Protein Alignment ValRS-m and VAS1

DIOPT Version :10

• Sequence 1: NP_648268.1
• Gene: ValRS-m / 39023
• FlyBaseID: FBgn0035942
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_011608.1
• Gene: VAS1 / 852986
• SGDID: S000003326
• Length: 1104
• Species: Saccharomyces cerevisiae
• Alignment Length: 1018
• Identity: 362/1018 - (35%)
• Similarity: 545/1018 - (53%)
• Gaps: 123/1018 - (12%)

  Fly    38 PLAAGYQPQPVENAYWEREHRQANL-PKASASSCKR--GTYRMLLPPPNVTGNLHLGHALMATVQ 99
            |....|.|..||:::::...:.... |:.:|....:  |.:.:..|||||||.||:||||...:|
Yeast   143 PALKAYNPANVESSWYDWWIKTGVFEPEFTADGKVKPEGVFCIPAPPPNVTGALHIGHALTIAIQ 207

  Fly   100 DVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAEKGAG 164
            |.:.|.....|..|.::||.||||||||.|||:.|.|...||||:.||.||:.:||.||.|..:.
Yeast   208 DSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSR 272

  Fly   165 IVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVD 229
            |...:::||...:|.||.||:..:...:|..||.||.:||:|.|.:.:|||...|.:|||::||:
Yeast   273 IKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVE 337

  Fly   230 SVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRPETILGDVAVAVHP 294
            :.::.....:||||||.||.||.:..|||.|:       ||.|:::::|||||||.||.||||||
Yeast   338 NKDVKSRTLLSVPGYDEKVEFGVLTSFAYPVI-------GSDEKLIIATTRPETIFGDTAVAVHP 395

  Fly   295 LDPRYAKYRNIDQVKLKHPFRDDTIPLVFD-ITVDQEFGTGAVKITPAHDKFDFELATRHKLEPR 358
            .|.|   |:::....::|||....||::.| ..||.||||||||||||||:.|:....||.||..
Yeast   396 DDDR---YKHLHGKFIQHPFLPRKIPIITDKEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFI 457

  Fly   359 QVFTETGLV-VDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILP 422
            .:.|:.||: .:...|::|:.||:||..::.:|:|.:|......:.|.:|.||||.|:||.::.|
Yeast   458 NILTDDGLLNEECGPEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKP 522

  Fly   423 QWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAY------E 481
            ||::...::||||:..:..|::.|.|.:.|.|:..||.:.:||||||||||||:.|.|      |
Yeast   523 QWWVSQSEMAKDAIKVVRDGQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGE 587

  Fly   482 VIDSQGNSQWVAALDEKTARQKAMRLIGSEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YK 544
            ..|......|||....:.|.:||.....:.:|||::|.|||||||||.|.||||.||||::  .:
Yeast   588 EHDRIDGDYWVAGRSMEEAEKKAAAKYPNSKFTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDME 652

  Fly   545 ERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQV 609
            ..||..:::||.||:||||.||::|||||||..||:.:..:.:|.||.|||||||:||::.|..|
Yeast   653 TFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDV 717

  Fly   610 VQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTDALRFTLMSHNIKSHFIS 674
            :.|..|:.|.|.|.|    |.:.|.|::.:.||..:.:||||.:|||||:||.|.::......|:
Yeast   718 ITGIKLDDLHAKLLQ----GNLDPREVEKAKIGQKESYPNGIPQCGTDAMRFALCAYTTGGRDIN 778

  Fly   675 FDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETLEGV--NLGLWDRWIVGRLAETLSVC 737
            .|:......:.|.||::||.:|.|   ..||.. :|....||:  |..|.::||:.:|.||..:.
Yeast   779 LDILRVEGYRKFCNKIYQATKFAL---MRLGDD-YQPPATEGLSGNESLVEKWILHKLTETSKIV 839

  Fly   738 SQSYSNYNFHLATAALKTFFYQYLCDTYLETTK------PAIGNRSADAYIHVGTLTACLSWGLQ 796
            :::....:|..:|:::..|:| .:||.|:|.:|      .||..:||.     .||...|...|:
Yeast   840 NEALDKRDFLTSTSSIYEFWY-LICDVYIENSKYLIQEGSAIEKKSAK-----DTLYILLDNALK 898

  Fly   797 AMAPYAPFVASELLQHVP------------LNIELKLSDYKDEKLEEEVNEIVNICHNVRQVKSR 849
            .:.|:.||::.|:.|.:|            .:..:.:|:|.|.|.....:.::||....|.:.|.
Yeast   899 LIHPFMPFISEEMWQRLPKRSTEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSE 963

  Fly   850 NEISK--------RHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDV----------------- 889
            ..|.|        .|...........||...|.:.:.::.|:....::
Yeast   964 YNILKNGKVFVESNHEEYFKTAEDQKDSIVSLIKAIDEVTVVRDASEIPEGCVLQSVNPEVNVHL 1028

  Fly   890 ----ELELFDESSKISKQLSYFSTAGALCSFGLKLSDGLDLTPEKRDEMQKANAKKLKKLVTELQ 950
                .:::..|.:|:.|:|..          ..|..:|::.|...:|...|||.:
Yeast  1029 LVKGHVDIDAEIAKVQKKLEK----------AKKSKNGIEQTINSKDYETKANTQ---------- 1073

  Fly   951 RYRMRLDNEAFQLMADKKVKSHFENKVKE---LEAEINSLTRL 990
                          |.:..||..:|.|.|   |||.|.:|.||
Yeast  1074 --------------AKEANKSKLDNTVAEIEGLEATIENLKRL 1102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_648268.1	PTZ00419	23..989	CDD:240411	360/1015 (35%)
VAS1	NP_011608.1	PTZ00419	128..1104	CDD:240411	362/1018 (36%)