|:| .|.::....||:  .:..:|
pombe   656 -------DFMKDDDIVNGIVSQLKKVYKPKSEAINPIRTIISNW-ENNSYTNHSSYQISNLFLEE 712

  Fly   416 RNTGPWDLESPVLGEDGHLGLLFAGEASSRNHFSTVHGAVEAG 458
                    :..:|.|.....:.||.||.|:.:..::.||.::|
pombe   713 --------DYAILSEPIDNTVFFASEAISQKNSGSIRGAFDSG 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5653	NP_648269.1	NAD_binding_8	12..78	CDD:290186	24/83 (29%)
CG5653	NP_648269.1	Amino_oxidase	17..466	CDD:279874	104/547 (19%)
lsd1	NP_595398.1	SWIRM	157..240	CDD:282311
		NAD_binding_8	262..>316	CDD:290186	20/54 (37%)
		Amino_oxidase	267..755	CDD:279874	104/547 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870