Protein Alignment CG5653 and KDM1B

DIOPT Version :10

• Sequence 1: NP_648269.1
• Gene: CG5653 / 39024
• FlyBaseID: FBgn0035943
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_001426046.1
• Gene: KDM1B / 221656
• HGNCID: 21577
• Length: 832
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 135/499 - (27%)
• Similarity: 217/499 - (43%)
• Gaps: 106/499 - (21%)

  Fly    10 IIIIGAGVSGIAAATRLLQNNFQ-NVQILEAEDRIGGRI-NTVYFGDNVIDLGAQWCHGKQQNCV 72
            :||||||.:|:|||.:|  :||. .|.:|||:||||||: :...|....:..|||..:|...|.|
Human   394 VIIIGAGPAGLAAARQL--HNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRGAQIVNGCINNPV 456

  Fly    73 YDMVKDMGI-LHETGDYYSPIKRVRSNKEVVPHELACRIHDIAV-KSMPSGPHPVVGSFGTHL-T 134
            ..|.:.:|| :|:.|:....|:.            ..||.|..: |.|..       .|...| .
Human   457 ALMCEQLGISMHKFGERCDLIQE------------GGRITDPTIDKRMDF-------HFNALLDV 502

  Fly   135 QTFWRKIESELPQVN-RDVASEALNTFAK----------------HESSIIGA--DNLFEVSVR- 179
            .:.|||.:::|..|. .:...|....|.|                |.|::..|  .||.:||.|
Human   503 VSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHLSNLEYACGSNLHQVSARS 567

  Fly   180 -EHIEYH-ECDGDKLLHWGTKGYRRFLRLLMKVSADTPEELGLLEGRIQLDMKVIKIELAC---- 238
             :|.|:. :..||..|.  |.||...:.             .|.||   ||:::...::.|
Human   568 WDHNEFFAQFAGDHTLL--TPGYSVIIE-------------KLAEG---LDIQLKSPQVQCIDYS 614

  Fly   239 PRKVILRCQDGDYFEADHVICTVSLGVLQEQHEKLFVPPLPAAKVNAIRSLTLGTVNKLYLEYEK 303
            ..:|.:...||..:.|..|:.||.|.:||:...: |.|||...|:.||.||..|.:.|:.|::.
Human   615 GDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQ-FNPPLSEKKMKAINSLGAGIIEKIALQFP- 677

  Fly   304 QPLPDGWVGFFCFWLEEDLIELRKTEYFW-------VEGITGVHMITCQPR----MLMAWVNGPH 357
                      :.||..    :::..::|.       ..|:..| .....|:    :||:.:.|..
Human   678 ----------YRFWDS----KVQGADFFGHVPPSASKRGLFAV-FYDMDPQKKHSVLMSVIAGEA 727

  Fly   358 GRHMETLSDEKVLEGLYWLFRK-FLTFEIPPPKRFVRSSWFSNPNFRGSWSYRGVMADERNTGPW 421
            ...:.||.|::||:......|: |...|:|.|.::..:.|.::|..:.::|:       ..||..
Human   728 VASVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSF-------VKTGGS 785

  Fly   422 DLESPVLGEDGHLGLLFAGEASSRNHFSTVHGAVEAGYREADRL 465
            .....::.||....:.|||||::|:...||.||..:|.|||.::
Human   786 GEAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5653	NP_648269.1	Amino_oxidase	17..466	CDD:396255	129/492 (26%)
KDM1B	NP_001426046.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	282..301
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	447..476		8/28 (29%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	496..507		2/10 (20%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	547..581		11/33 (33%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	573..575		0/1 (0%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	808..824		6/15 (40%)